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CREM cAMP responsive element modulator [ Homo sapiens (human) ]

Gene ID: 1390, updated on 22-Apr-2024

Summary

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Official Symbol
CREMprovided by HGNC
Official Full Name
cAMP responsive element modulatorprovided by HGNC
Primary source
HGNC:HGNC:2352
See related
Ensembl:ENSG00000095794 MIM:123812; AllianceGenome:HGNC:2352
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ICER; CREM-2; hCREM-2
Summary
This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 19.2), adrenal (RPKM 15.7) and 21 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
10p11.21
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (35126846..35212958)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (35155414..35241554)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (35415774..35501886)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902409 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:35301624-35302194 Neighboring gene cullin 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2297 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2298 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:35379443-35379631 Neighboring gene microRNA 3611 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2299 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2300 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3259 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2301 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3261 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3262 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3263 Neighboring gene RNA, U7 small nuclear 77 pseudogene Neighboring gene ATPase H+ transporting V1 subunit G1 pseudogene 4 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:35500215-35500774 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:35503415-35503916 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2302 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:35517588-35518088 Neighboring gene long intergenic non-protein coding RNA 2634 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:35536556-35536734 Neighboring gene RNA, U6 small nuclear 794, pseudogene Neighboring gene RNA, U6 small nuclear 1167, pseudogene Neighboring gene cyclin Y

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Differential Expression of CREM/ICER Isoforms Is Associated with the Spontaneous Control of HIV Infection. Luo Z, et al. mBio, 2022 Feb 22. PMID 35041523, Free PMC Article
  2. Expression of Transcription Factor CREM in Human Tissues. Kaprio H, et al. J Histochem Cytochem, 2021 Aug. PMID 34261344, Free PMC Article
  3. The transcription factor CREM drives an inflammatory phenotype of T cells in oligoarticular juvenile idiopathic arthritis. Ohl K, et al. Pediatr Rheumatol Online J, 2018 Jun 20. PMID 29925386, Free PMC Article
  4. CREM variant rs17583959 conferred susceptibility to T1D risk in the Tunisian families. Zouidi F, et al. Immunol Lett, 2017 Jan. PMID 27840176
  5. Constitutive Expression of Inducible Cyclic Adenosine Monophosphate Early Repressor (ICER) in Cycling Quiescent Hematopoietic Cells: Implications for Aging Hematopoietic Stem Cells. Greco SJ, et al. Stem Cell Rev Rep, 2017 Feb. PMID 27822872

See all (141) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cardiac-specific overexpression of CREM-IbDeltaC-X via CRISPR/Cas9 in mice presents a new model of atrial cardiomyopathy with spontaneous atrial fibrillation.
    Title: Cardiac-specific overexpression of CREM-IbΔC-X via CRISPR/Cas9 in mice presents a new model of atrial cardiomyopathy with spontaneous atrial fibrillation.
  2. Novel Aspects of cAMP-Response Element Modulator (CREM) Role in Spermatogenesis and Male Fertility.
    Title: Novel Aspects of cAMP-Response Element Modulator (CREM) Role in Spermatogenesis and Male Fertility.
  3. Differential Expression of CREM/ICER Isoforms Is Associated with the Spontaneous Control of HIV Infection.
    Title: Differential Expression of CREM/ICER Isoforms Is Associated with the Spontaneous Control of HIV Infection.
  4. Decreased SUV39H1 at the promoter region leads to increased CREMalpha and accelerates autoimmune response in CD4[+] T cells from patients with systemic lupus erythematosus.
    Title: Decreased SUV39H1 at the promoter region leads to increased CREMα and accelerates autoimmune response in CD4(+) T cells from patients with systemic lupus erythematosus.
  5. Determining the expression levels of CSF-1 and OCT4, CREM-1, and protamine in testicular biopsies of adult Klinefelter patients: Their possible correlation with spermatogenesis.
    Title: Determining the expression levels of CSF-1 and OCT4, CREM-1, and protamine in testicular biopsies of adult Klinefelter patients: Their possible correlation with spermatogenesis.
  6. Evidence that the transcriptional repressor ICER is regulated via the N-end rule for ubiquitination.
    Title: Evidence that the transcriptional repressor ICER is regulated via the N-end rule for ubiquitination.
  7. Cytokeratin-positive Malignant Tumor in the Abdomen With EWSR1/FUS-CREB Fusion: A Clinicopathologic Study of 8 Cases.
    Title: Cytokeratin-positive Malignant Tumor in the Abdomen With EWSR1/FUS-CREB Fusion: A Clinicopathologic Study of 8 Cases.
  8. Expression of Transcription Factor CREM in Human Tissues.
    Title: Expression of Transcription Factor CREM in Human Tissues.
  9. Report the phenotypic spectrum of mesenchymal tumors associated with the EWSR1-CREM fusion.
    Title: Expanding the Phenotypic Spectrum of Mesenchymal Tumors Harboring the EWSR1-CREM Fusion.
  10. We describe a novel gene fusion, EWSR1-CREM, identified in 3 cases of clear cell carcinoma
    Title: Molecular Profiling of Hyalinizing Clear Cell Carcinomas Revealed a Subset of Tumors Harboring a Novel EWSR1-CREM Fusion: Report of 3 Cases.
Submit: New GeneRIF Correction See all GeneRIFs (81)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
EBI GWAS Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat Treatment of dopaminergic rat PC12 cells with HIV-1 Tat downregulates the expression of tyrosine hydroxylase (TH) by upregulating the expression of the inducible cAMP early repressor which in turn abrogates the transcription activity of the TH promoter PubMed
tat Extracellular HIV-1 Tat protein activates the inducible cAMP early repressor (ICER) in both the Jurkat cell line and primary peripheral blood mononuclear cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC17881, MGC41893, MGC111110

