Gria2 glutamate receptor, ionotropic, AMPA2 (alpha 2) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gria2provided by MGI
Official Full Name: glutamate receptor, ionotropic, AMPA2 (alpha 2)provided by MGI
Primary source: MGI:MGI:95809
See related: Ensembl:ENSMUSG00000033981 AllianceGenome:MGI:95809
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GluA2; Glur2; GluR-B; Glur-2; gluR-K2
Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]
Expression: Biased expression in CNS E18 (RPKM 50.8), frontal lobe adult (RPKM 41.0) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 E3; 3 35.5 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (80588757..80711534, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (80681450..80804227, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The disruption of circadian rhythmicity of gene expression in the hippocampus and associated structures in Gria2[R/R] mice; a comparison with C57BL/6J and Adar2[-/-] mice strains.
Title: The disruption of circadian rhythmicity of gene expression in the hippocampus and associated structures in Gria2(R/R) mice; a comparison with C57BL/6J and Adar2(-/-) mice strains.
The Q/R editing site of AMPA receptor GluA2 subunit acts as an epigenetic switch regulating dendritic spines, neurodegeneration and cognitive deficits in Alzheimer's disease.
Title: The Q/R editing site of AMPA receptor GluA2 subunit acts as an epigenetic switch regulating dendritic spines, neurodegeneration and cognitive deficits in Alzheimer's disease.
Synaptotagmin-3 interactions with GluA2 mediate brain damage and impair functional recovery in stroke.
Title: Synaptotagmin-3 interactions with GluA2 mediate brain damage and impair functional recovery in stroke.
The M1 muscarinic acetylcholine receptor regulates the surface expression of the AMPA receptor subunit GluA2 via PICK1.
Title: The M1 muscarinic acetylcholine receptor regulates the surface expression of the AMPA receptor subunit GluA2 via PICK1.
The dorsal hippocampal protein targeting to glycogen maintains ionotropic glutamate receptor subunits expression and contributes to working and short-term memories in mice.
Title: The dorsal hippocampal protein targeting to glycogen maintains ionotropic glutamate receptor subunits expression and contributes to working and short-term memories in mice.
A circuit of mossy cells controls the efficacy of memory retrieval by Gria2I inhibition of Gria2.
Title: A circuit of mossy cells controls the efficacy of memory retrieval by Gria2I inhibition of Gria2.
Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition.
Title: Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition.
Gating and modulation of a hetero-octameric AMPA glutamate receptor.
Title: Gating and modulation of a hetero-octameric AMPA glutamate receptor.
Electroacupuncture prevents cocaine-induced conditioned place preference reinstatement and attenuates DeltaFosB and GluR2 expression.
Title: Electroacupuncture prevents cocaine-induced conditioned place preference reinstatement and attenuates ΔFosB and GluR2 expression.
AMPA receptor anchoring at CA1 synapses is determined by N-terminal domain and TARP gamma8 interactions.
Title: AMPA receptor anchoring at CA1 synapses is determined by N-terminal domain and TARP γ8 interactions.

Submit: New GeneRIF Correction See all GeneRIFs (106)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (15) 1 citation
Endonuclease-mediated (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Gria2 (e-PCR), detects polymorphism
- UniSTS:518488

