Egf epidermal growth factor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Egfprovided by MGI
Official Full Name: epidermal growth factorprovided by MGI
Primary source: MGI:MGI:95290
See related: Ensembl:ENSMUSG00000028017 AllianceGenome:MGI:95290
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: This gene encodes epidermal growth factor (EGF), the founding member of the EGF family of growth factors that are implicated in cell proliferation and differentiation. The encoded protein can localize to the membrane and function in juxtacrine signaling or undergo proteolytic processing to generate a soluble form of the hormone. Mice lacking the encoded protein do not exhibit an abnormal phenotype but transgenic mice overexpressing the encoded protein exhibit hypospermatogenesis. [provided by RefSeq, Jul 2016]
Expression: Restricted expression toward kidney adult (RPKM 187.5) See more
Orthologs: human all
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Genomic context

Location:: 3 G3; 3 58.5 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (129471223..129548971, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (129677574..129755322, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Potential therapeutic target of EGF on bile duct ligation model and biliary atresia children.
Title: Potential therapeutic target of EGF on bile duct ligation model and biliary atresia children.
Aerobic Treadmill Exercise Upregulates Epidermal Growth Factor Levels and Improves Learning and Memory in d-galactose-Induced Aging in a Mouse Model.
Title: Aerobic Treadmill Exercise Upregulates Epidermal Growth Factor Levels and Improves Learning and Memory in d-galactose-Induced Aging in a Mouse Model.
Epidermal growth factor deficiency predisposes to progressive renal disease.
Title: Epidermal growth factor deficiency predisposes to progressive renal disease.
Post-pubertal Difference in Nigral Dopaminergic Cells Firing in the Schizophrenia Model Prepared by Perinatal Challenges of a Cytokine, EGF.
Title: Post-pubertal Difference in Nigral Dopaminergic Cells Firing in the Schizophrenia Model Prepared by Perinatal Challenges of a Cytokine, EGF.
Epidermal growth factor regulation by autophagy-mediated lncRNA H19 in murine intestinal tract after severe burn.
Title: Epidermal growth factor regulation by autophagy-mediated lncRNA H19 in murine intestinal tract after severe burn.
Colorectal cancer cells promote osteoclastogenesis and bone destruction through regulating EGF/ERK/CCL3 pathway.
Title: Colorectal cancer cells promote osteoclastogenesis and bone destruction through regulating EGF/ERK/CCL3 pathway.
EGF-induced CREB activity by MAPK3/1 and Ca(2+) /CaMKII signaling pathways promotes the expansion-related gene expression and consequent cumulus expansion.
Title: CREB activity is required for epidermal growth factor-induced mouse cumulus expansion.
EGF activates ETS2 to inhibit miR-124a expression to maintain proper beta cell functions and ETS2, as a novel regulator of insulin production, is a potential therapeutic target for diabetes mellitus treatment.
Title: EGF suppresses the expression of miR-124a in pancreatic β cell lines via ETS2 activation through the MEK and PI3K signaling pathways.
VEGF accelerates compensatory lung growth in mice by increasing the alveolar units in a process medicated by VEGFR2 and EGF
Title: Vascular endothelial growth factor accelerates compensatory lung growth by increasing the alveolar units.
In mice, both EGF and pimecrolimus groups showed less erythema with significantly reduced inflammation and decreased expression of thymic stromal lymphopoietin. EGF relieved S. aureus-induced inflammation and AD-like skin lesions in Nc/Nga mice.
Title: Epidermal Growth Factor Relieves Inflammatory Signals in Staphylococcus aureus-Treated Human Epidermal Keratinocytes and Atopic Dermatitis-Like Skin Lesions in Nc/Nga Mice.

Submit: New GeneRIF Correction See all GeneRIFs (107)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI790464 (e-PCR)
- UniSTS:163332