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cAMP response element binding protein binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in glycosphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rhythmic process IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of ATF4-CREB1 transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
cAMP-responsive element modulator
Names
CREM 2alpha-b protein
CREM 2beta-a protein
cAMP response element modulator
inducible cAMP early repressor ICER

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029065.1 RefSeqGene

    Range
    4974..91081
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001267562.2 → NP_001254491.1  cAMP-responsive element modulator isoform 23

    Status: REVIEWED

    Description
    Transcript Variant: This variant (23) has an alternate first exon, lacks the exon containing the translation start codon, and uses an alternate splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (23) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL117336, AY292864, BC041810, BG573680, BI459432
    UniProtKB/Swiss-Prot
    Q03060
    Conserved Domains (1) summary
    cd14690
    Location:122 → 176
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  2. NM_001267563.2 → NP_001254492.1  cAMP-responsive element modulator isoform 24

    See identical proteins and their annotated locations for NP_001254492.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (24) has an alternate first exon and lacks three other exons compared to variant 1. The resulting isoform (24) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AL117336, AL157783, BC041810, CB996061
    Conserved Domains (1) summary
    cd14690
    Location:59 → 113
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  3. NM_001267564.2 → NP_001254493.1  cAMP-responsive element modulator isoform 25

    Status: REVIEWED

    Description
    Transcript Variant: This variant (25) uses an alternate first exon in place of the first three exons and contains an alternate in-frame exon compared to variant 1. The resulting isoform (25) has a shorter and distinct N-terminus and contains an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AL117336, AY292864, BC041810, BU193626, CD358637
    Consensus CDS
    CCDS58074.1
    UniProtKB/Swiss-Prot
    Q03060
    Related
    ENSP00000379225.3, ENST00000395887.8
    Conserved Domains (1) summary
    cd14690
    Location:225 → 279
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  4. NM_001267565.2 → NP_001254494.1  cAMP-responsive element modulator isoform 26

    Status: REVIEWED

    Description
    Transcript Variant: This variant (26) lacks several exons and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. The resulting isoform (26) has distinct N- and C-termini compared to isoform 1.
    Source sequence(s)
    BU193626, BU570307, CK300763
    Conserved Domains (2) summary
    pfam02173
    Location:66 → 83
    pKID; pKID domain
    pfam13900
    Location:32 → 67
    GVQW; Putative domain of unknown function

  5. NM_001267566.2 → NP_001254495.1  cAMP-responsive element modulator isoform 27

    Status: REVIEWED

    Description
    Transcript Variant: This variant (27) lacks several exons and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. The resulting isoform (27) has distinct N- and C-termini compared to isoform 1.
    Source sequence(s)
    BP370901, BU570307, CK300763
    Conserved Domains (1) summary
    pfam02173
    Location:13 → 50
    pKID; pKID domain

  6. NM_001267567.2 → NP_001254496.1  cAMP-responsive element modulator isoform 28

    Status: REVIEWED

    Description
    Transcript Variant: This variant (28) has an alternate first exon in place of the first five exons compared to variant 1. The resulting isoform (28) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL117336, BC041810, BG720999
    Consensus CDS
    CCDS58075.1
    UniProtKB/Swiss-Prot
    Q03060
    Related
    ENSP00000418336.1, ENST00000463314.5
    Conserved Domains (1) summary
    cd14690
    Location:81 → 135
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  7. NM_001267568.2 → NP_001254497.1  cAMP-responsive element modulator isoform 29

    Status: REVIEWED

    Description
    Transcript Variant: This variant (29) has an alternate exon in place of the first six exons and has an alternate last exon compared to variant 1. The resulting isoform (29) has shorter and distinct N- and C-termini compared to isoform 1.
    Source sequence(s)
    AL117336, AW439476, CD639591, CD640977

  8. NM_001267569.2 → NP_001254498.1  cAMP-responsive element modulator isoform 30

    Status: REVIEWED

    Description
    Transcript Variant: This variant (30) has two alternate exons in place of the first six exons and has an alternate last exon compared to variant 1. The resulting isoform (30) has shorter and distinct N- and C-termini compared to isoform 1.
    Source sequence(s)
    AL117336, AW439476, CD640977

  9. NM_001267570.2 → NP_001254499.1  cAMP-responsive element modulator isoform 31

    Status: REVIEWED

    Description
    Transcript Variant: This variant (31) has two alternate exons in place of the first six exons compared to variant 1. The resulting isoform (31) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK289379, AL117336, BC041810, CD640465
    Consensus CDS
    CCDS58076.1
    UniProtKB/Swiss-Prot
    Q03060
    Related
    ENSP00000419810.1, ENST00000468236.5
    Conserved Domains (1) summary
    cd14690
    Location:68 → 122
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  10. NM_001352445.1 → NP_001339374.1  cAMP-responsive element modulator isoform 32

