Ifnb1 interferon beta 1, fibroblast [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ifnb1provided by MGI
Official Full Name: interferon beta 1, fibroblastprovided by MGI
Primary source: MGI:MGI:107657
See related: Ensembl:ENSMUSG00000048806 AllianceGenome:MGI:107657
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ifb; IFNB; If1da1; IFN-beta
Summary: Enables cytokine activity and type I interferon receptor binding activity. Involved in B cell proliferation; cellular response to virus; and type I interferon signaling pathway. Acts upstream of or within several processes, including cellular response to organic cyclic compound; defense response to other organism; and negative regulation of osteoclast differentiation. Located in extracellular space. Is expressed in embryo and liver. Human ortholog(s) of this gene implicated in COVID-19. Orthologous to human IFNB1 (interferon beta 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 4 C4; 4 41.91 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (88440253..88441083, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (88522025..88522794, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interferon-beta deficiency alters brain response to chronic HIV-1 envelope protein exposure in a transgenic model of NeuroHIV.
Title: Interferon-β deficiency alters brain response to chronic HIV-1 envelope protein exposure in a transgenic model of NeuroHIV.
Loss of TRIM24 promotes IL-10 expression via CBP/p300-dependent IFNbeta1 transcription during macrophage activation.
Title: Loss of TRIM24 promotes IL-10 expression via CBP/p300-dependent IFNβ1 transcription during macrophage activation.
Nei-like DNA glycosylase 2 selectively antagonizes interferon-beta expression upon respiratory syncytial virus infection.
Title: Nei-like DNA glycosylase 2 selectively antagonizes interferon-β expression upon respiratory syncytial virus infection.
The Cytomegalovirus M35 Protein Directly Binds to the Interferon-beta Enhancer and Modulates Transcription of Ifnb1 and Other IRF3-Driven Genes.
Title: The Cytomegalovirus M35 Protein Directly Binds to the Interferon-β Enhancer and Modulates Transcription of Ifnb1 and Other IRF3-Driven Genes.
Endoplasmic reticulum stress response and the regulation of endometrial interferon-beta production.
Title: Endoplasmic reticulum stress response and the regulation of endometrial interferon-beta production.
Interferon-beta regulates proresolving lipids to promote the resolution of acute airway inflammation.
Title: Interferon-β regulates proresolving lipids to promote the resolution of acute airway inflammation.
IFN-beta Deficiency Results in Fatal or Demyelinating Disease in C57BL/6 Mice Infected With Theiler's Murine Encephalomyelitis Viruses.
Title: IFN-β Deficiency Results in Fatal or Demyelinating Disease in C57BL/6 Mice Infected With Theiler's Murine Encephalomyelitis Viruses.
Cells Stimulated with More Than One Toll-Like Receptor-Ligand in the Presence of a MyD88 Inhibitor Augmented Interferon-beta via MyD88-Independent Signaling Pathway.
Title: Cells Stimulated with More Than One Toll-Like Receptor-Ligand in the Presence of a MyD88 Inhibitor Augmented Interferon-β via MyD88-Independent Signaling Pathway.
Induction of thymic atrophy and loss of thymic output by type-I interferons during chronic viral infection.
Title: Induction of thymic atrophy and loss of thymic output by type-I interferons during chronic viral infection.
IFN-beta rescues neurodegeneration by regulating mitochondrial fission via STAT5, PGAM5, and Drp1.
Title: IFN-β rescues neurodegeneration by regulating mitochondrial fission via STAT5, PGAM5, and Drp1.

Submit: New GeneRIF Correction See all GeneRIFs (249)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (9) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC129788P2 (e-PCR)
- UniSTS:270603

PMC103973P1 (e-PCR)
- UniSTS:270098

PMC103973P2 (e-PCR)
- UniSTS:270099

PMC99995P3 (e-PCR)
- UniSTS:273717

NoName (e-PCR)
- UniSTS:494137

Ifnb (e-PCR), detects polymorphism
- UniSTS:143460

X14455 (e-PCR)
- UniSTS:125798

PMC86305P1 (e-PCR)
- UniSTS:273522

PMC124603P1 (e-PCR)
- UniSTS:270475

PMC124610P1 (e-PCR)
- UniSTS:270476

PMC111842P1 (e-PCR)
- UniSTS:270222

PMC316809P2 (e-PCR)
- UniSTS:273049

Ifnb1 (e-PCR), detects polymorphism
- UniSTS:466089

NoName (e-PCR)
- UniSTS:489140

PMC115023P2 (e-PCR)
- UniSTS:270282

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chloramphenicol O-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IDA Inferred from Direct Assay more info	PubMed
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables cytokine receptor binding	ISO Inferred from Sequence Orthology more info
enables type I interferon receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables type I interferon receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell activation involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in B cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in B cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in B cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in T cell activation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in adaptive immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adaptive immune response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of cell surface receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to dexamethasone stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to dsRNA	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to interferon-beta	ISO Inferred from Sequence Orthology more info
involved_in cellular response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in defense response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within defense response to bacterium	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within defense response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in humoral immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within humoral immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in macrophage activation involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in natural killer cell activation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of Lewy body formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T-helper 2 cell cytokine production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of blood-brain barrier permeability	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell adhesion molecule production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of immunoglobulin production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of matrix metallopeptidase secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mononuclear cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuroinflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of osteoclast differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in neuron cellular homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peptidyl-serine phosphorylation of STAT protein	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of peptidyl-serine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transforming growth factor beta production	ISO Inferred from Sequence Orthology more info
involved_in response to exogenous dsRNA	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to exogenous dsRNA	ISO Inferred from Sequence Orthology more info	PubMed
involved_in type I interferon-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in type I interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: interferon beta

Names: interferon 1da1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010510.2 → NP_034640.1 interferon beta precursor

See identical proteins and their annotated locations for NP_034640.1

Status: VALIDATED

Source sequence(s)

AL772316

Consensus CDS

CCDS18318.1

UniProtKB/Swiss-Prot

P01575

UniProtKB/TrEMBL

Q0VE17

Related

ENSMUSP00000056720.4, ENSMUST00000055671.5

Conserved Domains (1) summary

cd00095
Location:27 → 173

IFab; Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon gamma family. Type I interferons(alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several ...