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PCYB_053150 bifunctional dihydrofolate reductase-thymidylate synthase 1 [ Plasmodium cynomolgi strain B ]

Gene ID: 14691686, updated on 28-Dec-2023

Summary

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Gene symbol
PCYB_053150
Gene description
bifunctional dihydrofolate reductase-thymidylate synthase 1
Locus tag
PCYB_053150
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Plasmodium cynomolgi strain B (strain: B)
Lineage
Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodium; Plasmodium (Plasmodium)
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Genomic context

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Location:
chromosome: 5
Exon count:
1
Sequence:
NC_020398.1 (910571..912229)

NC_020398.1Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene RNA-binding protein of pumilio/mpt5 family Neighboring gene mitochondrial membrane protein Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_020398.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Plasmodium cynomolgi genome sequences provide insight into Plasmodium vivax and the monkey malaria clade. Tachibana S, et al. Nat Genet, 2012 Sep. PMID 22863735, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables dihydrofolate reductase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables thymidylate synthase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in dTMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in one-carbon metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tetrahydrofolate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Names
bifunctional dihydrofolate reductase-thymidylate synthase 1
XP_004221244.1
  • putative

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_020398.1 Reference assembly

    Range
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004221196.1 → XP_004221244.1  bifunctional dihydrofolate reductase-thymidylate synthase 1, partial [Plasmodium cynomolgi strain B]

    See identical proteins and their annotated locations for XP_004221244.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    K6V831, U3M190
    Conserved Domains (2) summary
    cd00209
    Location:37 → 241
    DHFR; Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5, ...
    pfam00303
    Location:345 → 553
    Thymidylat_synt; Thymidylate synthase
Nucleotide Protein
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