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CYP2B6 cytochrome P450 family 2 subfamily B member 6 [ Homo sapiens (human) ]

Gene ID: 1555, updated on 4-Jan-2025

Summary

Official Symbol
CYP2B6provided by HGNC
Official Full Name
cytochrome P450 family 2 subfamily B member 6provided by HGNC
Primary source
HGNC:HGNC:2615
See related
Ensembl:ENSG00000197408 MIM:123930; AllianceGenome:HGNC:2615
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CPB6; EFVM; IIB1; P450; CYP2B; CYP2B7; CYP2B7P; CYPIIB6
Summary
This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward liver (RPKM 124.8) See more
Orthologs
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Genomic context

See CYP2B6 in Genome Data Viewer
Location:
19q13.2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (40991282..41018398)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (43812191..43839297)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (41497187..41524303)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 12493 Neighboring gene cytochrome P450 family 2 subfamily G member 1, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10651 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:41426957-41427227 Neighboring gene cytochrome P450 family 2 subfamily B member 7, pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:41486817-41487680 Neighboring gene XREM-like enhancer of CYP2B6 Neighboring gene CYP2B6 promoter-proximal regulatory region Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:41532560-41533088 Neighboring gene cytochrome P450 family 2 subfamily A member 7 pseudogene 1 Neighboring gene cytochrome P450 family 2 subfamily G member 2, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Efavirenz response
MedGen: C3281153 OMIM: 614546 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of cytochrome p450 family proteins CYP2E1, CYP2D6, and CYP2B6 in astrocytes PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in cytoplasm  
located_in endoplasmic reticulum membrane  
is_active_in intracellular membrane-bounded organelle  

General protein information

Preferred Names
cytochrome P450 2B6
Names
1,4-cineole 2-exo-monooxygenase
cytochrome P450 IIB1
cytochrome P450, family 2, subfamily B, polypeptide 6
cytochrome P450, subfamily IIB (phenobarbital-inducible), polypeptide 6
NP_000758.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007929.1 RefSeqGene

    Range
    4984..32100
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1267

mRNA and Protein(s)

  1. NM_000767.5NP_000758.1  cytochrome P450 2B6

    See identical proteins and their annotated locations for NP_000758.1

    Status: REVIEWED

    Source sequence(s)
    AC011541, AC023172, BC067431
    Consensus CDS
    CCDS12570.1
    UniProtKB/Swiss-Prot
    B4DWP3, P20813, Q2V565, Q9UK46
    UniProtKB/TrEMBL
    Q6NWU1, Q6NWU2
    Related
    ENSP00000324648.2, ENST00000324071.10
    Conserved Domains (1) summary
    pfam00067
    Location:42488
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    40991282..41018398
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    43812191..43839297
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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