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Hs3st3a1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 [ Mus musculus (house mouse) ]

Gene ID: 15478, updated on 8-Feb-2024

Summary

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Official Symbol
Hs3st3a1provided by MGI
Official Full Name
heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1provided by MGI
Primary source
MGI:MGI:1333861
See related
Ensembl:ENSMUSG00000047759 AllianceGenome:MGI:1333861
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
3Ost3a; Hs3st3a
Summary
Predicted to enable [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. Predicted to be located in Golgi apparatus and membrane. Predicted to be integral component of membrane. Is expressed in several structures, including alimentary system; bone; central nervous system; genitourinary system; and respiratory system. Orthologous to human HS3ST3A1 (heparan sulfate-glucosamine 3-sulfotransferase 3A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in stomach adult (RPKM 9.7), genital fat pad adult (RPKM 7.3) and 21 other tissues See more
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Genomic context

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Location:
11 B3; 11 40.24 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (64326158..64413667)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (64435332..64522835)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29755 Neighboring gene predicted gene, 53711 Neighboring gene predicted gene, 53712 Neighboring gene STARR-seq mESC enhancer starr_29756 Neighboring gene STARR-seq mESC enhancer starr_29758 Neighboring gene RIKEN cDNA F930015N05 gene Neighboring gene STARR-seq mESC enhancer starr_29759 Neighboring gene predicted gene, 30305 Neighboring gene predicted gene 12292 Neighboring gene predicted gene, 40025

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. 3-O sulfation of syndecan-1 mediated by the sulfotransferase HS3ST3a1 enhances myeloma aggressiveness. Baert L, et al. Matrix Biol, 2023 Jun. PMID 37201729
  2. Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities. Liu J, et al. J Biol Chem, 1999 Feb 19. PMID 9988768
  3. Mutational analysis of genes with ureteric progenitor cell-specific expression in branching morphogenesis of the mouse kidney. Rutledge EA, et al. Dev Dyn, 2020 Jun. PMID 32017326, Free PMC Article
  4. FGF signaling activates a Sox9-Sox10 pathway for the formation and branching morphogenesis of mouse ocular glands. Chen Z, et al. Development, 2014 Jul. PMID 24924191, Free PMC Article
  5. Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci. Shworak NW, et al. J Biol Chem, 1999 Feb 19. PMID 9988767

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. 3-O sulfation of syndecan-1 mediated by the sulfotransferase HS3ST3a1 enhances myeloma aggressiveness.
    Title: 3-O sulfation of syndecan-1 mediated by the sulfotransferase HS3ST3a1 enhances myeloma aggressiveness.
  2. Loss of Hs3st3a1 or Hs3st3b1 enzymes alters heparan sulfate to reduce epithelial morphogenesis and adult salivary gland function.
    Title: Loss of Hs3st3a1 or Hs3st3b1 enzymes alters heparan sulfate to reduce epithelial morphogenesis and adult salivary gland function.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in branching involved in ureteric bud morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in glycosaminoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in heparan sulfate proteoglycan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
heparan sulfate glucosamine 3-O-sulfotransferase 3A1
Names
heparan sulfate 3-O-sulfotransferase 3A1
heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1
NP_849201.1
XP_030101453.1
XP_036012238.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178870.5 → NP_849201.1  heparan sulfate glucosamine 3-O-sulfotransferase 3A1

    See identical proteins and their annotated locations for NP_849201.1

    Status: VALIDATED

    Source sequence(s)
    AL646051, AL672141
    Consensus CDS
    CCDS24840.1
    UniProtKB/Swiss-Prot
    Q8BKN6
    UniProtKB/TrEMBL
    Q52KJ0
    Related
    ENSMUSP00000055930.6, ENSMUST00000058652.6
    Conserved Domains (1) summary
    pfam00685
    Location:139 → 376
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    64326158..64413667
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245593.2 → XP_030101453.1  heparan sulfate glucosamine 3-O-sulfotransferase 3A1 isoform X1

    Conserved Domains (1) summary
    cl21551
    Location:139 → 191
    Sulfotransfer_3; Sulfotransferase family

  2. XM_036156345.1 → XP_036012238.1  heparan sulfate glucosamine 3-O-sulfotransferase 3A1 isoform X2

    Conserved Domains (1) summary
    pfam00685
    Location:27 → 187
    Sulfotransfer_1; Sulfotransferase domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BKN6.1 GenPept UniProtKB/Swiss-Prot:Q8BKN6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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