Fhl1 four and a half LIM domains 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fhl1provided by MGI
Official Full Name: four and a half LIM domains 1provided by MGI
Primary source: MGI:MGI:1298387
See related: Ensembl:ENSMUSG00000023092 AllianceGenome:MGI:1298387
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: KyoT; SLIM; FHL-1; SLIM-1; RAM14-1
Summary: Predicted to enable transmembrane transporter binding activity. Predicted to be involved in several processes, including negative regulation of mitotic cell cycle phase transition; regulation of membrane depolarization; and regulation of potassium ion transport. Predicted to act upstream of or within cell differentiation. Predicted to be located in cytosol; nucleus; and plasma membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Used to study scapuloperoneal myopathy. Human ortholog(s) of this gene implicated in Uruguay faciocardiomusculoskeletal syndrome; X-linked Emery-Dreifuss muscular dystrophy 6; reducing body myopathy 1A; and reducing body myopathy 1B. Orthologous to human FHL1 (four and a half LIM domains 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in bladder adult (RPKM 335.4), lung adult (RPKM 134.7) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A6; X 30.06 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (55776569..55838704)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (56731209..56793346)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FHL1 promotes chikungunya and o'nyong-nyong virus infection and pathogenesis with implications for alphavirus vaccine design.
Title: FHL1 promotes chikungunya and o'nyong-nyong virus infection and pathogenesis with implications for alphavirus vaccine design.
MiR-183-5p induced by saturated fatty acids regulates the myogenic differentiation by directly targeting FHL1 in C2C12 myoblasts.
Title: MiR-183-5p induced by saturated fatty acids regulates the myogenic differentiation by directly targeting FHL1 in C2C12 myoblasts.
FHL1 is a key player of chikungunya virus tropism and pathogenesis.
Title: FHL1 is a key player of chikungunya virus tropism and pathogenesis.
Systemic effect of FHL1 on neuromuscular junction and myotube formation via insulin-like growth factor and myostatin signaling pathways.
Title: Systemic effect of FHL1 on neuromuscular junction and myotube formation via insulin-like growth factor and myostatin signaling pathways.
FHL-1 is not involved in pressure overload-induced maladaptive right ventricular remodeling and dysfunction.
Title: FHL-1 is not involved in pressure overload-induced maladaptive right ventricular remodeling and dysfunction.
Muscle death participates in myofibrillar abnormalities in FHL1 knockout mice.
Title: Muscle death participates in myofibrillar abnormalities in FHL1 knockout mice.
study shows that FHL1 is a key factor expressed by the host that enables chikungunya virus (CHIKV) infection and identifies the interaction between nsP3 and FHL1 as a promising target for the development of anti-CHIKV therapies
Title: FHL1 is a major host factor for chikungunya virus infection.
mutant mice harboring the missense mutation p.W122S in Fhl1 gene developed late-onset cardiac dysfunction without skeletal myopathy
Title: Cardiomyopathy and altered integrin-actin signaling in Fhl1 mutant female mice.
KyoT2 downregulates airway remodeling and resistance in asthmatic mice through a Hes1-dependent mechanism.
Title: KyoT2 downregulates airway remodeling in asthma.
Results found that osteogenesis increases with the overexpression of Fhl1 and decreases with reduced Fhl1 expression and suggest that Fhl1 mediates interacting estrogen and Wnt signaling during osteogenesis.
Title: Estrogen enhances activity of Wnt signaling during osteogenesis by inducing Fhl1 expression.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Fhl1 (e-PCR), detects polymorphism
- UniSTS:506893

Fhl1 (e-PCR), detects polymorphism
- UniSTS:472852

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in muscle organ development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of potassium ion transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane depolarization	ISO Inferred from Sequence Orthology more info
involved_in regulation of potassium ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: four and a half LIM domains protein 1

Names: RBP-associated molecule 14-1; skeletal muscle LIM-protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077361.2 → NP_001070829.1 four and a half LIM domains protein 1 isoform 1

See identical proteins and their annotated locations for NP_001070829.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AL671998

Consensus CDS

CCDS40981.1

UniProtKB/TrEMBL

A2AEY2

Related

ENSMUSP00000110417.3, ENSMUST00000114769.9

Conserved Domains (4) summary

cd09344
Location:40 → 93

LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1

cd09424
Location:101 → 158

LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09429
Location:162 → 214

LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)

cl02475
Location:5 → 33

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001077362.3 → NP_001070830.1 four and a half LIM domains protein 1 isoform 2

See identical proteins and their annotated locations for NP_001070830.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) represents the use of an alternate promoter, differs in the 5' and 3' UTRs and lacks an exon in the 3' coding region resulting in a translational frameshift compared to variant 1. The encoded protein (isoform 2) has a longer N-terminus, a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AL671998

Consensus CDS

CCDS40980.1

UniProtKB/TrEMBL

A2AEX6, A2AEX8

Related

ENSMUSP00000110420.3, ENSMUST00000114772.9

Conserved Domains (5) summary

cd09344
Location:56 → 109

LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1

cd09348
Location:233 → 296

LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09424
Location:117 → 174

LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09429
Location:178 → 230

LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)

cl02475
Location:21 → 49

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001287800.2 → NP_001274729.1 four and a half LIM domains protein 1 isoform 3

See identical proteins and their annotated locations for NP_001274729.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) represents the use of an alternate promoter, differs in the 5' and 3' UTRs and lacks an exon in the 3' coding region resulting in a translational frameshift compared to variant 1. The encoded protein (isoform 3, also known as KyoT1) has a distinct C-terminus and is shorter than isoform 1. Variants 3 and 4 encode the same protein.