    Status: REVIEWED

    Source sequence(s)
    AK289379, AL117336, AL157783, BC041810, DA823429, HY169431
    Consensus CDS
    CCDS53522.1
    UniProtKB/TrEMBL
    E9PAR2
    Related
    ENSP00000344365.5, ENST00000344351.5
    Conserved Domains (1) summary
    cd14690
    Location:39 → 93
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  11. NM_001352446.1 → NP_001339375.1  cAMP-responsive element modulator isoform 33

    Status: REVIEWED

    Source sequence(s)
    AL117336, AL157783, BC041810, CD686814, D79104, DA823429, DT220562
    Consensus CDS
    CCDS53523.1
    UniProtKB/TrEMBL
    E9PB41
    Conserved Domains (1) summary
    cd14690
    Location:39 → 93
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  12. NM_001352465.2 → NP_001339394.1  cAMP-responsive element modulator isoform 33

    Status: REVIEWED

    Source sequence(s)
    AA453346, AL117336, AL157783, BC041810
    Consensus CDS
    CCDS53523.1
    UniProtKB/TrEMBL
    E9PB41
    Related
    ENSP00000419018.1, ENST00000474362.5
    Conserved Domains (1) summary
    cd14690
    Location:39 → 93
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  13. NM_001352466.2 → NP_001339395.1  cAMP-responsive element modulator isoform 32

    Status: REVIEWED

    Source sequence(s)
    AL117336, BC041810, CN367927
    Consensus CDS
    CCDS53522.1
    UniProtKB/TrEMBL
    E9PAR2
    Related
    ENSP00000420437.1, ENST00000460270.5
    Conserved Domains (1) summary
    cd14690
    Location:39 → 93
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  14. NM_001352467.2 → NP_001339396.1  cAMP-responsive element modulator isoform 32

    Status: REVIEWED

    Source sequence(s)
    AL117336, BC041810, DR760671
    Consensus CDS
    CCDS53522.1
    UniProtKB/TrEMBL
    E9PAR2
    Conserved Domains (1) summary
    cd14690
    Location:39 → 93
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  15. NM_001394595.1 → NP_001381524.1  cAMP-responsive element modulator isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL117336, AL157783
    Consensus CDS
    CCDS7180.1
    UniProtKB/Swiss-Prot
    A8K014, A8K3J7, A8K6A1, A8MPQ2, B4DXC1, C9J785, C9JZ10, E9PAR4, E9PHM1, O75519, Q03060, Q14501, Q14503, Q14504, Q14505, Q14506, Q15731, Q16114, Q16116, Q5T9H7, Q5W1A6, Q5W1A7, Q5W1A8, Q5W1A9, Q5W1B0
    Related
    ENSP00000510546.1, ENST00000686585.1
    Conserved Domains (2) summary
    cd14690
    Location:243 → 297
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:69 → 105
    pKID; pKID domain

  16. NM_001394598.1 → NP_001381527.1  cAMP-responsive element modulator isoform 34

    Status: REVIEWED

    Source sequence(s)
    AL117336, AL157783
    UniProtKB/Swiss-Prot
    A8K014, A8K3J7, A8K6A1, A8MPQ2, B4DXC1, C9J785, C9JZ10, E9PAR4, E9PHM1, O75519, Q03060, Q14501, Q14503, Q14504, Q14505, Q14506, Q15731, Q16114, Q16116, Q5T9H7, Q5W1A6, Q5W1A7, Q5W1A8, Q5W1A9, Q5W1B0
    Conserved Domains (2) summary
    cd14690
    Location:239 → 293
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:53 → 89
    pKID; pKID domain

  17. NM_001394600.1 → NP_001381529.1  cAMP-responsive element modulator isoform 35

    Status: REVIEWED

    Source sequence(s)
    AL117336, AL157783
    UniProtKB/Swiss-Prot
    A8K014, A8K3J7, A8K6A1, A8MPQ2, B4DXC1, C9J785, C9JZ10, E9PAR4, E9PHM1, O75519, Q03060, Q14501, Q14503, Q14504, Q14505, Q14506, Q15731, Q16114, Q16116, Q5T9H7, Q5W1A6, Q5W1A7, Q5W1A8, Q5W1A9, Q5W1B0
    Conserved Domains (2) summary
    cd14690
    Location:227 → 281
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:53 → 89
    pKID; pKID domain

  18. NM_001394602.1 → NP_001381531.1  cAMP-responsive element modulator isoform 36

    Status: REVIEWED

    Source sequence(s)
    AL117336, AL157783
    UniProtKB/Swiss-Prot
    A8K014, A8K3J7, A8K6A1, A8MPQ2, B4DXC1, C9J785, C9JZ10, E9PAR4, E9PHM1, O75519, Q03060, Q14501, Q14503, Q14504, Q14505, Q14506, Q15731, Q16114, Q16116, Q5T9H7, Q5W1A6, Q5W1A7, Q5W1A8, Q5W1A9, Q5W1B0
    Conserved Domains (2) summary
    cd14690
    Location:227 → 281
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:53 → 89
    pKID; pKID domain

  19. NM_001394603.1 → NP_001381532.1  cAMP-responsive element modulator isoform 37

    Status: REVIEWED

    Source sequence(s)
    AL117336, AL157783
    Conserved Domains (1) summary
    pfam02173
    Location:53 → 89
    pKID; pKID domain

  20. NM_001394605.1 → NP_001381534.1  cAMP-responsive element modulator isoform 38

    Status: REVIEWED

    Source sequence(s)
    AL117336, AL157783
    Conserved Domains (2) summary
    cd14690
    Location:188 → 242
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:14 → 50
    pKID; pKID domain

  21. NM_001394608.1 → NP_001381537.1  cAMP-responsive element modulator isoform 39

    Status: REVIEWED

    Source sequence(s)
    AL117336, AL157783
    Related
    ENSP00000419684.2, ENST00000463960.5
    Conserved Domains (2) summary
    cd14690
    Location:176 → 230
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:53 → 89
    pKID; pKID domain

  22. NM_001394610.1 → NP_001381539.1  cAMP-responsive element modulator isoform 40

    Status: REVIEWED

    Source sequence(s)
    AL117336, AL157783
    UniProtKB/TrEMBL
    G5E998
    Conserved Domains (2) summary
    cd14690
    Location:176 → 230
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:53 → 89
    pKID; pKID domain

  23. NM_001394613.1 → NP_001381542.1  cAMP-responsive element modulator isoform 22

    Status: REVIEWED

    Source sequence(s)
    AL117336, AL157783
    Consensus CDS
    CCDS7183.1
    UniProtKB/TrEMBL
    G5E998
    Conserved Domains (2) summary
    cd14690
    Location:164 → 218
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:53 → 89
    pKID; pKID domain

  24. NM_001394614.1 → NP_001381543.1  cAMP-responsive element modulator isoform 42

    Status: REVIEWED

    Source sequence(s)
    AL117336, AL157783
    UniProtKB/TrEMBL
    C9IYM9
    Conserved Domains (2) summary
    cd14690
    Location:164 → 218
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:53 → 89
    pKID; pKID domain

  25. NM_001394615.1 → NP_001381544.1  cAMP-responsive element modulator isoform 43

    Status: REVIEWED

    Source sequence(s)
    AL117336, AL157783
    Conserved Domains (1) summary
    cd14690
    Location:134 → 188
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  26. NM_001394616.1 → NP_001381545.1  cAMP-responsive element modulator isoform 44

    Status: REVIEWED

    Source sequence(s)
    AL117336, AL157783
    UniProtKB/TrEMBL
    C9IYM9
    Conserved Domains (1) summary
    pfam02173
    Location:53 → 89
    pKID; pKID domain

  27. NM_001394617.1 → NP_001381546.1  cAMP-responsive element modulator isoform 23

    Status: REVIEWED

    Source sequence(s)
    AL117336, AL157783
    Conserved Domains (1) summary
    cd14690
    Location:122 → 176
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  28. NM_001394618.1 → NP_001381547.1  cAMP-responsive element modulator isoform 46

    Status: REVIEWED

    Source sequence(s)
    AL117336, AL157783
    UniProtKB/TrEMBL
    Q59FC7
    Conserved Domains (1) summary
    cd14690
    Location:122 → 176
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  29. NM_001394619.1 → NP_001381548.1  cAMP-responsive element modulator isoform 46

    Status: REVIEWED

    Source sequence(s)
    AL117336, AL157783
    UniProtKB/TrEMBL
    Q59FC7
    Conserved Domains (1) summary
    cd14690
    Location:122 → 176
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  30. NM_001394620.1 → NP_001381549.1  cAMP-responsive element modulator isoform 47

    Status: REVIEWED

    Source sequence(s)
    AL157783
    UniProtKB/TrEMBL
    A0A0A0MSU8
    Conserved Domains (1) summary
    pfam02173
    Location:69 → 105
    pKID; pKID domain

  31. NM_001394621.1 → NP_001381550.1  cAMP-responsive element modulator isoform 53

    Status: REVIEWED

    Source sequence(s)
    AL117336, AL157783
    UniProtKB/TrEMBL
    Q59FC7
    Conserved Domains (1) summary
    cd14690
    Location:93 → 147
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  32. NM_001394622.1 → NP_001381551.1  cAMP-responsive element modulator isoform 48

    Status: REVIEWED

    Source sequence(s)
    AL117336, AL157783

  33. NM_001394623.1 → NP_001381552.1  cAMP-responsive element modulator isoform 45

    Status: REVIEWED

    Source sequence(s)
    AL117336, AL157783
    UniProtKB/TrEMBL
    Q59FC7
    Conserved Domains (1) summary
    cd14690
    Location:81 → 135
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  34. NM_001394625.1 → NP_001381554.1  cAMP-responsive element modulator isoform 49

    Status: REVIEWED

    Source sequence(s)
    AL117336, AL157783
    Conserved Domains (1) summary
    cd14690
    Location:71 → 125
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  35. NM_001394626.1 → NP_001381555.1  cAMP-responsive element modulator isoform 50

    Status: REVIEWED

    Source sequence(s)
    AL117336, AL157783
    Conserved Domains (1) summary
    cd14690
    Location:71 → 125
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  36. NM_001394627.1 → NP_001381556.1  cAMP-responsive element modulator isoform 50

    Status: REVIEWED

    Source sequence(s)
    AL117336, AL157783
    Conserved Domains (1) summary
    cd14690
    Location:71 → 125
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  37. NM_001394628.1 → NP_001381557.1  cAMP-responsive element modulator isoform 51

    Status: REVIEWED

    Source sequence(s)
    AL117336, AL157783
    Conserved Domains (1) summary
    cd14690
    Location:59 → 113
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  38. NM_001394629.1 → NP_001381558.1  cAMP-responsive element modulator isoform 51