Egf (e-PCR), detects polymorphism
- UniSTS:226080

Egf (e-PCR), detects polymorphism
- UniSTS:265571

Egf (e-PCR), detects polymorphism
- UniSTS:142972

J00380 (e-PCR)
- UniSTS:124849

Egf (e-PCR), detects polymorphism
- UniSTS:548061

Egf (e-PCR), detects polymorphism
- UniSTS:233968

Egf (e-PCR), detects polymorphism
- UniSTS:516080

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables epidermal growth factor receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables epidermal growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info	PubMed
enables transmembrane receptor protein tyrosine kinase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane receptor protein tyrosine kinase activator activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in ERBB2-EGFR signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in ERBB2-EGFR signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
involved_in ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within branching morphogenesis of an epithelial tube	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of cerebellar granule cell precursor proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within epidermal growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within epidermal growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of epithelial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within mammary gland alveolus development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cholesterol efflux	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA binding	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cerebellar granule cell precursor proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of epithelial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of epithelial tube formation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hyaluronan biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to early endosome	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of calcium ion import	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein localization to cell surface	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein transport	ISO Inferred from Sequence Orthology more info	PubMed
involved_in regulation of receptor signaling pathway via JAK-STAT	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: pro-epidermal growth factor

Names: Pro-epidermal growth factor precursor (EGF)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001310737.1 → NP_001297666.1 pro-epidermal growth factor isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start site compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.

Source sequence(s)

AC098732, AK136439, AK157778, BP761200

Consensus CDS

CCDS80020.1

UniProtKB/TrEMBL

A0A0G2JF92, Q3UWD7

Related

ENSMUSP00000143075.2, ENSMUST00000197079.5

Conserved Domains (5) summary

PHA02887
Location:481 → 518

PHA02887; EGF-like protein; Provisional

smart00135
Location:95 → 138

LY; Low-density lipoprotein-receptor YWTD domain

pfam07001
Location:609 → 700

BAT2_N; BAT2 N-terminus

pfam07645
Location:376 → 416

EGF_CA; Calcium-binding EGF domain

pfam14670
Location:250 → 285

FXa_inhibition; Coagulation Factor Xa inhibitory site
NM_001329594.1 → NP_001316523.1 pro-epidermal growth factor isoform 3

Status: REVIEWED

Source sequence(s)

AC098732, AK085707, BB635280, BP761200

Consensus CDS

CCDS89687.1

UniProtKB/TrEMBL

A0A0G2JDT8, Q3UWD7

Related

ENSMUSP00000142497.2, ENSMUST00000199615.5
NM_010113.4 → NP_034243.2 pro-epidermal growth factor isoform 1 preproprotein

See identical proteins and their annotated locations for NP_034243.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC098732, AK136439, BP761200

Consensus CDS

CCDS17833.1

UniProtKB/Swiss-Prot

E9QNX6, P01132, Q569W5, Q6P9J2

UniProtKB/TrEMBL

Q8VD07

Related

ENSMUSP00000029653.3, ENSMUST00000029653.7

Conserved Domains (5) summary

PHA02887
Location:982 → 1019

PHA02887; EGF-like protein; Provisional

smart00135
Location:596 → 639

LY; Low-density lipoprotein-receptor YWTD domain

pfam07645
Location:877 → 917

EGF_CA; Calcium-binding EGF domain

pfam14670
Location:449 → 482

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl00057
Location:358 → 399

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

129471223..129548971 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006500990.5 → XP_006501053.1 pro-epidermal growth factor isoform X3

UniProtKB/TrEMBL

Q8VD07

Conserved Domains (4) summary

PHA02887
Location:941 → 978

PHA02887; EGF-like protein; Provisional

smart00135
Location:596 → 639

LY; Low-density lipoprotein-receptor YWTD domain

pfam07645
Location:877 → 917

EGF_CA; Calcium-binding EGF domain

pfam14670
Location:366 → 401

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_011240011.4 → XP_011238313.1 pro-epidermal growth factor isoform X2

UniProtKB/TrEMBL

Q8VD07

Conserved Domains (4) summary

PHA02887
Location:945 → 982

PHA02887; EGF-like protein; Provisional

smart00135
Location:600 → 643

LY; Low-density lipoprotein-receptor YWTD domain

pfam07645
Location:881 → 921

EGF_CA; Calcium-binding EGF domain

pfam14670
Location:370 → 405

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_011240010.4 → XP_011238312.1 pro-epidermal growth factor isoform X1

UniProtKB/TrEMBL

Q8VD07

Conserved Domains (4) summary

PHA02887
Location:986 → 1023

PHA02887; EGF-like protein; Provisional

smart00135
Location:600 → 643

LY; Low-density lipoprotein-receptor YWTD domain

pfam07645
Location:881 → 921

EGF_CA; Calcium-binding EGF domain

pfam14670
Location:370 → 405

FXa_inhibition; Coagulation Factor Xa inhibitory site