Fau FAU ubiquitin like and ribosomal protein S30 fusion [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fauprovided by MGI
Official Full Name: FAU ubiquitin like and ribosomal protein S30 fusionprovided by MGI
Primary source: MGI:MGI:102547
See related: Ensembl:ENSMUSG00000038274 AllianceGenome:MGI:102547
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MNSFB; MNSFbeta
Summary: Predicted to be a structural constituent of ribosome. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide and defense response to Gram-positive bacterium. Predicted to be located in cytosolic ribosome and extracellular space. Predicted to be part of cytosolic small ribosomal subunit. Is expressed in decidua; embryo; and uterus. Orthologous to human FAU (FAU ubiquitin like and ribosomal protein S30 fusion). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in spleen adult (RPKM 573.2), ovary adult (RPKM 507.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 4.34 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (6107977..6109554)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (6057947..6059524)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MALDI-TOF mass spectrometry fingerprinting revealed that this MNSFbeta adduct consists of an 8.5 kDa MNSFbeta and heat shock protein 60 (HSP60), a mitochondrial protein involved in protein folding.
Title: Heat shock protein 60 negatively regulates the biological functions of ubiquitin-like protein MNSFβ in macrophages.
the association of MNSFbeta with HSPA8 may promote RANKL-induced osteoclastogenesis.
Title: Ubiquitin-like protein MNSFβ noncovalently binds to molecular chaperone HSPA8 and regulates osteoclastogenesis.
Collectively, MNSFbeta/FDH complex formation may positively regulate apoptosis in thymocytes.
Title: Ubiquitin-like protein MNSFβ covalently binds to cytosolic 10-formyltetrahydrofolate dehydrogenase and regulates thymocyte function.
these results demonstrated that a deficiency in MNSFb is associated with pregnancy loss, probably through reduced P53 and/or increased TNFA production at the fetal-maternal interface.
Title: Deficiency of monoclonal non-specific suppressor factor beta (MNSFB) promotes pregnancy loss in mice.
CD3/CD28-inducible MNSFbeta-Bcl-G complex may be involved in the regulation of T cell function and survival.
Title: Ubiquitin-like protein MNSFβ negatively regulates T cell function and survival.
MNSFbeta may bind to novel target proteins and negatively regulate TLR-2-mediated signal transduction in macrophages.
Title: Ubiquitin-like protein MNSFβ regulates TLR-2-mediated signal transduction.
these results demonstrate that MNSFbeta/endophilin II inhibits the signal pathway upstream of IKK activation, but not downstream of TLR2 signaling.
Title: Ubiquitin-like protein MNSFβ/endophilin II complex regulates Dectin-1-mediated phagocytosis and inflammatory responses in macrophages.
The result suggested that the level of MNSFbeta in interimplantation sites was significantly higher as compared with implantation sites in the mouse uterine on Day 4.5 of pregnancy
Title: [Expression of monoclonal nonspecific suppressor factor beta in E. coli, preparation of its antibodies and its tissue orientation in the mouse endometrium].
post-translational modification of endophilin II by MNSFbeta might be implicated in phagocytosis by macrophages.
Title: The ubiquitin-like protein monoclonal nonspecific suppressor factor beta conjugates to endophilin II and regulates phagocytosis.
These results demonstrate that MNSFbeta plays critical roles during the early pregnancy via multiple pathways
Title: Immunoneutralization of endometrial monoclonal nonspecific suppressor factor beta (MNSFbeta) inhibits mouse embryo implantation in vivo.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH93189 (e-PCR)
- UniSTS:84193

RH142169 (e-PCR)
- UniSTS:231421

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tag activity	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of ribosome	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in antibacterial humoral response	ISO Inferred from Sequence Orthology more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA Inferred from Direct Assay more info	PubMed
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
involved_in cytoplasmic translation	NAS Non-traceable Author Statement more info	PubMed
involved_in defense response to Gram-positive bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
involved_in innate immune response in mucosa	ISO Inferred from Sequence Orthology more info
involved_in modification-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosomal small subunit assembly	ISO Inferred from Sequence Orthology more info
involved_in translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	NAS Non-traceable Author Statement more info	PubMed
located_in cytosolic ribosome	ISO Inferred from Sequence Orthology more info
part_of cytosolic small ribosomal subunit	IDA Inferred from Direct Assay more info	PubMed
part_of cytosolic small ribosomal subunit	ISO Inferred from Sequence Orthology more info
part_of cytosolic small ribosomal subunit	NAS Non-traceable Author Statement more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
located_in ribosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ubiquitin-like FUBI-ribosomal protein eS30 fusion protein

Names: 40S ribosomal protein S30; FAU ubiquitin-like and ribosomal protein S30; Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived); MNSF-beta; monoclonal non-specific suppressor factor beta; monoclonal nonspecific suppressor factor beta; monoclonal nonspecific suppressor factor betamonoclonal nonspecific suppressor factor beta; ubiquitin-like protein FUBI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001160239.3 → NP_001153711.1 ubiquitin-like FUBI-ribosomal protein eS30 fusion protein

See identical proteins and their annotated locations for NP_001153711.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 3. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AC131692

Consensus CDS

CCDS29489.1

UniProtKB/Swiss-Prot

P35545, P62862, Q642K5, Q9JJ24

UniProtKB/TrEMBL

Q3THB2

Related

ENSMUSP00000042835.6, ENSMUST00000043074.14

Conserved Domains (2) summary

cd01793
Location:1 → 74

Ubl_FUBI; ubiquitin-like (Ubl) domain found in ubiquitin-like protein FUBI and similar proteins

pfam04758
Location:75 → 132

Ribosomal_S30; Ribosomal protein S30
NM_001190436.2 → NP_001177365.1 ubiquitin-like FUBI-ribosomal protein eS30 fusion protein

See identical proteins and their annotated locations for NP_001177365.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AC131692

Consensus CDS

CCDS29489.1

UniProtKB/Swiss-Prot

P35545, P62862, Q642K5, Q9JJ24

UniProtKB/TrEMBL

Q3THB2

Related

ENSMUSP00000136358.2, ENSMUST00000179142.2

Conserved Domains (2) summary

cd01793
Location:1 → 74

Ubl_FUBI; ubiquitin-like (Ubl) domain found in ubiquitin-like protein FUBI and similar proteins

pfam04758
Location:75 → 132

Ribosomal_S30; Ribosomal protein S30
NM_007990.4 → NP_032016.1 ubiquitin-like FUBI-ribosomal protein eS30 fusion protein

See identical proteins and their annotated locations for NP_032016.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 3. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AC131692

Consensus CDS

CCDS29489.1

UniProtKB/Swiss-Prot

P35545, P62862, Q642K5, Q9JJ24

UniProtKB/TrEMBL

Q3THB2

Related

ENSMUSP00000136803.2, ENSMUST00000178310.9

Conserved Domains (2) summary

cd01793
Location:1 → 74

Ubl_FUBI; ubiquitin-like (Ubl) domain found in ubiquitin-like protein FUBI and similar proteins

pfam04758
Location:75 → 132

Ribosomal_S30; Ribosomal protein S30