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Gsta2 glutathione S-transferase, alpha 2 (Yc2) [ Mus musculus (house mouse) ]

Gene ID: 14858, updated on 8-Feb-2024

Summary

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Official Symbol
Gsta2provided by MGI
Official Full Name
glutathione S-transferase, alpha 2 (Yc2)provided by MGI
Primary source
MGI:MGI:95863
See related
Ensembl:ENSMUSG00000057933 AllianceGenome:MGI:95863
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gstc2; Gst2-2; Gstc-2
Summary
Predicted to enable several functions, including anion binding activity; dinitrosyl-iron complex binding activity; and glutathione peroxidase activity. Acts upstream of or within response to bacterium and response to stilbenoid. Predicted to be located in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and skeleton. Human ortholog(s) of this gene implicated in asthma and ovarian cancer. Orthologous to several human genes including GSTA5 (glutathione S-transferase alpha 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 167.8), stomach adult (RPKM 16.8) and 1 other tissue See more
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Genomic context

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Location:
9 E1; 9 43.65 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (78238300..78254474, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (78331018..78347192, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene oocyte maturation, alpha Neighboring gene oocyte maturation, beta Neighboring gene CRISPRi-validated DppDn enhancer cluster Neighboring gene CRISPRi-validated DppUp enhancer cluster Neighboring gene developmental pluripotency associated 5A Neighboring gene oocyte expressed protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Protein depletion and refeeding change the proportion of mouse liver glutathione S-transferase subunits. García-Mata R, et al. Biochim Biophys Acta, 1997 Jul 24. PMID 9268051
  2. Cloning, expression, and biochemical characterization of a functionally novel alpha class glutathione S-transferase with exceptional activity in the glutathione conjugation of (+)-anti-7,8-dihydroxy-9,10-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene. Xia H, et al. Arch Biochem Biophys, 1998 May 15. PMID 9606968
  3. Complementary DNA cloning, messenger RNA expression, and induction of alpha-class glutathione S-transferases in mouse tissues. Buetler TM, et al. Cancer Res, 1992 Jan 15. PMID 1728405
  4. Tissue-specific induction of murine glutathione transferase mRNAs by butylated hydroxyanisole. Pearson WR, et al. J Biol Chem, 1988 Sep 15. PMID 3417659
  5. Genetic mapping and systematic screening of mouse endogenously imprinted loci detected with restriction landmark genome scanning method (RLGS). Shibata H, et al. Mamm Genome, 1994 Dec. PMID 7894162

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dinitrosyl-iron complex binding ISO
Inferred from Sequence Orthology
more info
  
enables fatty acid binding ISO
Inferred from Sequence Orthology
more info
  
enables glutathione binding ISO
Inferred from Sequence Orthology
more info
  
enables glutathione peroxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutathione transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables steroid delta-isomerase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to stilbenoid IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in xenobiotic metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
glutathione S-transferase A2
Names
GST class-alpha member 2
glutathione S-transferase GT41A
NP_032208.2
XP_006510877.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008182.3 → NP_032208.2  glutathione S-transferase A2

    See identical proteins and their annotated locations for NP_032208.2

    Status: VALIDATED

    Source sequence(s)
    AC138587
    Consensus CDS
    CCDS23359.1
    UniProtKB/Swiss-Prot
    P10648, Q6P8Q1
    UniProtKB/TrEMBL
    Q8K0V9
    Related
    ENSMUSP00000034902.6, ENSMUST00000034902.12
    Conserved Domains (2) summary
    cd03208
    Location:86 → 220
    GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
    cd03077
    Location:4 → 82
    GST_N_Alpha; GST_N family, Class Alpha subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    78238300..78254474 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510814.2 → XP_006510877.1  glutathione S-transferase A2 isoform X1

    See identical proteins and their annotated locations for XP_006510877.1

    UniProtKB/Swiss-Prot
    P10648, Q6P8Q1
    UniProtKB/TrEMBL
    Q8K0V9
    Related
    ENSMUSP00000117101.2, ENSMUST00000129247.2
    Conserved Domains (2) summary
    cd03208
    Location:86 → 220
    GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
    cd03077
    Location:4 → 82
    GST_N_Alpha; GST_N family, Class Alpha subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P10648.3 GenPept UniProtKB/Swiss-Prot:P10648

Gene LinkOut

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