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CYP2A13 cytochrome P450 family 2 subfamily A member 13 [ Homo sapiens (human) ]

Gene ID: 1553, updated on 4-Jan-2025

Summary

Official Symbol
CYP2A13provided by HGNC
Official Full Name
cytochrome P450 family 2 subfamily A member 13provided by HGNC
Primary source
HGNC:HGNC:2608
See related
Ensembl:ENSG00000197838 MIM:608055; AllianceGenome:HGNC:2608
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CPAD; CYP2A; CYPIIA13
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. Although its endogenous substrate has not been determined, it is known to metabolize 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a major nitrosamine specific to tobacco. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward liver (RPKM 9.1) See more
Orthologs
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Genomic context

See CYP2A13 in Genome Data Viewer
Location:
19q13.2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (41088451..41096195)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (43909356..43917084)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (41594356..41602100)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:41532560-41533088 Neighboring gene cytochrome P450 family 2 subfamily A member 7 pseudogene 1 Neighboring gene cytochrome P450 family 2 subfamily G member 2, pseudogene Neighboring gene cytochrome P450 family 2 subfamily F member 1 Neighboring gene uncharacterized LOC124904790 Neighboring gene cytochrome P450 family 2 subfamily T member 3, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in aflatoxin metabolic process  
involved_in coumarin metabolic process  
involved_in coumarin metabolic process  
involved_in epoxygenase P450 pathway  
involved_in xenobiotic metabolic process  
Component Evidence Code Pubs
is_active_in cytoplasm  
located_in endoplasmic reticulum membrane  
is_active_in intracellular membrane-bounded organelle  

General protein information

Preferred Names
cytochrome P450 2A13
Names
cytochrome P450, family 2, subfamily A, polypeptide 13
cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 13
NP_000757.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007928.1 RefSeqGene

    Range
    4989..12733
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000766.5NP_000757.2  cytochrome P450 2A13

    See identical proteins and their annotated locations for NP_000757.2

    Status: REVIEWED

    Source sequence(s)
    AC008962, AF209774, BM975825
    Consensus CDS
    CCDS12571.1
    UniProtKB/Swiss-Prot
    Q16696, Q53YR8, Q6R569, Q6R570, Q9H2X2
    UniProtKB/TrEMBL
    B7ZKR0
    Related
    ENSP00000332679.1, ENST00000330436.4
    Conserved Domains (1) summary
    pfam00067
    Location:34491
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    41088451..41096195
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    43909356..43917084
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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