Gria2 (e-PCR), detects polymorphism
- UniSTS:143252

BB085555 (e-PCR)
- UniSTS:207513

L32372 (e-PCR)
- UniSTS:124897

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables AMPA glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables AMPA glutamate receptor activity	ISO Inferred from Sequence Orthology more info
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables SNARE binding	ISO Inferred from Sequence Orthology more info
enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info
enables cytoskeletal protein binding	ISO Inferred from Sequence Orthology more info
enables extracellularly glutamate-gated ion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables glutamate receptor binding	ISO Inferred from Sequence Orthology more info
enables glutamate-gated receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables glutamate-gated receptor activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables immunoglobulin binding	ISO Inferred from Sequence Orthology more info
enables ionotropic glutamate receptor binding	ISO Inferred from Sequence Orthology more info
enables kainate selective glutamate receptor activity	ISO Inferred from Sequence Orthology more info
enables ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	ISO Inferred from Sequence Orthology more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	ISO Inferred from Sequence Orthology more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to brain-derived neurotrophic factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glycine	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in establishment of protein localization	ISO Inferred from Sequence Orthology more info
involved_in ionotropic glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in protein tetramerization	ISO Inferred from Sequence Orthology more info
involved_in receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in regulation of receptor recycling	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
involved_in synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of AMPA glutamate receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of AMPA glutamate receptor complex	IDA Inferred from Direct Assay more info	PubMed
part_of AMPA glutamate receptor complex	ISO Inferred from Sequence Orthology more info
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in asymmetric synapse	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite membrane	ISO Inferred from Sequence Orthology more info
located_in dendritic shaft	ISO Inferred from Sequence Orthology more info
is_active_in dendritic spine	IBA Inferred from Biological aspect of Ancestor more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in dendritic spine head	ISO Inferred from Sequence Orthology more info
located_in dendritic spine neck	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
located_in perisynaptic space	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in presynapse	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in somatodendritic compartment	IDA Inferred from Direct Assay more info	PubMed
located_in spine synapse	ISO Inferred from Sequence Orthology more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in synaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in terminal bouton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glutamate receptor 2

Names: AMPA selective glutamate receptor; AMPA-selective glutamate receptor 2; glutamate receptor B; glutamate receptor ionotropic, AMPA 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039195.3 → NP_001034284.2 glutamate receptor 2 isoform 3 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs at the 3' end compared to transcript variant 1, and encodes a shorter isoform (3) with a distinct C-terminus compared to isoform 1.

Source sequence(s)

AC121908, AC163349

UniProtKB/TrEMBL

C9K0Z1

Related

ENSMUST00000194383.6
NM_001083806.3 → NP_001077275.2 glutamate receptor 2 isoform 1 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform 1 (also known as the flip isoform).

Source sequence(s)

AC121908, AC163349

Consensus CDS

CCDS38459.1

UniProtKB/TrEMBL

E9QKC0, Q4LG64

Related

ENSMUSP00000103374.2, ENSMUST00000107745.8

Conserved Domains (2) summary

cd13715
Location:413 → 794

PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06389
Location:28 → 398

PBP1_iGluR_AMPA_GluR2; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor
NM_001357924.2 → NP_001344853.2 glutamate receptor 2 isoform 4 precursor

Status: REVIEWED

Source sequence(s)

AC121908, AC163349

UniProtKB/TrEMBL

Q4LG64

Conserved Domains (2) summary

cd13715
Location:413 → 794

PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06389
Location:28 → 398

PBP1_iGluR_AMPA_GluR2; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor
NM_001357927.2 → NP_001344856.2 glutamate receptor 2 isoform 5 precursor

Status: REVIEWED

Source sequence(s)

AC121908, AC163349

UniProtKB/Swiss-Prot

P23819, Q61604, Q61605, Q8BG69, Q8BXU3, Q9D6D3

Conserved Domains (2) summary

cd13715
Location:413 → 794

PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06389
Location:28 → 398

PBP1_iGluR_AMPA_GluR2; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor
NM_013540.4 → NP_038568.3 glutamate receptor 2 isoform 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate exon in the 3' coding region compared to transcript variant 1, and encodes an isoform (2, also known as the flop isoform) that is the same length as isoform 1, but with few amino acid differences.

Source sequence(s)

AC121908, AC163349

Consensus CDS

CCDS17423.1

UniProtKB/Swiss-Prot

P23819, Q61604, Q61605, Q8BG69, Q8BXU3, Q9D6D3

UniProtKB/TrEMBL

G5E8H1

Related

ENSMUSP00000074787.5, ENSMUST00000075316.10

Conserved Domains (2) summary

cd13715
Location:413 → 794

PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06389
Location:28 → 398

PBP1_iGluR_AMPA_GluR2; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor

RNA

NR_152147.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC121908, AC163349
NR_152148.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC121908, AC163349
NR_152149.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC121908, AC163349, AI841956

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

80588757..80711534 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006501014.4 → XP_006501077.1 glutamate receptor 2 isoform X1

UniProtKB/TrEMBL

C9K0Z1

Related

ENSMUSP00000141447.2, ENSMUST00000192463.2

Conserved Domains (2) summary

cd13715
Location:413 → 794

PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06389
Location:28 → 398

PBP1_iGluR_AMPA_GluR2; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor