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Hagh hydroxyacyl glutathione hydrolase [ Mus musculus (house mouse) ]

Gene ID: 14651, updated on 3-Apr-2024

Summary

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Official Symbol
Haghprovided by MGI
Official Full Name
hydroxyacyl glutathione hydrolaseprovided by MGI
Primary source
MGI:MGI:95745
See related
Ensembl:ENSMUSG00000024158 AllianceGenome:MGI:95745
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Glo2; Glo-2; Rsp29
Summary
Enables hydroxyacylglutathione hydrolase activity. Predicted to be involved in carbohydrate metabolic process and glutathione biosynthetic process. Predicted to act upstream of or within methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human HAGH (hydroxyacylglutathione hydrolase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver adult (RPKM 156.6), kidney adult (RPKM 107.1) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 A3.3; 17 12.53 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25056863..25083424)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24839781..24864450)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E265 Neighboring gene methionine sulfoxide reductase B1 Neighboring gene heparan sulfate (glucosamine) 3-O-sulfotransferase 6 Neighboring gene meiosis specific with OB domains Neighboring gene STARR-positive B cell enhancer ABC_E486 Neighboring gene fumarylacetoacetate hydrolase domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_42099 Neighboring gene STARR-seq mESC enhancer starr_42100 Neighboring gene predicted gene, 41549 Neighboring gene STARR-positive B cell enhancer ABC_E216 Neighboring gene insulin-like growth factor binding protein, acid labile subunit Neighboring gene nucleotide binding protein 2 Neighboring gene splA/ryanodine receptor domain and SOCS box containing 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hyperosmotic Stress Initiates AMPK-Independent Autophagy and AMPK- and Autophagy-Independent Depletion of Thioredoxin 1 and Glyoxalase 2 in HT22 Nerve Cells. Dafre AL, et al. Oxid Med Cell Longev, 2019. PMID 31049129, Free PMC Article
  2. Tat-glyoxalase protein inhibits against ischemic neuronal cell damage and ameliorates ischemic injury. Shin MJ, et al. Free Radic Biol Med, 2014 Feb. PMID 24252591
  3. Genomic rearrangement of the alpha-globin gene complex during mammalian evolution. Tan H, et al. Biochem Genet, 1993 Dec. PMID 8166621
  4. Role of the glyoxalase system in astrocyte-mediated neuroprotection. Bélanger M, et al. J Neurosci, 2011 Dec 14. PMID 22171037, Free PMC Article
  5. A quantitative genetic analysis of slow-wave sleep and rapid-eye movement sleep in CXB recombinant inbred mice. Toth LA, et al. Behav Genet, 1999 Sep. PMID 10765561

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hyperosmotic stress induced AMPK activation, but this was not responsible for its effects on mTOR activity or autophagy induction. Moreover, the decrease in Trx1 and Glo2 induced by hyperosmotic stress was independent of both autophagy and AMPK activation.
    Title: Hyperosmotic Stress Initiates AMPK-Independent Autophagy and AMPK- and Autophagy-Independent Depletion of Thioredoxin 1 and Glyoxalase 2 in HT22 Nerve Cells.
  2. Glyoxalase expression prevents against ischemic neuronal cell damage and ameliorates ischemic injury.
    Title: Tat-glyoxalase protein inhibits against ischemic neuronal cell damage and ameliorates ischemic injury.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydroxyacylglutathione hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydroxyacylglutathione hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydroxyacylglutathione hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within glutathione biosynthetic process IC
Inferred by Curator
more info
 PubMed 
involved_in glutathione biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutathione metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
hydroxyacylglutathione hydrolase, mitochondrial
Names
glx II
glyoxalase II
glyoxylase 2
round spermatid protein RSP29
NP_001153098.1
NP_001396515.1
NP_001396516.1
NP_001396517.1
NP_001396518.1
NP_001396519.1
NP_001396520.1
NP_001396521.1
NP_001396522.1
NP_001396523.1
NP_001396525.1
NP_001396526.1
NP_001396527.1
NP_001396528.1
NP_001396529.1
NP_001396530.1
NP_001396531.1
NP_001396532.1
NP_001396533.1
NP_001396534.1
NP_001396535.1
NP_001396536.1
NP_077246.2
XP_006523724.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159626.2 → NP_001153098.1  hydroxyacylglutathione hydrolase, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_001153098.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and CDS, and uses a downstream start codon compared to variant 1. Isoform 2 has a shorter N-terminus compared to isoform 1 and is a cytosolic protein.
    Source sequence(s)
    AC166102
    Consensus CDS
    CCDS50021.1
    UniProtKB/Swiss-Prot
    Q3TMR4, Q3UCF6, Q8WUR9, Q99KB8
    UniProtKB/TrEMBL
    A0A0R4J052
    Related
    ENSMUSP00000024974.10, ENSMUST00000024974.16
    Conserved Domains (1) summary
    PLN02469
    Location:1 → 256
    PLN02469; hydroxyacylglutathione hydrolase