    Status: REVIEWED

    Source sequence(s)
    AL117336, AL157783
    Conserved Domains (1) summary
    cd14690
    Location:59 → 113
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  39. NM_001394630.1 → NP_001381559.1  cAMP-responsive element modulator isoform 52

    Status: REVIEWED

    Source sequence(s)
    AL117336, AL157783

  40. NM_001394631.1 → NP_001381560.1  cAMP-responsive element modulator isoform 54

    Status: REVIEWED

    Source sequence(s)
    AL157783

  41. NM_001881.4 → NP_001872.3  cAMP-responsive element modulator isoform 2

    See identical proteins and their annotated locations for NP_001872.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. These differences cause translation initiation at a downstream ATG, and result in a shorter isoform (2, also known as b) with a shorter N-terminus and a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC017117, BC066342
    Consensus CDS
    CCDS7184.1
    UniProtKB/Swiss-Prot
    Q03060
    Related
    ENSP00000363858.3, ENST00000374726.7
    Conserved Domains (1) summary
    pfam02173
    Location:52 → 89
    pKID; pKID domain

  42. NM_181571.3 → NP_853549.1  cAMP-responsive element modulator isoform 1

    See identical proteins and their annotated locations for NP_853549.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). This isoform represents an activator tau2 isoform.
    Source sequence(s)
    AL117336, AL157783, BC041810, BI561543
    Consensus CDS
    CCDS7180.1
    UniProtKB/Swiss-Prot
    A8K014, A8K3J7, A8K6A1, A8MPQ2, B4DXC1, C9J785, C9JZ10, E9PAR4, E9PHM1, O75519, Q03060, Q14501, Q14503, Q14504, Q14505, Q14506, Q15731, Q16114, Q16116, Q5T9H7, Q5W1A6, Q5W1A7, Q5W1A8, Q5W1A9, Q5W1B0
    Related
    ENSP00000265372.5, ENST00000345491.7
    Conserved Domains (2) summary
    cd14690
    Location:243 → 297
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:69 → 105
    pKID; pKID domain

  43. NM_182717.2 → NP_874386.1  cAMP-responsive element modulator isoform 4

    See identical proteins and their annotated locations for NP_874386.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), also known as ICER1 and hCREM 2alpha-a, uses an alternative downstream promoter, and differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (4, also known as d) with distinct N- and C-termini, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
    Source sequence(s)
    AL117336, AL157783, BC041810, D14825, D14826
    Consensus CDS
    CCDS7187.1
    UniProtKB/Swiss-Prot
    Q03060
    Related
    ENSP00000420681.1, ENST00000473940.5
    Conserved Domains (1) summary
    cd14690
    Location:64 → 118
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  44. NM_182718.2 → NP_874387.1  cAMP-responsive element modulator isoform 5

    See identical proteins and their annotated locations for NP_874387.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), also known as ICER11 gamma and hCREM 2beta-b, uses an alternative downstream promoter, and differs in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter isoform (5, also known as e) with a distinct N-terminus, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
    Source sequence(s)
    AL117336, BC041810, CN367927, D14826
    Consensus CDS
    CCDS53519.1
    UniProtKB/Swiss-Prot
    Q03060
    Related
    ENSP00000417460.1, ENST00000488328.5
    Conserved Domains (1) summary
    cd14690
    Location:52 → 106
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  45. NM_182719.2 → NP_874388.1  cAMP-responsive element modulator isoform 6

    See identical proteins and their annotated locations for NP_874388.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), also known as ICER11 and hCREM 2beta-a, uses an alternative downstream promoter, and differs in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter isoform (6, also known as f) with a distinct N-terminus, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
    Source sequence(s)
    AL117336, AL157783, BC041810, D14825, D14826
    Consensus CDS
    CCDS53517.1
    UniProtKB/Swiss-Prot
    Q03060
    Related
    ENSP00000417807.1, ENST00000487763.5
    Conserved Domains (1) summary
    cd14690
    Location:64 → 118
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  46. NM_182720.2 → NP_874389.1  cAMP-responsive element modulator isoform 7

    See identical proteins and their annotated locations for NP_874389.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), also known as ICER1 gamma and hCREM 2alpha-b, uses an alternative downstream promoter, and differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (7, also known as g) with distinct N- and C-termini, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
    Source sequence(s)
    AL117336, BC041810, CN367927, D14826
    Consensus CDS
    CCDS53518.1
    UniProtKB/Swiss-Prot
    Q03060
    Related
    ENSP00000349387.5, ENST00000356917.9
    Conserved Domains (1) summary
    cd14690
    Location:52 → 106
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  47. NM_182721.2 → NP_874390.1  cAMP-responsive element modulator isoform 8

    See identical proteins and their annotated locations for NP_874390.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) uses an alternative downstream promoter, and differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (8, also known as h) with distinct N- and C-termini, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
    Source sequence(s)
    AK289379, AL117336, BC041810
    Consensus CDS
    CCDS7188.1
    UniProtKB/Swiss-Prot
    Q03060
    Related
    ENSP00000417562.1, ENST00000474931.5
    Conserved Domains (1) summary
    cd14690
    Location:56 → 110
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  48. NM_182723.2 → NP_874392.1  cAMP-responsive element modulator isoform 10

