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CLDN3 claudin 3 [ Homo sapiens (human) ]

Gene ID: 1365, updated on 4-Jan-2025

Summary

Official Symbol
CLDN3provided by HGNC
Official Full Name
claudin 3provided by HGNC
Primary source
HGNC:HGNC:2045
See related
Ensembl:ENSG00000165215 MIM:602910; AllianceGenome:HGNC:2045
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RVP1; HRVP1; C7orf1; CPE-R2; CPETR2
Summary
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See CLDN3 in Genome Data Viewer
Location:
7q11.23
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (73768997..73770270, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (74969874..74971147, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (73183327..73184600, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26129 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:73152931-73153588 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:73153589-73154245 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:73156848-73158047 Neighboring gene BICD family like 3, pseudogene Neighboring gene abhydrolase domain containing 11 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:73175993-73176570 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:73176571-73177148 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:73213712-73214352 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18267 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:73234209-73234787 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:73236582-73237781 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:73241685-73242332 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:73242333-73242980 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:73245012-73245714 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:73245715-73246417 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26130 Neighboring gene claudin 4 Neighboring gene methyltransferase like 27

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of claudin 3 (CLDN3) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The exposure to HIV-1 or HIV-1 gp120 results in a significant downregulation of tight junction proteins ZO-1, Occludin, Claudin-1, Claudin-2, Claudin-3, Claudin-4, and Claudin-5 in human retinal pigment epithelial cells PubMed
env The expression of tight junction proteins ZO-1, JAM-2, Occludin, Claudin-3 and Claudin-5 is modulated by HIV-1 gp120, and the modulated TJ expression involves Rho-A activation PubMed
Tat tat HIV-1 Tat disrupts and downregulates the tight-junction proteins claudin-1, claudin-3, and claudin-4 in retinal pigment epithelial cells, whereas claudin-2 is upregulated PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Items 1 - 25 of 26
Process Evidence Code Pubs
involved_in actin cytoskeleton organization PubMed 
involved_in bicellular tight junction assembly  
involved_in bicellular tight junction assembly PubMed 
involved_in calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules  
involved_in cell adhesion  
involved_in cell junction maintenance  
involved_in epithelial cell morphogenesis  
involved_in establishment of endothelial blood-brain barrier  
involved_in maintenance of blood-brain barrier PubMed 
involved_in negative regulation of cell migration PubMed 
involved_in negative regulation of cell population proliferation PubMed 
involved_in negative regulation of gene expression PubMed 
involved_in negative regulation of wound healing PubMed 
involved_in positive regulation of bicellular tight junction assembly PubMed 
involved_in positive regulation of cell junction assembly PubMed 
involved_in positive regulation of cell migration PubMed 
involved_in positive regulation of gene expression PubMed 
involved_in positive regulation of metallopeptidase activity PubMed 
involved_in positive regulation of protein phosphorylation PubMed 
involved_in positive regulation of wound healing PubMed 
involved_in regulation of cell morphogenesis PubMed 
involved_in regulation of membrane permeability PubMed 
involved_in regulation of transepithelial transport PubMed 
involved_in response to Gram-positive bacterium  
involved_in response to ethanol  
involved_in response to hypoxia PubMed 
Items 1 - 25 of 26
Component Evidence Code Pubs
located_in apical junction complex PubMed 
located_in apicolateral plasma membrane  
is_active_in bicellular tight junction  
located_in bicellular tight junction PubMed 
located_in bicellular tight junction  
located_in cell-cell junction PubMed 
located_in lateral plasma membrane  
located_in membrane PubMed 
is_active_in plasma membrane  
part_of protein-containing complex PubMed 
located_in tight junction PubMed 
located_in tight junction PubMed 

General protein information

Preferred Names
claudin-3
Names
CPE-R 2
CPE-receptor 2
Clostridium perfringens enterotoxin receptor 2
ventral prostate.1 protein homolog
ventral prostate.1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012023.1 RefSeqGene

    Range
    5001..6274
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001306.4NP_001297.1  claudin-3

    See identical proteins and their annotated locations for NP_001297.1

    Status: REVIEWED

    Source sequence(s)
    BC016056, BM764277
    Consensus CDS
    CCDS5559.1
    UniProtKB/Swiss-Prot
    O15551
    UniProtKB/TrEMBL
    Q75L79
    Related
    ENSP00000378577.2, ENST00000395145.3
    Conserved Domains (1) summary
    cl21598
    Location:3167
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    73768997..73770270 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    74969874..74971147 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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