  2. NM_001409586.1 → NP_001396515.1  hydroxyacylglutathione hydrolase, mitochondrial isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC166102

  3. NM_001409587.1 → NP_001396516.1  hydroxyacylglutathione hydrolase, mitochondrial isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC166102

  4. NM_001409588.1 → NP_001396517.1  hydroxyacylglutathione hydrolase, mitochondrial isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC166102

  5. NM_001409589.1 → NP_001396518.1  hydroxyacylglutathione hydrolase, mitochondrial isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC166102

  6. NM_001409590.1 → NP_001396519.1  hydroxyacylglutathione hydrolase, mitochondrial isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC166102

  7. NM_001409591.1 → NP_001396520.1  hydroxyacylglutathione hydrolase, mitochondrial isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC166102

  8. NM_001409592.1 → NP_001396521.1  hydroxyacylglutathione hydrolase, mitochondrial isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC166102

  9. NM_001409593.1 → NP_001396522.1  hydroxyacylglutathione hydrolase, mitochondrial isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC166102

  10. NM_001409594.1 → NP_001396523.1  hydroxyacylglutathione hydrolase, mitochondrial isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC166102

  11. NM_001409596.1 → NP_001396525.1  hydroxyacylglutathione hydrolase, mitochondrial isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC166102

  12. NM_001409597.1 → NP_001396526.1  hydroxyacylglutathione hydrolase, mitochondrial isoform 16

    Status: VALIDATED

    Source sequence(s)
    AC166102

  13. NM_001409598.1 → NP_001396527.1  hydroxyacylglutathione hydrolase, mitochondrial isoform 16

    Status: VALIDATED

    Source sequence(s)
    AC166102

  14. NM_001409599.1 → NP_001396528.1  hydroxyacylglutathione hydrolase, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC166102
    UniProtKB/TrEMBL
    A0A0R4J052

  15. NM_001409600.1 → NP_001396529.1  hydroxyacylglutathione hydrolase, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC166102
    UniProtKB/TrEMBL
    A0A0R4J052

  16. NM_001409601.1 → NP_001396530.1  hydroxyacylglutathione hydrolase, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC166102
    UniProtKB/TrEMBL
    A0A0R4J052

  17. NM_001409602.1 → NP_001396531.1  hydroxyacylglutathione hydrolase, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC166102
    UniProtKB/TrEMBL
    A0A0R4J052

  18. NM_001409603.1 → NP_001396532.1  hydroxyacylglutathione hydrolase, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC166102
    UniProtKB/TrEMBL
    A0A0R4J052

  19. NM_001409604.1 → NP_001396533.1  hydroxyacylglutathione hydrolase, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC166102
    UniProtKB/TrEMBL
    A0A0R4J052

  20. NM_001409605.1 → NP_001396534.1  hydroxyacylglutathione hydrolase, mitochondrial isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC166102

  21. NM_001409606.1 → NP_001396535.1  hydroxyacylglutathione hydrolase, mitochondrial isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC166102

  22. NM_001409607.1 → NP_001396536.1  hydroxyacylglutathione hydrolase, mitochondrial isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC166102

  23. NM_024284.3 → NP_077246.2  hydroxyacylglutathione hydrolase, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_077246.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1) which is localized to the mitochondria.
    Source sequence(s)
    AC166102
    Consensus CDS
    CCDS28499.2
    UniProtKB/Swiss-Prot
    Q3TMR4, Q3UCF6, Q8WUR9, Q99KB8
    UniProtKB/TrEMBL
    G5E8T9
    Related
    ENSMUSP00000113051.2, ENSMUST00000118788.8
    Conserved Domains (3) summary
    PLN02469
    Location:50 → 305
    PLN02469; hydroxyacylglutathione hydrolase
    pfam16123
    Location:223 → 303
    HAGH_C; Hydroxyacylglutathione hydrolase C-terminus
    cd07723
    Location:55 → 222
    hydroxyacylglutathione_hydrolase_MBL-fold; hydroxyacylglutathione hydrolase, MBL-fold metallo-hydrolase domain

RNA

  1. NR_176872.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC166102

  2. NR_176873.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC166102

  3. NR_176874.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC166102

  4. NR_176875.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC166102

  5. NR_176876.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC166102

  6. NR_176877.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC166102

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    25056863..25083424
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523661.3 → XP_006523724.1  hydroxyacylglutathione hydrolase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006523724.1

    UniProtKB/Swiss-Prot
    Q3TMR4, Q3UCF6, Q8WUR9, Q99KB8
    UniProtKB/TrEMBL
    A0A0R4J052
    Conserved Domains (1) summary
    PLN02469
    Location:1 → 256
    PLN02469; hydroxyacylglutathione hydrolase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99KB8.2 GenPept UniProtKB/Swiss-Prot:Q99KB8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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