    See identical proteins and their annotated locations for NP_874392.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) uses an alternative downstream promoter, and differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (10, also known as j) with distinct N- and C-termini, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
    Source sequence(s)
    AL117336, BC041810, CD686814
    Consensus CDS
    CCDS53521.1
    UniProtKB/Swiss-Prot
    Q03060
    Related
    ENSP00000419075.1, ENST00000488741.5
    Conserved Domains (1) summary
    cd14690
    Location:46 → 100
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  49. NM_182724.2 → NP_874393.1  cAMP-responsive element modulator isoform 11

    See identical proteins and their annotated locations for NP_874393.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) uses an alternative downstream promoter, and differs in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter isoform (11, also known as k) with a distinct N-terminus, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
    Source sequence(s)
    AK289379, AL117336, BC041810
    Consensus CDS
    CCDS53520.1
    UniProtKB/Swiss-Prot
    Q03060
    Related
    ENSP00000417327.1, ENST00000490511.1
    Conserved Domains (1) summary
    cd14690
    Location:56 → 110
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  50. NM_182769.3 → NP_877570.1  cAMP-responsive element modulator isoform 13

    See identical proteins and their annotated locations for NP_877570.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), also known as CREM theta2-tau2-beta, uses an alternative downstream promoter, and differs in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter isoform (13, also known as m) with a distinct N-terminus, compared to isoform 1. This isoform represents an activator isoform theta 2.
    Source sequence(s)
    AL117336, AY292864, BC041810, BG719264, BP370901
    Consensus CDS
    CCDS7186.1
    UniProtKB/Swiss-Prot
    Q03060
    Related
    ENSP00000341875.3, ENST00000342105.7
    Conserved Domains (2) summary
    cd14690
    Location:188 → 242
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:13 → 50
    pKID; pKID domain

  51. NM_182770.3 → NP_877571.1  cAMP-responsive element modulator isoform 14

    See identical proteins and their annotated locations for NP_877571.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), also known as CREM theta2-beta, uses an alternative downstream promoter, differs in the 5' UTR and has multiple coding region differences, compared to variant 1. This results in a shorter isoform (14, also known as n) with a distinct N-terminus, compared to isoform 1. This isoform represents a repressor isoform theta 2.
    Source sequence(s)
    AL117336, AY292864, BC041810, BG719264, BP370901
    UniProtKB/TrEMBL
    C9K092
    Conserved Domains (2) summary
    cd14690
    Location:125 → 179
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:13 → 50
    pKID; pKID domain

  52. NM_182771.2 → NP_877572.1  cAMP-responsive element modulator isoform 15

    See identical proteins and their annotated locations for NP_877572.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), also known as CREM theta1-tau2-beta, uses an alternative downstream promoter, and differs in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter isoform (15, also known as o) with a distinct N-terminus, compared to isoform 1. This isoform represents an activator isoform theta 1.
    Source sequence(s)
    AL117336, AY292864, BC041810, BG719264
    Consensus CDS
    CCDS7185.1
    UniProtKB/Swiss-Prot
    Q03060
    Related
    ENSP00000354593.4, ENST00000361599.8
    Conserved Domains (2) summary
    cd14690
    Location:213 → 267
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:38 → 75
    pKID; pKID domain

  53. NM_182772.2 → NP_877573.1  cAMP-responsive element modulator isoform 16

    See identical proteins and their annotated locations for NP_877573.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), also known as CREM theta1-beta, uses an alternative downstream promoter, differs in the 5' UTR and has multiple coding region differences, compared to variant 1. This results in a shorter isoform (16, also known as p) with a distinct N-terminus, compared to isoform 1. This isoform represents a repressor isoform theta 1.
    Source sequence(s)
    AL117336, AY292864, BC041810, BG719264
    UniProtKB/TrEMBL
    J3KR46
    Related
    ENSP00000417165.1, ENST00000484283.5
    Conserved Domains (2) summary
    cd14690
    Location:150 → 204
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:38 → 75
    pKID; pKID domain

  54. NM_183011.2 → NP_898829.1  cAMP-responsive element modulator isoform 21

    See identical proteins and their annotated locations for NP_898829.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21), also known as CREM 10, differs in the 5' UTR, 3' UTR, and contains an additional segment in the coding region, compared to variant 1. This results in a shorter isoform (21, also known as u) with a distinct C-terminus, compared to isoform 1. This isoform represents the tau2 activator isoform.
    Source sequence(s)
    AL117336, AL157783
    Consensus CDS
    CCDS7181.1
    UniProtKB/Swiss-Prot
    A8K014, A8K3J7, A8K6A1, A8MPQ2, B4DXC1, C9J785, C9JZ10, E9PAR4, E9PHM1, O75519, Q03060, Q14501, Q14503, Q14504, Q14505, Q14506, Q15731, Q16114, Q16116, Q5T9H7, Q5W1A6, Q5W1A7, Q5W1A8, Q5W1A9, Q5W1B0
    Related
    ENSP00000509489.1, ENST00000685392.1
    Conserved Domains (2) summary
    cd14690
    Location:243 → 297
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:68 → 105
    pKID; pKID domain

  55. NM_183012.2 → NP_898830.1  cAMP-responsive element modulator isoform 20

    See identical proteins and their annotated locations for NP_898830.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20), also known as CREM 22, differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (20, also known as t) with a distinct C-terminus, compared to isoform 1. This isoform represents the type alpha repressor isoform.
    Source sequence(s)
    AL117336, AL157783
    Consensus CDS
    CCDS31181.1
    UniProtKB/TrEMBL
    G5E998
    Related
    ENSP00000363866.3, ENST00000374734.7
    Conserved Domains (2) summary
    cd14690
    Location:180 → 234
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:68 → 105
    pKID; pKID domain

