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Gstm4 glutathione S-transferase, mu 4 [ Mus musculus (house mouse) ]

Gene ID: 14865, updated on 3-Apr-2024

Summary

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Official Symbol
Gstm4provided by MGI
Official Full Name
glutathione S-transferase, mu 4provided by MGI
Primary source
MGI:MGI:95862
See related
Ensembl:ENSMUSG00000027890 AllianceGenome:MGI:95862
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gstb4; Gstb-4; GSTM4-4; GSTM7-7; 1110004G14Rik
Summary
Enables glutathione transferase activity. Acts upstream of or within nitrobenzene metabolic process and xenobiotic catabolic process. Predicted to be located in cytosol and intercellular bridge. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and nose. Orthologous to human GSTM4 (glutathione S-transferase mu 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 39.1), liver adult (RPKM 27.9) and 27 other tissues See more
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Genomic context

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Location:
3 F2.3; 3 46.83 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (107937887..107952495, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (108030571..108045179, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:107820964-107821073 Neighboring gene glutathione S-transferase, mu 1 Neighboring gene predicted gene 12502 Neighboring gene predicted gene, 36498 Neighboring gene predicted gene, 25592 Neighboring gene STARR-seq mESC enhancer starr_08678 Neighboring gene adenosine monophosphate deaminase 2 Neighboring gene predicted gene 12500 Neighboring gene G protein subunit alpha transducin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice. Chanas SA, et al. Biochem J, 2002 Jul 15. PMID 11991805, Free PMC Article
  2. Cloning and expression of a novel Mu class murine glutathione transferase isoenzyme. Guo J, et al. Biochem J, 2002 Sep 15. PMID 12069689, Free PMC Article
  3. The structure of two murine class-mu glutathione transferase genes coordinately induced by butylated hydroxyanisole. Reinhart J, et al. Arch Biochem Biophys, 1993 Jun. PMID 8512323
  4. Altered growth characteristics of skin fibroblasts from wild-derived mice, and genetic loci regulating fibroblast clone size. Yuan R, et al. Aging Cell, 2006 Jun. PMID 16842493
  5. Alternative mutations of a positively selected residue elicit gain or loss of functionalities in enzyme evolution. Norrgård MA, et al. Proc Natl Acad Sci U S A, 2006 Mar 28. PMID 16549767, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC40906

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables glutathione binding ISO
Inferred from Sequence Orthology
more info
  
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutathione transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables leukotriene-C4 synthase activity ISO
Inferred from Sequence Orthology
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutathione metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in long-chain fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within nitrobenzene metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within xenobiotic catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in xenobiotic catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
 PubMed 
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
glutathione S-transferase Mu 4
Names
GST class-mu 4
glutathione transferase GSTM7-7
leukotriene C4 synthase GSTM4
NP_001153883.1
NP_081040.1
XP_006501081.1
XP_006501083.1
XP_006501084.1
XP_017174951.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160411.2 → NP_001153883.1  glutathione S-transferase Mu 4 isoform 2

    See identical proteins and their annotated locations for NP_001153883.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' exon and a downstream in-frame AUG start codon, as compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, as compared to isoform 1.
    Source sequence(s)
    AL671877
    Consensus CDS
    CCDS51045.1
    UniProtKB/TrEMBL
    A2AE91
    Related
    ENSMUSP00000136643.2, ENSMUST00000178808.8
    Conserved Domains (2) summary
    cd03209
    Location:58 → 177
    GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
    cl00388
    Location:1 → 50
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

  2. NM_001428456.1 → NP_001415385.1  glutathione S-transferase Mu 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL671877
    UniProtKB/TrEMBL
    A2AE91

  3. NM_001428457.1 → NP_001415386.1  glutathione S-transferase Mu 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL671877
    UniProtKB/TrEMBL
    A2AE91

  4. NM_001428458.1 → NP_001415387.1  glutathione S-transferase Mu 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL671877
    UniProtKB/TrEMBL
    A2AE91

  5. NM_026764.4 → NP_081040.1  glutathione S-transferase Mu 4 isoform 1

    See identical proteins and their annotated locations for NP_081040.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL671877
    Consensus CDS
    CCDS17748.1
    UniProtKB/Swiss-Prot
    Q8R5I6
    Related
    ENSMUSP00000029489.9, ENSMUST00000029489.15
    Conserved Domains (2) summary
    cd03209
    Location:92 → 211
    GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
    cd03075
    Location:3 → 84
    GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    107937887..107952495 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319462.3 → XP_017174951.1  glutathione S-transferase Mu 4 isoform X2

    Conserved Domains (2) summary
    cd03075
    Location:3 → 84
    GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
    cl02776
    Location:92 → 120
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

  2. XM_006501020.4 → XP_006501083.1  glutathione S-transferase Mu 4 isoform X1

    Conserved Domains (2) summary
    cd03209
    Location:58 → 177
    GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
    cl00388
    Location:1 → 50
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

  3. XM_006501021.4 → XP_006501084.1  glutathione S-transferase Mu 4 isoform X1

    Conserved Domains (2) summary
    cd03209
    Location:58 → 177
    GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
    cl00388
    Location:1 → 50
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

  4. XM_006501018.2 → XP_006501081.1  glutathione S-transferase Mu 4 isoform X1

    Related
    ENSMUSP00000102281.2, ENSMUST00000106670.2
    Conserved Domains (2) summary
    cd03209
    Location:58 → 177
    GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
    cl00388
    Location:1 → 50
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R5I6.1 GenPept UniProtKB/Swiss-Prot:Q8R5I6

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