Hpgd hydroxyprostaglandin dehydrogenase 15 (NAD) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hpgdprovided by MGI
Official Full Name: hydroxyprostaglandin dehydrogenase 15 (NAD)provided by MGI
Primary source: MGI:MGI:108085
See related: Ensembl:ENSMUSG00000031613 AllianceGenome:MGI:108085
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 15-PGDH
Summary: Enables 15-hydroxyprostaglandin dehydrogenase (NAD+) activity. Involved in ductus arteriosus closure. Located in basolateral plasma membrane. Is expressed in several structures, including alimentary system; choroid plexus; humerus cartilage condensation; nose; and urinary system. Human ortholog(s) of this gene implicated in colon carcinoma and primary hypertrophic osteoarthropathy. Orthologous to human HPGD (15-hydroxyprostaglandin dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in lung adult (RPKM 76.0), bladder adult (RPKM 50.8) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 B2; 8 29.7 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (56747587..56774081)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (56294552..56321046)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Bile exosomal miR-182/183-5p increases cholangiocarcinoma stemness and progression by targeting HPGD and increasing PGE2 generation.
Title: Bile exosomal miR-182/183-5p increases cholangiocarcinoma stemness and progression by targeting HPGD and increasing PGE2 generation.
Inhibition of Prostaglandin-Degrading Enzyme 15-PGDH Mitigates Acute Murine Lung Allograft Rejection.
Title: Inhibition of Prostaglandin-Degrading Enzyme 15-PGDH Mitigates Acute Murine Lung Allograft Rejection.
Smad4-deficient T cells promote colitis-associated colon cancer via an IFN-gamma-dependent suppression of 15-hydroxyprostaglandin dehydrogenase.
Title: Smad4-deficient T cells promote colitis-associated colon cancer via an IFN-γ-dependent suppression of 15-hydroxyprostaglandin dehydrogenase.
Inhibition of 15-PGDH Protects Mice from Immune-Mediated Bone Marrow Failure.
Title: Inhibition of 15-PGDH Protects Mice from Immune-Mediated Bone Marrow Failure.
Early pregnancy loss in 15-hydroxyprostaglandin dehydrogenase knockout (15-HPGD(-/-)) mice due to requirement for embryo 15-HPGD activity.
Title: Early pregnancy loss in 15-hydroxyprostaglandin dehydrogenase knockout (15-HPGD(-/-)) mice due to requirement for embryo 15-HPGD activity.
Finally, ATRA replacement suppressed 15-PGDH inhibition-induced tumor progression in KC mice, and ATRA treatment attenuated Aldh1 activity in tumor cells isolated from the pancreas of 15-Pgdh(-/-) KC mice. These findings provide evidence that 15-PGDH inhibition enhances KRAS-driven tumor progression via ATRA depletion in the pancreas. Therefore, ATRA replacement could be a potential strategy for PDAC treatment.
Title: Inhibition of 15-PGDH causes Kras-driven tumor expansion through prostaglandin E2-ALDH1 signaling in the pancreas.
down-regulation of 15-hydroxy prostaglandin dehydrogenase is crucial for Prostaglandin E2-induced cervical ripening and preterm birth.
Title: Prostaglandin dehydrogenase is a target for successful induction of cervical ripening.
15-PGDH prevents lipopolysaccharide-induced acute liver injury in mice.
Title: 15-hydroxyprostaglandin dehydrogenase (15-PGDH) prevents lipopolysaccharide (LPS)-induced acute liver injury.
the protein level of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a key enzyme in prostaglandin metabolism, in Amyotrophic lateral sclerosis model mice at three different disease stages, was investigated.
Title: Increased Expression of 15-Hydroxyprostaglandin Dehydrogenase in Spinal Astrocytes During Disease Progression in a Model of Amyotrophic Lateral Sclerosis.
15-PGDH is downregulated in human hepatoma cells with a high COX-2 expression, in chemical and genetic murine models of hepatocellular carcinoma (HCC) and in human HCC biopsies.
Title: Regulation of 15-hydroxyprostaglandin dehydrogenase expression in hepatocellular carcinoma.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AV026552 (e-PCR)
- UniSTS:179749

UniSTS:498472 (e-PCR)
- UniSTS:498472

Hpgd (e-PCR), detects polymorphism
- UniSTS:498472

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 15-hydroxyicosatetraenoate dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables 15-hydroxyprostaglandin dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables 15-hydroxyprostaglandin dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables 15-hydroxyprostaglandin dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables NAD binding	ISO Inferred from Sequence Orthology more info
enables NAD+ binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	ISO Inferred from Sequence Orthology more info
enables prostaglandin E receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ductus arteriosus closure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in female pregnancy	IBA Inferred from Biological aspect of Ancestor more info
involved_in female pregnancy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in parturition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in prostaglandin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of prostaglandin catabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	ISO Inferred from Sequence Orthology more info
involved_in transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 15-hydroxyprostaglandin dehydrogenase [NAD(+)]

Names: 15-hydroxyprostaglandin dehydrogenase; PGDH; eicosanoid/docosanoid dehydrogenase; prostaglandin dehydrogenase 1

NP_032304.2

EC 1.1.1.141

EC 1.1.1.232

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.