  56. NM_183013.3 → NP_898831.1  cAMP-responsive element modulator isoform 19

    See identical proteins and their annotated locations for NP_898831.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19), also known as hCREM type1 alpha, differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (19, also known as s) with a distinct C-terminus, compared to isoform 1. This isoform represents the type alpha repressor isoform.
    Source sequence(s)
    AL117336, AL157783, BC041810, D14825, DA756152
    Consensus CDS
    CCDS7182.1
    UniProtKB/TrEMBL
    G5E998
    Related
    ENSP00000346804.3, ENST00000354759.7
    Conserved Domains (2) summary
    cd14690
    Location:192 → 246
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:68 → 105
    pKID; pKID domain

  57. NM_183060.3 → NP_898883.1  cAMP-responsive element modulator isoform 22

    See identical proteins and their annotated locations for NP_898883.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22) differs in the 5' UTR and lacks an in-frame segment of the coding region, compared to variant 1. This variant uses a downstream start codon, compared to variant 1. The resulting isoform (22, also known as v) is shorter and has a shorter N-terminus, compared to isoform 1. This isoform represents the type alpha repressor isoform.
    Source sequence(s)
    AL117336, AL157783, AV707433, BC041810, BI561543
    Consensus CDS
    CCDS7183.1
    UniProtKB/TrEMBL
    G5E998
    Related
    ENSP00000418798.2, ENST00000487132.6
    Conserved Domains (2) summary
    cd14690
    Location:164 → 218
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:53 → 89
    pKID; pKID domain

RNA

  1. NR_172138.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL157783

  2. NR_172139.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL117336, AL157783

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    35126846..35212958
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447824.2 → XP_024303592.1  cAMP-responsive element modulator isoform X2

    UniProtKB/Swiss-Prot
    A8K014, A8K3J7, A8K6A1, A8MPQ2, B4DXC1, C9J785, C9JZ10, E9PAR4, E9PHM1, O75519, Q03060, Q14501, Q14503, Q14504, Q14505, Q14506, Q15731, Q16114, Q16116, Q5T9H7, Q5W1A6, Q5W1A7, Q5W1A8, Q5W1A9, Q5W1B0
    Conserved Domains (2) summary
    cd14690
    Location:304 → 358
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:117 → 154
    pKID; pKID domain

  2. XM_047424625.1 → XP_047280581.1  cAMP-responsive element modulator isoform X1

    Related
    ENSP00000393538.2, ENST00000429130.7

  3. XM_047424628.1 → XP_047280584.1  cAMP-responsive element modulator isoform X4

  4. XM_047424627.1 → XP_047280583.1  cAMP-responsive element modulator isoform X3

  5. XM_047424630.1 → XP_047280586.1  cAMP-responsive element modulator isoform X8

    Related
    ENSP00000363853.3, ENST00000374721.7

  6. XM_047424629.1 → XP_047280585.1  cAMP-responsive element modulator isoform X7

  7. XM_006717387.4 → XP_006717450.1  cAMP-responsive element modulator isoform X6

    UniProtKB/Swiss-Prot
    A8K014, A8K3J7, A8K6A1, A8MPQ2, B4DXC1, C9J785, C9JZ10, E9PAR4, E9PHM1, O75519, Q03060, Q14501, Q14503, Q14504, Q14505, Q14506, Q15731, Q16114, Q16116, Q5T9H7, Q5W1A6, Q5W1A7, Q5W1A8, Q5W1A9, Q5W1B0
    Conserved Domains (2) summary
    cd14690
    Location:255 → 309
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:68 → 105
    pKID; pKID domain

  8. XM_011519324.3 → XP_011517626.1  cAMP-responsive element modulator isoform X5

    See identical proteins and their annotated locations for XP_011517626.1

    UniProtKB/Swiss-Prot
    A8K014, A8K3J7, A8K6A1, A8MPQ2, B4DXC1, C9J785, C9JZ10, E9PAR4, E9PHM1, O75519, Q03060, Q14501, Q14503, Q14504, Q14505, Q14506, Q15731, Q16114, Q16116, Q5T9H7, Q5W1A6, Q5W1A7, Q5W1A8, Q5W1A9, Q5W1B0
    Conserved Domains (2) summary
    cd14690
    Location:255 → 309
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:68 → 105
    pKID; pKID domain

  9. XM_006717382.4 → XP_006717445.1  cAMP-responsive element modulator isoform X11

    See identical proteins and their annotated locations for XP_006717445.1

    UniProtKB/TrEMBL
    G5E998
    Conserved Domains (2) summary
    cd14690
    Location:180 → 234
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:68 → 105
    pKID; pKID domain

  10. XM_017015731.2 → XP_016871220.1  cAMP-responsive element modulator isoform X14

    Conserved Domains (1) summary
    cd14690
    Location:93 → 147
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  11. XM_047424626.1 → XP_047280582.1  cAMP-responsive element modulator isoform X1

