Hras Harvey rat sarcoma virus oncogene [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hrasprovided by MGI
Official Full Name: Harvey rat sarcoma virus oncogeneprovided by MGI
Primary source: MGI:MGI:96224
See related: Ensembl:ENSMUSG00000025499 AllianceGenome:MGI:96224
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ras; H-ras; Hras1; Kras2; Ha-ras; Hras-1; c-H-ras; c-rasHa; c-Ha-ras; Harvey-ras
Summary: Enables GTP binding activity. Involved in Ras protein signal transduction. Acts upstream of or within several processes, including defense response to protozoan; intracellular signal transduction; and positive regulation of interferon-gamma production. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be active in glutamatergic synapse and plasma membrane. Is expressed in several structures, including central nervous system; early embryo; metanephros; sensory organ; and tooth. Used to study Costello syndrome; high grade glioma; and malignant astrocytoma. Human ortholog(s) of this gene implicated in several diseases, including Costello syndrome; autistic disorder; carcinoma (multiple); epidermal nevus; and large congenital melanocytic nevus. Orthologous to human HRAS (HRas proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E18 (RPKM 31.5), cortex adult (RPKM 31.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F5; 7 86.48 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (140770839..140773938, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (141189934..141194019, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Polystyrene microplastics induce anxiety via HRAS derived PERK-NF-kappaB pathway.
Title: Polystyrene microplastics induce anxiety via HRAS derived PERK-NF-κB pathway.
RAS oncogene signal strength regulates matrisomal gene expression and tumorigenicity of mouse keratinocytes.
Title: RAS oncogene signal strength regulates matrisomal gene expression and tumorigenicity of mouse keratinocytes.
The 2210408F21Rik/miR-1968-5p/Hras axis regulates synapse-related proteins in a mouse model of depressive-like behaviors through a ceRNA mechanism.
Title: The 2210408F21Rik/miR-1968-5p/Hras axis regulates synapse-related proteins in a mouse model of depressive-like behaviors through a ceRNA mechanism.
Murine models of HRAS-mediated cutaneous skeletal hypophosphatemia syndrome suggest bone as the FGF23 excess source.
Title: Murine models of HRAS-mediated cutaneous skeletal hypophosphatemia syndrome suggest bone as the FGF23 excess source.
Gain-of-Function p53N236S Mutation Drives the Bypassing of HRas[V12]-Induced Cellular Senescence via PGC-1alpha.
Title: Gain-of-Function p53N236S Mutation Drives the Bypassing of HRas(V12)-Induced Cellular Senescence via PGC-1α.
Ras drives malignancy through stem cell crosstalk with the microenvironment.
Title: Ras drives malignancy through stem cell crosstalk with the microenvironment.
Deletion of Small GTPase H-Ras Rescues Memory Deficits and Reduces Amyloid Plaque-Associated Dendritic Spine Loss in Transgenic Alzheimer's Mice.
Title: Deletion of Small GTPase H-Ras Rescues Memory Deficits and Reduces Amyloid Plaque-Associated Dendritic Spine Loss in Transgenic Alzheimer's Mice.
Redox-sensitive small GTPase H-Ras in murine astrocytes, an in vitro study.
Title: Redox-sensitive small GTPase H-Ras in murine astrocytes, an in vitro study.
MEK-inhibitor-mediated rescue of skeletal myopathy caused by activating Hras mutation in a Costello syndrome mouse model.
Title: MEK-inhibitor-mediated rescue of skeletal myopathy caused by activating Hras mutation in a Costello syndrome mouse model.
Targeting CDK4 overcomes EMT-mediated tumor heterogeneity and therapeutic resistance in KRAS-mutant lung cancer.
Title: Targeting CDK4 overcomes EMT-mediated tumor heterogeneity and therapeutic resistance in KRAS-mutant lung cancer.

