SESN3 sestrin 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SESN3provided by HGNC
Official Full Name: sestrin 3provided by HGNC
Primary source: HGNC:HGNC:23060
See related: Ensembl:ENSG00000149212 MIM:607768; AllianceGenome:HGNC:23060
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SEST3
Summary: This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
Expression: Ubiquitous expression in brain (RPKM 14.9), lymph node (RPKM 14.4) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q21

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (95165513..95232475, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (95172632..95239638, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (94898677..94965639, complement)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic variations in a Sestrin2/Sestrin3/mTOR Axis and development of new-onset diabetes after kidney transplantation.
Title: Genetic variations in a Sestrin2/Sestrin3/mTOR Axis and development of new-onset diabetes after kidney transplantation.
The functions and roles of sestrins in regulating human diseases.
Title: The functions and roles of sestrins in regulating human diseases.
Oncogenic role of early growth response-1 in liver cancer through the regulation of the microRNA-675/sestrin 3 and the Wnt/beta-catenin signaling pathway.
Title: Oncogenic role of early growth response-1 in liver cancer through the regulation of the microRNA-675/sestrin 3 and the Wnt/β-catenin signaling pathway.
Colon and liver tissue damage detection using methylated SESN3 and PTK2B genes in circulating cell-free DNA in patients with acute graft-versus-host disease.
Title: Colon and liver tissue damage detection using methylated SESN3 and PTK2B genes in circulating cell-free DNA in patients with acute graft-versus-host disease.
Circulating Sestrin Levels Are Increased in Hypertension Patients.
Title: Circulating Sestrin Levels Are Increased in Hypertension Patients.
identified new interactions between miR-200 and the oxidative stress response SESN proteins that affect anoikis resistance in human endometrial cancer cells.
Title: Interactions between microRNA-200 family and Sestrin proteins in endometrial cancer cell lines and their significance to anoikis.
It is possible that the over expression of the SESN3 gene, known to suppress oxidative damage, may have contributed to the attenuation of fatigue in Puerto Rican Men during Radiotherapy for Prostate Cancer
Title: Gene Expression, and Fatigue in Puerto Rican Men during Radiotherapy for Prostate Cancer: an Exploratory Study.
Results suggest that Sesn3 is a target gene for rno-miR-155. Moreover, the rno-miR-155 antagonist may induce the expression of Sesn3, and then indirectly decrease the damage of oxidative stress to protect the brain from epileptogenesis-associated impairments.
Title: Silencing rno-miR-155-5p in rat temporal lobe epilepsy model reduces pathophysiological features and cell apoptosis by activating Sestrin-3.
The expression of SESN3 and (TSC2 and FOXO1) was identified in Lewy bodies from brainstem.
Title: Autophagy mediators (FOXO1, SESN3 and TSC2) in Lewy body disease and aging.
in FOXO3-death-resistant cells no point mutations in the TP53-DBD were found-in these cells FOXO3-TP53 complexes are formed and FOXO3-binding to the BIM-promoter, but not the induction of the detoxifying protein SESN3, were prevented, which in turn increased chemo-protection in this type of high-stage-derived neuroblastoma (NB)cells
Title: FOXO3-mediated chemo-protection in high-stage neuroblastoma depends on wild-type TP53 and SESN3.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SGC34501 (e-PCR)
- UniSTS:28672

RH18334 (e-PCR)
- UniSTS:30982

RH47318 (e-PCR)
- UniSTS:70988

D11S2315E (e-PCR)
- UniSTS:78418

RH46209 (e-PCR)
- UniSTS:1619

D11S361 (e-PCR)
- UniSTS:11091

SHGC-111463 (e-PCR)
- UniSTS:182358

SHGC-111507 (e-PCR)
- UniSTS:182360

G33064 (e-PCR)
- UniSTS:117640

RH68616 (e-PCR)
- UniSTS:20128

WI-16429 (e-PCR)
- UniSTS:77475

D11S4631 (e-PCR)
- UniSTS:21677

RH48984 (e-PCR)
- UniSTS:48850

RH11849 (e-PCR)
- UniSTS:21997

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables L-leucine binding	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity, acting on peroxide as acceptor	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in TORC2 signaling	IEA Inferred from Electronic Annotation more info
involved_in cellular response to L-leucine	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to amino acid starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to glucose starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to leucine starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in glucose homeostasis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of TORC1 signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macroautophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of response to reactive oxygen species	IEA Inferred from Electronic Annotation more info
involved_in response to insulin	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of GATOR2 complex	IDA Inferred from Direct Assay more info	PubMed
part_of TORC2 complex	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sestrin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271594.2 → NP_001258523.1 sestrin-3 isoform 2

See identical proteins and their annotated locations for NP_001258523.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site compared to variant 1. It encodes a shorter protein (isoform 2) compared to isoform 1.

Source sequence(s)

AK302366, AP000787

Consensus CDS

CCDS60938.1

UniProtKB/Swiss-Prot

P58005

Related

ENSP00000278499.2, ENST00000278499.6

Conserved Domains (1) summary

pfam04636
Location:1 → 351

PA26; PA26 p53-induced protein (sestrin)
NM_144665.4 → NP_653266.2 sestrin-3 isoform 1

See identical proteins and their annotated locations for NP_653266.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AF086251, AK096300, AP000787

Consensus CDS

CCDS8303.1

UniProtKB/Swiss-Prot

B7Z7P9, P58005, Q96AD1

Related

ENSP00000441927.1, ENST00000536441.7

Conserved Domains (1) summary

pfam04636
Location:39 → 490

PA26; PA26 p53-induced protein (sestrin)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000011.10 Reference GRCh38.p14 Primary Assembly

Range

95165513..95232475 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011542614.2 → XP_011540916.1 sestrin-3 isoform X1

Conserved Domains (1) summary

pfam04636
Location:16 → 467

PA26; PA26 p53-induced protein (sestrin)
XM_024448355.2 → XP_024304123.1 sestrin-3 isoform X2

Conserved Domains (1) summary

pfam04636
Location:1 → 412

PA26; PA26 p53-induced protein (sestrin)
XM_047426416.1 → XP_047282372.1 sestrin-3 isoform X2