  12. XM_011519325.4 → XP_011517627.1  cAMP-responsive element modulator isoform X5

    See identical proteins and their annotated locations for XP_011517627.1

    UniProtKB/Swiss-Prot
    A8K014, A8K3J7, A8K6A1, A8MPQ2, B4DXC1, C9J785, C9JZ10, E9PAR4, E9PHM1, O75519, Q03060, Q14501, Q14503, Q14504, Q14505, Q14506, Q15731, Q16114, Q16116, Q5T9H7, Q5W1A6, Q5W1A7, Q5W1A8, Q5W1A9, Q5W1B0
    Related
    ENSP00000420511.1, ENST00000479070.5
    Conserved Domains (2) summary
    cd14690
    Location:255 → 309
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:68 → 105
    pKID; pKID domain

  13. XM_047424632.1 → XP_047280588.1  cAMP-responsive element modulator isoform X14

  14. XM_047424636.1 → XP_047280592.1  cAMP-responsive element modulator isoform X17

    UniProtKB/TrEMBL
    E9PB41

  15. XM_047424631.1 → XP_047280587.1  cAMP-responsive element modulator isoform X13

  16. XM_011519333.2 → XP_011517635.1  cAMP-responsive element modulator isoform X13

    Conserved Domains (1) summary
    cd14690
    Location:134 → 188
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  17. XM_011519330.3 → XP_011517632.1  cAMP-responsive element modulator isoform X9

    Conserved Domains (2) summary
    cd14690
    Location:200 → 254
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:13 → 50
    pKID; pKID domain

  18. XM_011519331.3 → XP_011517633.1  cAMP-responsive element modulator isoform X10

    Conserved Domains (1) summary
    cd14690
    Location:188 → 242
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  19. XM_011519332.3 → XP_011517634.1  cAMP-responsive element modulator isoform X12

    Conserved Domains (1) summary
    cd14690
    Location:176 → 230
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  20. XM_011519335.3 → XP_011517637.1  cAMP-responsive element modulator isoform X14

    See identical proteins and their annotated locations for XP_011517637.1

    Conserved Domains (1) summary
    cd14690
    Location:93 → 147
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  21. XM_047424634.1 → XP_047280590.1  cAMP-responsive element modulator isoform X16

  22. XM_047424635.1 → XP_047280591.1  cAMP-responsive element modulator isoform X16

  23. XM_047424637.1 → XP_047280593.1  cAMP-responsive element modulator isoform X17

    UniProtKB/TrEMBL
    E9PB41

  24. XM_047424633.1 → XP_047280589.1  cAMP-responsive element modulator isoform X15

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    35155414..35241554
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054364838.1 → XP_054220813.1  cAMP-responsive element modulator isoform X2

  2. XM_054364836.1 → XP_054220811.1  cAMP-responsive element modulator isoform X1

  3. XM_054364840.1 → XP_054220815.1  cAMP-responsive element modulator isoform X4

  4. XM_054364839.1 → XP_054220814.1  cAMP-responsive element modulator isoform X3

  5. XM_054364845.1 → XP_054220820.1  cAMP-responsive element modulator isoform X8

  6. XM_054364844.1 → XP_054220819.1  cAMP-responsive element modulator isoform X7

  7. XM_054364843.1 → XP_054220818.1  cAMP-responsive element modulator isoform X6

  8. XM_054364841.1 → XP_054220816.1  cAMP-responsive element modulator isoform X5

  9. XM_054364848.1 → XP_054220823.1  cAMP-responsive element modulator isoform X11

  10. XM_054364854.1 → XP_054220829.1  cAMP-responsive element modulator isoform X14

  11. XM_054364837.1 → XP_054220812.1  cAMP-responsive element modulator isoform X1

  12. XM_054364842.1 → XP_054220817.1  cAMP-responsive element modulator isoform X5

  13. XM_054364853.1 → XP_054220828.1  cAMP-responsive element modulator isoform X14

  14. XM_054364858.1 → XP_054220833.1  cAMP-responsive element modulator isoform X17

    UniProtKB/TrEMBL
    E9PB41

  15. XM_054364850.1 → XP_054220825.1  cAMP-responsive element modulator isoform X13

  16. XM_054364851.1 → XP_054220826.1  cAMP-responsive element modulator isoform X13

  17. XM_054364846.1 → XP_054220821.1  cAMP-responsive element modulator isoform X9

  18. XM_054364847.1 → XP_054220822.1  cAMP-responsive element modulator isoform X10

  19. XM_054364849.1 → XP_054220824.1  cAMP-responsive element modulator isoform X12

  20. XM_054364852.1 → XP_054220827.1  cAMP-responsive element modulator isoform X14

  21. XM_054364856.1 → XP_054220831.1  cAMP-responsive element modulator isoform X16

  22. XM_054364857.1 → XP_054220832.1  cAMP-responsive element modulator isoform X16

  23. XM_054364859.1 → XP_054220834.1  cAMP-responsive element modulator isoform X17

    UniProtKB/TrEMBL
    E9PB41

  24. XM_054364855.1 → XP_054220830.1  cAMP-responsive element modulator isoform X15

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_182722.1: Suppressed sequence

    Description
    NM_182722.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.

  2. NM_182725.1: Suppressed sequence

    Description
    NM_182725.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.

  3. NM_182850.2: Suppressed sequence

    Description
    NM_182850.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.

  4. NM_182853.2: Suppressed sequence

    Description
    NM_182853.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03060.6 GenPept UniProtKB/Swiss-Prot:Q03060

Gene LinkOut

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