Gpx3 glutathione peroxidase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gpx3provided by MGI
Official Full Name: glutathione peroxidase 3provided by MGI
Primary source: MGI:MGI:105102
See related: Ensembl:ENSMUSG00000018339 AllianceGenome:MGI:105102
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GPx; EGPx; GSHPx-3; GSHPx-P
Summary: The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is secreted and is highly expressed in mouse kidney, which appears to be the major source of the enzyme in plasma. It has a role in mouse organogenesis, and dysregulation of this isozyme has been associated with obesity-related metabolic complications, platelet-dependent thrombosis, colitis-associated carcinoma, and thermosensitive phenotype. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2016]
Expression: Biased expression in kidney adult (RPKM 11946.2) and genital fat pad adult (RPKM 610.3) See more
Orthologs: human all
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Genomic context

Location:: 11 B1.3; 11 32.13 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (54793680..54801213)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (54902854..54910387)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GPx3 deficiency exacerbates maladaptive right ventricular remodeling in experimental pulmonary artery banding.
Title: GPx3 deficiency exacerbates maladaptive right ventricular remodeling in experimental pulmonary artery banding.
Vitamin D-vitamin D receptor alleviates oxidative stress in ischemic acute kidney injury via upregulating glutathione peroxidase 3.
Title: Vitamin D-vitamin D receptor alleviates oxidative stress in ischemic acute kidney injury via upregulating glutathione peroxidase 3.
Gpx3 and Egr1 Are Involved in Regulating the Differentiation Fate of Cardiac Fibroblasts under Pressure Overload.
Title: Gpx3 and Egr1 Are Involved in Regulating the Differentiation Fate of Cardiac Fibroblasts under Pressure Overload.
Loss of glutathione peroxidase 3 induces ROS and contributes to prostatic hyperplasia in Nkx3.1 knockout mice.
Title: Loss of glutathione peroxidase 3 induces ROS and contributes to prostatic hyperplasia in Nkx3.1 knockout mice.
GPx3 dysregulation impacts adipose tissue insulin receptor expression and sensitivity.
Title: GPx3 dysregulation impacts adipose tissue insulin receptor expression and sensitivity.
GPx3 deficiency is a substantive contributing factor to the development of kidney disease-induced cardiac disease.
Title: Pre-clinical model of severe glutathione peroxidase-3 deficiency and chronic kidney disease results in coronary artery thrombosis and depressed left ventricular function.
the antioxidant enzyme GPX3 localizes to lung extracellular matrix and is variably upregulated in interstitial lung diseases.
Title: Glutathione peroxidase 3 localizes to the epithelial lining fluid and the extracellular matrix in interstitial lung disease.
These results suggest that GPx3 is an important factor for inhibition of Acetaminopheninduced hepatotoxicity both in vivo and in vitro.
Title: Glutathione peroxidase 3 is a protective factor against acetaminophen‑induced hepatotoxicity in vivo and in vitro.
GPX3 promoter methylation predicts colorectal carcinoma sensitivity to platinum.
Title: GPX3 promoter methylation predicts platinum sensitivity in colorectal cancer.
Results indicate that selenoprotein P (Sepp1) is important for this transport in selenium-replete mice but that glutathione peroxidase-3 (Gpx3) is not.
Title: Selenoprotein P is the major selenium transport protein in mouse milk.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Gpx3 (e-PCR), detects polymorphism
- UniSTS:498471

AA960521 (e-PCR)
- UniSTS:160095

NoName (e-PCR)
- UniSTS:225175

Gpx3 (e-PCR), detects polymorphism
- UniSTS:498383

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables glutathione peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione peroxidase activity	IDA Inferred from Direct Assay more info
enables glutathione peroxidase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables mercury ion binding	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables peroxidase activity	IEA Inferred from Electronic Annotation more info
enables selenium binding	IBA Inferred from Biological aspect of Ancestor more info
enables selenium binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular oxidant detoxification	IDA Inferred from Direct Assay more info
involved_in hydrogen peroxide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hydrogen peroxide catabolic process	IDA Inferred from Direct Assay more info
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glutathione peroxidase 3

Names: GPx-3; GPx-P; extracellular GPx; plasma GPx; plasma glutathione peroxidase

NP_001316789.1

EC 1.11.1.9

NP_032187.2

EC 1.11.1.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001329860.1 → NP_001316789.1 glutathione peroxidase 3 isoform 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) has an additional in-frame coding exon compared to variant 1. The resulting isoform (2) is longer, containing a 32 aa protein segment not found in isoform 1.

Source sequence(s)

AK004942, AW319411, BG796554, BY061328

UniProtKB/TrEMBL

A0A1C7ZMZ7

Related

ENSMUSP00000119882.3, ENSMUST00000149324.3
NM_008161.4 → NP_032187.2 glutathione peroxidase 3 isoform 1 precursor

See identical proteins and their annotated locations for NP_032187.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform 1.

Source sequence(s)

AK004942, BG796554, BY061328

Consensus CDS

CCDS24703.1

UniProtKB/Swiss-Prot

P46412, Q5XKR0

UniProtKB/TrEMBL

A0A1C7ZMZ5

Related

ENSMUSP00000081011.5, ENSMUST00000082430.11

Conserved Domains (1) summary

cd00340
Location:39 → 211

GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

54793680..54801213

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001083929.1: Suppressed sequence

Description

NM_001083929.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.