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SPC24 SPC24 component of NDC80 kinetochore complex [ Homo sapiens (human) ]

Gene ID: 147841, updated on 5-Mar-2024

Summary

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Official Symbol
SPC24provided by HGNC
Official Full Name
SPC24 component of NDC80 kinetochore complexprovided by HGNC
Primary source
HGNC:HGNC:26913
See related
Ensembl:ENSG00000161888 MIM:609394; AllianceGenome:HGNC:26913
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPBC24
Summary
Predicted to be involved in cell division. Located in nucleolus and nucleoplasm. Part of Ndc80 complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bone marrow (RPKM 2.7), lymph node (RPKM 1.3) and 16 other tissues See more
Orthologs
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Genomic context

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Location:
19p13.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (11145493..11155782, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (11272490..11282805, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (11256169..11266458, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:11200393-11200988 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:11200989-11201582 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:11202176-11203375 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:11205098-11206297 Neighboring gene LDLR antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:11212882-11213520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11215560-11216060 Neighboring gene low density lipoprotein receptor Neighboring gene microRNA 6886 Neighboring gene VISTA enhancer hs1754 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10101 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11276922-11277422 Neighboring gene KN motif and ankyrin repeat domains 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11300095-11300596 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11300597-11301096 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10102 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10103 Neighboring gene DOCK6 antisense RNA 1 Neighboring gene dedicator of cytokinesis 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. LINC02154 promotes the proliferation and metastasis of hepatocellular carcinoma by enhancing SPC24 promoter activity and activating the PI3K-AKT signaling pathway. Yue H, et al. Cell Oncol (Dordr), 2022 Jun. PMID 35543858
  2. SPC24 is critical for anaplastic thyroid cancer progression. Yin H, et al. Oncotarget, 2017 Mar 28. PMID 28423533, Free PMC Article
  3. A novel prognostic biomarker SPC24 up-regulated in hepatocellular carcinoma. Zhu P, et al. Oncotarget, 2015 Dec 1. PMID 26515591, Free PMC Article
  4. hsa-miR-7-5p suppresses proliferation, migration and promotes apoptosis in hepatocellular carcinoma cell lines by inhibiting SPC24 expression. Wang Y, et al. Biochem Biophys Res Commun, 2021 Jul 5. PMID 34020142
  5. SPC24 Regulates breast cancer progression by PI3K/AKT signaling. Zhou J, et al. Gene, 2018 Oct 30. PMID 30180968

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LINC02154 promotes the proliferation and metastasis of hepatocellular carcinoma by enhancing SPC24 promoter activity and activating the PI3K-AKT signaling pathway.
    Title: LINC02154 promotes the proliferation and metastasis of hepatocellular carcinoma by enhancing SPC24 promoter activity and activating the PI3K-AKT signaling pathway.
  2. hsa-miR-7-5p suppresses proliferation, migration and promotes apoptosis in hepatocellular carcinoma cell lines by inhibiting SPC24 expression.
    Title: hsa-miR-7-5p suppresses proliferation, migration and promotes apoptosis in hepatocellular carcinoma cell lines by inhibiting SPC24 expression.
  3. SPC24 is up-regulated in human breast cancer.SPC24 regulates PI3K/AKT kinase pathway in breast cancer.
    Title: SPC24 Regulates breast cancer progression by PI3K/AKT signaling.
  4. our data demonstrates that SPC24 can serve as a promising prognostic biomarker of anaplastic thyroid cancer cells
    Title: SPC24 is critical for anaplastic thyroid cancer progression.
  5. Data indicate that kinetochore protein Spc24 (SPC24) may be a promising molecular target for hepatocellular carcinoma (HCC) therapy.
    Title: A novel prognostic biomarker SPC24 up-regulated in hepatocellular carcinoma.
  6. the Spc24, Spc25, Nuf2, and Ndc80/Hec1 complex is a faithful copy of the endogenous Ndc80 complex
    Title: Architecture of the human ndc80-hec1 complex, a critical constituent of the outer kinetochore.
  7. hSPC24 is a component of the human NDC80 kinetochore complex
    Title: Identification of two novel components of the human NDC80 kinetochore complex.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome wide association study identifies common variants associated with lipid levels in the Chinese population.
EBI GWAS Catalog
Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ90806

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in attachment of spindle microtubules to kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromosome segregation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitotic spindle assembly checkpoint signaling NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of Ndc80 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Ndc80 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Ndc80 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinetochore NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
kinetochore protein Spc24
Names
SPC24, NDC80 kinetochore complex component, homolog
hSpc24
spindle pole body component 24 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317031.2 → NP_001303960.1  kinetochore protein Spc24 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC011485
    UniProtKB/TrEMBL
    K7EJV2
    Related
    ENSP00000465335.1, ENST00000592967.5
    Conserved Domains (1) summary
    pfam08286
    Location:83 → 146
    Spc24; Spc24 subunit of Ndc80

  2. NM_001317032.2 → NP_001303961.1  kinetochore protein Spc24 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC011485
    UniProtKB/TrEMBL
    K7EJH0
    Related
    ENSP00000465167.1, ENST00000585486.1
    Conserved Domains (1) summary
    pfam08286
    Location:83 → 162
    Spc24; Spc24 subunit of Ndc80

  3. NM_001394314.1 → NP_001381243.1  kinetochore protein Spc24 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC011485
    UniProtKB/TrEMBL
    K7EMX1
    Related
    ENSP00000466688.1, ENST00000591396.5
    Conserved Domains (1) summary
    COG1269
    Location:4 → 119
    NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]

  4. NM_001394315.1 → NP_001381244.1  kinetochore protein Spc24 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC011485
    UniProtKB/TrEMBL
    K7EJH0
    Conserved Domains (1) summary
    COG1269
    Location:4 → 119
    NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]

  5. NM_001394316.1 → NP_001381245.1  kinetochore protein Spc24 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC011485
    UniProtKB/TrEMBL
    K7EJH0
    Conserved Domains (1) summary
    COG1269
    Location:4 → 119
    NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]

  6. NM_001394317.1 → NP_001381246.1  kinetochore protein Spc24 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC011485
    Conserved Domains (1) summary
    COG1269
    Location:4 → 119
    NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]

  7. NM_001394318.1 → NP_001381247.1  kinetochore protein Spc24 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC011485
    Conserved Domains (1) summary
    COG1269
    Location:4 → 119
    NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]

  8. NM_182513.4 → NP_872319.1  kinetochore protein Spc24 isoform 1

    See identical proteins and their annotated locations for NP_872319.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC011485
    Consensus CDS
    CCDS45974.1
    UniProtKB/Swiss-Prot
    B4DZZ7, C9JGC4, Q8NBT2
    UniProtKB/TrEMBL
    K7EJH0
    Related
    ENSP00000465075.1, ENST00000592540.6
    Conserved Domains (2) summary
    COG1269
    Location:4 → 119
    NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]
    pfam08286
    Location:83 → 192
    Spc24; Spc24 subunit of Ndc80

RNA

  1. NR_172094.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC011485

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    11145493..11155782 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259753.4 → XP_005259810.1  kinetochore protein Spc24 isoform X1

    See identical proteins and their annotated locations for XP_005259810.1

    UniProtKB/Swiss-Prot
    Q8NBT2
    Conserved Domains (1) summary
    pfam08286
    Location:50 → 146
    Spc24; Spc24 subunit of Ndc80

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    11272490..11282805 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054319887.1 → XP_054175862.1  kinetochore protein Spc24 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NBT2.3 GenPept UniProtKB/Swiss-Prot:Q8NBT2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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