Submit: New GeneRIF Correction See all GeneRIFs (174)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (11) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:177543 (e-PCR)
- UniSTS:154922

RH94696 (e-PCR)
- UniSTS:119943

PMC86690P1 (e-PCR)
- UniSTS:273544

PMC112649P1 (e-PCR)
- UniSTS:270239

PMC112649P2 (e-PCR)
- UniSTS:270240

Hras1 (e-PCR), detects polymorphism
- UniSTS:267000

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables GDP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GDP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables protein-membrane adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-membrane adaptor activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in ERBB2-ERBB3 signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in Ras protein signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Ras protein signal transduction	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within Ras protein signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in Schwann cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within T cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within T-helper 1 type immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adipose tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to gamma radiation	ISO Inferred from Sequence Orthology more info
involved_in cellular senescence	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular senescence	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular senescence	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to protozoan	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endocytosis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of fibroblast proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in insulin-like growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within intrinsic apoptotic signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within intrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myelination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of neuron apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of neuron apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within oncogene-induced cell senescence	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA replication	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of Ras protein signal transduction	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell population proliferation	IPI Inferred from Physical Interaction more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of fibroblast proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of miRNA metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phospholipase C activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein targeting to membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ruffle assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of wound healing	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within small GTPase-mediated signal transduction	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of GTPase complex	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: GTPase HRas

Names: H-Ras-1; H-ras 1 protein; Harvey rat sarcoma virus oncogene 1; c-Ha-ras p21 protein; c-Ha-ras transgene; p21ras; transforming protein P21

NP_001123915.1

EC 3.6.5.2

NP_001123916.1

EC 3.6.5.2

NP_001399407.1

EC 3.6.5.2

NP_001399408.1

EC 3.6.5.2

NP_001399409.1

EC 3.6.5.2

NP_001399410.1

EC 3.6.5.2

NP_032310.2

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130443.2 → NP_001123915.1 GTPase HRas isoform 1

See identical proteins and their annotated locations for NP_001123915.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 3' UTR, compared to variant 1, and encodes isoform 1. Variants 1 and 3-7 all encode the same isoform (1).

Source sequence(s)

AC108908

Consensus CDS

CCDS22003.1

UniProtKB/Swiss-Prot

F7BIB2, Q61411, Q6P716, Q80WD2, Q811B9

UniProtKB/TrEMBL

Q9R0B8

Related

ENSMUSP00000095570.5, ENSMUST00000097957.11

Conserved Domains (1) summary

cd04138
Location:3 → 164

H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
NM_001130444.2 → NP_001123916.1 GTPase HRas isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' UTR and includes an alternate exon in its 3' coding region, compared to variant 1. The resulting isoform (2) contains a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AC108908

Consensus CDS

CCDS52439.1

UniProtKB/TrEMBL

A0A0G2JGP4

Related

ENSMUSP00000132110.2, ENSMUST00000168550.8

Conserved Domains (2) summary

cd04138
Location:3 → 150

H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

smart00010
Location:16 → 150

small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
NM_001412478.1 → NP_001399407.1 GTPase HRas isoform 1

Status: VALIDATED

Source sequence(s)

AC108908

UniProtKB/Swiss-Prot

F7BIB2, Q61411, Q6P716, Q80WD2, Q811B9
NM_001412479.1 → NP_001399408.1 GTPase HRas isoform 1

Status: VALIDATED

Source sequence(s)

AC108908

UniProtKB/Swiss-Prot

F7BIB2, Q61411, Q6P716, Q80WD2, Q811B9
NM_001412480.1 → NP_001399409.1 GTPase HRas isoform 1

Status: VALIDATED

Source sequence(s)

AC108908

UniProtKB/Swiss-Prot

F7BIB2, Q61411, Q6P716, Q80WD2, Q811B9
NM_001412481.1 → NP_001399410.1 GTPase HRas isoform 1

Status: VALIDATED

Source sequence(s)

AC108908

UniProtKB/Swiss-Prot

F7BIB2, Q61411, Q6P716, Q80WD2, Q811B9
NM_008284.3 → NP_032310.2 GTPase HRas isoform 1

See identical proteins and their annotated locations for NP_032310.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1). Isoform 1 is also known as p21. Variants 1 and 3-7 all encode the same isoform (1).

Source sequence(s)

AC108908

Consensus CDS

CCDS22003.1

UniProtKB/Swiss-Prot

F7BIB2, Q61411, Q6P716, Q80WD2, Q811B9

UniProtKB/TrEMBL

Q9R0B8

Related

ENSMUSP00000026572.5, ENSMUST00000026572.11

Conserved Domains (1) summary

cd04138
Location:3 → 164

H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B