Fgf5 fibroblast growth factor 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fgf5provided by MGI
Official Full Name: fibroblast growth factor 5provided by MGI
Primary source: MGI:MGI:95519
See related: Ensembl:ENSMUSG00000029337 AllianceGenome:MGI:95519
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: go; Fgf-5; Fgf3a; HBGF-5; angora
Summary: This gene encodes a secreted protein that is a member of a family of heparin-binding growth factors. The encoded protein regulates cell proliferation, particularly the growth of hair follicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 5 E3; 5 47.77 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (98402108..98424892)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (98254184..98277033)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FGF5 alleviated acute lung injury via AKT signal pathway in endothelial cells.
Title: FGF5 alleviated acute lung injury via AKT signal pathway in endothelial cells.
Gender-Difference in Hair Length as Revealed by Crispr-Based Production of Long-Haired Mice with Dysfunctional FGF5 Mutations.
Title: Gender-Difference in Hair Length as Revealed by Crispr-Based Production of Long-Haired Mice with Dysfunctional FGF5 Mutations.
SP1-induced lncRNA TUG1 regulates proliferation and apoptosis in islet cells of type 2 diabetes mellitus via the miR-188-3p/FGF5 axis.
Title: SP1-induced lncRNA TUG1 regulates proliferation and apoptosis in islet cells of type 2 diabetes mellitus via the miR-188-3p/FGF5 axis.
Temporal dissection of an enhancer cluster reveals distinct temporal and functional contributions of individual elements.
Title: Temporal dissection of an enhancer cluster reveals distinct temporal and functional contributions of individual elements.
Etv5 can positively regulate primitive endoderm specification through regulating Gata6 and negatively regulate epiblast specification by inhibiting Fgf5 expression.
Title: The oncogene Etv5 promotes MET in somatic reprogramming and orchestrates epiblast/primitive endoderm specification during mESCs differentiation.
Recruited CD11b+ CD68+ Kupffer cells/Mphis may play an essential role in steatohepatitis and fibrosis in FGF5 null mice fed with a HFD. Recruitment and activation of bone marrow derived Mphis is the key factor to develop steatohepatitis from simple steatosis.
Title: Activation and increase of radio-sensitive CD11b+ recruited Kupffer cells/macrophages in diet-induced steatohepatitis in FGF5 deficient mice.
It participates in the progression of hepatic fibrosis.
Title: Fibroblast growth factor-5 participates in the progression of hepatic fibrosis.
Interaction of mutant genes Fgf5(go-Y), we, and wal changes the duration of hair growth cycles in mice
Title: [Interaction of mutant genes Fgf5(go-Y), we, and wal changes the duration of hair growth cycles in mice].
A deletion of a 9.3-kb region in the Fgf5 gene showed insertion of a 498-bp early transposon element long terminal repeat. Results show that long hair mutation of moja/moja mice is caused by Fgf5 disruption mediated by retrotransposon insertion.
Title: Retrotransposon-mediated Fgf5(go-Utr) mutant mice with long pelage hair.
Fluctuations of BMP2 signaling pathway during hair cycles in skin with mutant genes we, wal and Fgf5(go).
Title: Fluctuations of BMP signaling pathway during hair cycles in skin of mice with mutant genes we, wal and Fgf5(go).

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (3) 1 citation
Targeted (2) 1 citation
Chemically induced (ENU) (2)
Endonuclease-mediated (5) 1 citation

General gene information

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Markers

Fgf5 (e-PCR), detects polymorphism
- UniSTS:516620

Fgf5 (e-PCR), detects polymorphism
- UniSTS:546578

Fgf5 (e-PCR), detects polymorphism
- UniSTS:507928

M37823 (e-PCR)
- UniSTS:124954

Fgf5 (e-PCR), detects polymorphism
- UniSTS:166214

Fgf5 (e-PCR), detects polymorphism
- UniSTS:464786

Fgf5 (e-PCR), detects polymorphism
- UniSTS:258271

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables fibroblast growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables fibroblast growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in fibroblast growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of cell division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction involved in regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: fibroblast growth factor 5

Names: fibroblast growth factor 3a; heparin-binding growth factor 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001277268.2 → NP_001264197.1 fibroblast growth factor 5 isoform 2 precursor

See identical proteins and their annotated locations for NP_001264197.1

Status: VALIDATED

Source sequence(s)

AC125073

Consensus CDS

CCDS80344.1

UniProtKB/Swiss-Prot

P15656

Related

ENSMUSP00000142420.2, ENSMUST00000200059.2

Conserved Domains (1) summary

cl00060
Location:85 → 114

FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
NM_010203.6 → NP_034333.1 fibroblast growth factor 5 isoform 1 precursor

See identical proteins and their annotated locations for NP_034333.1

Status: VALIDATED

Source sequence(s)

AC125073

Consensus CDS

CCDS19455.1

UniProtKB/Swiss-Prot

O88825, P15656

UniProtKB/TrEMBL

A0A7U3L698

Related

ENSMUSP00000031280.2, ENSMUST00000031280.2

Conserved Domains (1) summary

pfam00167
Location:85 → 214

FGF; Fibroblast growth factor