Source sequence(s)

AL671998

Consensus CDS

CCDS30148.1

UniProtKB/Swiss-Prot

O55181, P97447, Q8K318

UniProtKB/TrEMBL

A2AEX6

Related

ENSMUSP00000110421.4, ENSMUST00000114773.10

Conserved Domains (5) summary

cd09344
Location:40 → 93

LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1

cd09348
Location:217 → 280

LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09424
Location:101 → 158

LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09429
Location:162 → 214

LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)

cl02475
Location:5 → 33

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001412079.1 → NP_001399008.1 four and a half LIM domains protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

AL671998

UniProtKB/TrEMBL

A2AEY2
NM_001412080.1 → NP_001399009.1 four and a half LIM domains protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

AL671998

UniProtKB/TrEMBL

A2AEY2
NM_001412081.1 → NP_001399010.1 four and a half LIM domains protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

AL671998

UniProtKB/TrEMBL

A2AEY2
NM_001412082.1 → NP_001399011.1 four and a half LIM domains protein 1 isoform 3

Status: VALIDATED

Source sequence(s)

AL671998

UniProtKB/Swiss-Prot

O55181, P97447, Q8K318

Related

ENSMUSP00000112295.2, ENSMUST00000116596.8
NM_001412083.1 → NP_001399012.1 four and a half LIM domains protein 1 isoform 4

Status: VALIDATED

Source sequence(s)

AL671998
NM_001412084.1 → NP_001399013.1 four and a half LIM domains protein 1 isoform 5

Status: VALIDATED

Source sequence(s)

AL671998
NM_001412085.1 → NP_001399014.1 four and a half LIM domains protein 1 isoform 6

Status: VALIDATED

Source sequence(s)

AL671998

UniProtKB/TrEMBL

A2AEX7

Related

ENSMUSP00000110416.4, ENSMUST00000114768.10
NM_001412086.1 → NP_001399015.1 four and a half LIM domains protein 1 isoform 7

Status: VALIDATED

Source sequence(s)

AL671998
NM_001412087.1 → NP_001399016.1 four and a half LIM domains protein 1 isoform 7

Status: VALIDATED

Source sequence(s)

AL671998
NM_001412088.1 → NP_001399017.1 four and a half LIM domains protein 1 isoform 7

Status: VALIDATED

Source sequence(s)

AL671998
NM_010211.4 → NP_034341.2 four and a half LIM domains protein 1 isoform 3

See identical proteins and their annotated locations for NP_034341.2

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' and 3' UTRs and lacks an exon in the 3' coding region resulting in a translational frameshift compared to variant 1. The encoded protein (isoform 3, also known as KyoT1) has a distinct C-terminus and is shorter than isoform 1. Variants 3 and 4 encode the same protein.

Source sequence(s)

AL671998

Consensus CDS

CCDS30148.1

UniProtKB/Swiss-Prot

O55181, P97447, Q8K318

UniProtKB/TrEMBL

A2AEX6

Related

ENSMUSP00000023854.4, ENSMUST00000023854.10

Conserved Domains (5) summary

cd09344
Location:40 → 93

LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1

cd09348
Location:217 → 280

LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09424
Location:101 → 158

LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09429
Location:162 → 214

LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)

cl02475
Location:5 → 33

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

55776569..55838704

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030251223.2 → XP_030107083.1 four and a half LIM domains protein 1 isoform X3

UniProtKB/Swiss-Prot

O55181, P97447, Q8K318

UniProtKB/TrEMBL

A2AEX6

Conserved Domains (5) summary

cd09344
Location:40 → 93

LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1

cd09348
Location:217 → 280

LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09424
Location:101 → 158

LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09429
Location:162 → 214

LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)

cl02475
Location:5 → 33

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
XM_030251225.2 → XP_030107085.1 four and a half LIM domains protein 1 isoform X5

Conserved Domains (3) summary

cd09344
Location:40 → 93

LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1

cd09424
Location:101 → 158

LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)

cl02475
Location:5 → 33

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
XM_006527805.3 → XP_006527868.1 four and a half LIM domains protein 1 isoform X1

See identical proteins and their annotated locations for XP_006527868.1

UniProtKB/TrEMBL

A2AEY2

Conserved Domains (4) summary

cd09344
Location:40 → 93

LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1

cd09424
Location:101 → 158

LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09429
Location:162 → 214

LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)

cl02475
Location:5 → 33

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
XM_006527807.2 → XP_006527870.2 four and a half LIM domains protein 1 isoform X4

UniProtKB/TrEMBL

A2AEY1

Related

ENSMUSP00000116725.2, ENSMUST00000144600.8

Conserved Domains (4) summary

cd09344
Location:40 → 93

LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1

cd09424
Location:101 → 158

LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09429
Location:162 → 214

LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)

cl02475
Location:5 → 33

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
XM_006527804.2 → XP_006527867.1 four and a half LIM domains protein 1 isoform X1

See identical proteins and their annotated locations for XP_006527867.1

UniProtKB/TrEMBL

A2AEY2

Conserved Domains (4) summary

cd09344
Location:40 → 93

LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1

cd09424
Location:101 → 158

LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09429
Location:162 → 214

LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)

cl02475
Location:5 → 33

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers