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DBI diazepam binding inhibitor, acyl-CoA binding protein [ Homo sapiens (human) ]

Gene ID: 1622, updated on 5-Mar-2024

Summary

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Official Symbol
DBIprovided by HGNC
Official Full Name
diazepam binding inhibitor, acyl-CoA binding proteinprovided by HGNC
Primary source
HGNC:HGNC:2690
See related
Ensembl:ENSG00000155368 MIM:125950; AllianceGenome:HGNC:2690
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EP; ACBP; ACBD1; CCK-RP
Summary
This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in prostate (RPKM 97.8), liver (RPKM 93.2) and 25 other tissues See more
Orthologs
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Genomic context

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See DBI in Genome Data Viewer
Location:
2q14.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (119366977..119372543)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (119800515..119806082)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (120124553..120130119)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene STEAP3 metalloreductase Neighboring gene STEAP3 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:120011987-120012930 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:120013256-120014122 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:120016992-120017765 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11902 Neighboring gene uncharacterized LOC105373581 Neighboring gene NANOG hESC enhancer GRCh37_chr2:120049626-120050127 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:120051788-120052288 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:120052289-120052789 Neighboring gene chromosome 2 open reading frame 76 Neighboring gene NANOG hESC enhancer GRCh37_chr2:120064909-120065410 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11903 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16447 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16448 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16449 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11904 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16450 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16451 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11905 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:120189865-120190371 Neighboring gene transmembrane protein 37 Neighboring gene secretin receptor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:120231245-120231796 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:120232347-120232897 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:120238515-120239026 Neighboring gene VISTA enhancer hs1941 Neighboring gene SCTR antisense RNA 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Acyl-CoA binding protein (ACBP) is highly expressed in the developing human kidney. Piras M, et al. Eur Rev Med Pharmacol Sci, 2022 May. PMID 35587082
  2. Serum DBI and biomarkers of neuroinflammation in Alzheimer's disease and delirium. Conti E, et al. Neurol Sci, 2021 Mar. PMID 32705487, Free PMC Article
  3. Phenotypic subgrouping and multi-omics analyses reveal reduced diazepam-binding inhibitor (DBI) protein levels in autism spectrum disorder with severe language impairment. Pichitpunpong C, et al. PLoS One, 2019. PMID 30921354, Free PMC Article
  4. No Relationships between Psychosis and the Diazepam Binding Inhibitor rs2276596 (C/A) Polymorphism in Japanese: An Exploratory Study. Yoshiharia E, et al. Rinsho Byori, 2016 Sep. PMID 30609452
  5. Endozepine-4 levels are increased in hepatic coma. Malaguarnera G, et al. World J Gastroenterol, 2015 Aug 14. PMID 26290636, Free PMC Article

See all (84) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Acyl coenzyme A binding protein (ACBP): An aging- and disease-relevant "autophagy checkpoint".
    Title: Acyl coenzyme A binding protein (ACBP): An aging- and disease-relevant "autophagy checkpoint".
  2. Targeting fatty acid oxidation via Acyl-CoA binding protein hinders glioblastoma invasion.
    Title: Targeting fatty acid oxidation via Acyl-CoA binding protein hinders glioblastoma invasion.
  3. Acyl-CoA binding protein (ACBP) is highly expressed in the developing human kidney.
    Title: Acyl-CoA binding protein (ACBP) is highly expressed in the developing human kidney.
  4. Serum DBI and biomarkers of neuroinflammation in Alzheimer's disease and delirium.
    Title: Serum DBI and biomarkers of neuroinflammation in Alzheimer's disease and delirium.
  5. Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity.
    Title: Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity.
  6. By subgrouping individuals with ASD based on clinical phenotypes, and then performing an integrated transcriptome-proteome analysis, we identified DBI as a novel candidate protein for ASD with severe language impairment.
    Title: Phenotypic subgrouping and multi-omics analyses reveal reduced diazepam-binding inhibitor (DBI) protein levels in autism spectrum disorder with severe language impairment.
  7. was no significant difference in the rs2276596 genotype and allele frequencies of the DBI gene between these psychoses and healthy controls
    Title: No Relationships between Psychosis and the Diazepam Binding Inhibitor rs2276596 (C/A) Polymorphism in Japanese: An Exploratory Study.
  8. ACBP increases the activity of ceramide synthase 2 (CerS2) by more than 2-fold and CerS3 activity by 7-fold. ACBP binds very-long-chain acyl-CoA esters, which is required for its ability to stimulate CerS activity.
    Title: Regulation of very-long acyl chain ceramide synthesis by acyl-CoA-binding protein.
  9. Serum endozepine-4 levels are increased in hepatic coma.
    Title: Endozepine-4 levels are increased in hepatic coma.
  10. Structural and functional properties of ACBD1, commonly known as ACBP. [Review]
    Title: Long-chain acyl-CoA esters in metabolism and signaling: Role of acyl-CoA binding proteins.
Submit: New GeneRIF Correction See all GeneRIFs (30)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC70414

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables benzodiazepine receptor binding TAS
Traceable Author Statement
more info
 PubMed 
enables fatty-acyl-CoA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables long-chain fatty acyl-CoA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of protein lipidation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidylcholine acyl-chain remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of CoA-transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of phospholipid transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
part_of protein-lipid complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
acyl-CoA-binding protein
Names
GABA receptor modulator
acyl coenzyme A binding protein
acyl-Coenzyme A binding domain containing 1
cholecystokinin-releasing peptide, trypsin-sensitive
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein)
diazepam-binding inhibitor
endozepine
epididymis secretory sperm binding protein
NP_001073331.1
NP_001073332.1
NP_001171488.1
NP_001171512.1
NP_001171513.1
NP_001171514.1
NP_001269562.1
NP_001269563.1
NP_001269564.1
NP_001269565.1
NP_001339361.1
NP_065438.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079862.4 → NP_001073331.1  acyl-CoA-binding protein isoform 3

    See identical proteins and their annotated locations for NP_001073331.1

    Status: REVIEWED

    Source sequence(s)
    AC016736
    Consensus CDS
    CCDS42740.1
    UniProtKB/Swiss-Prot
    B8ZWD2, B8ZWD6, B8ZWD7, P07108, P08869, Q4VWZ6, Q53SQ7, Q6IB48, Q9UCI8
    Related
    ENSP00000348116.3, ENST00000355857.8
    Conserved Domains (1) summary
    cd00435
    Location:2 → 86
    ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

  2. NM_001079863.3 → NP_001073332.1  acyl-CoA-binding protein isoform 2

    See identical proteins and their annotated locations for NP_001073332.1

    Status: REVIEWED

    Source sequence(s)
    AC016736
    Consensus CDS
    CCDS42741.1
    UniProtKB/Swiss-Prot
    P07108
    Related
    ENSP00000376815.2, ENST00000393103.2
    Conserved Domains (1) summary
    cd00435
    Location:5 → 87
    ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

  3. NM_001178017.3 → NP_001171488.1  acyl-CoA-binding protein isoform 4

    See identical proteins and their annotated locations for NP_001171488.1

    Status: REVIEWED

    Source sequence(s)
    AC016736
    Consensus CDS
    CCDS54391.1
    UniProtKB/Swiss-Prot
    P07108
    Related
    ENSP00000486361.1, ENST00000627305.2
    Conserved Domains (1) summary
    cd00435
    Location:74 → 147
    ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

  4. NM_001178041.4 → NP_001171512.1  acyl-CoA-binding protein isoform 5

    See identical proteins and their annotated locations for NP_001171512.1

    Status: REVIEWED

    Source sequence(s)
    AC016736
    Consensus CDS
    CCDS54390.1
    UniProtKB/Swiss-Prot
    P07108
    Related
    ENSP00000486281.1, ENST00000627093.2
    Conserved Domains (1) summary
    cd00435
    Location:55 → 128
    ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

  5. NM_001178042.4 → NP_001171513.1  acyl-CoA-binding protein isoform 1

    See identical proteins and their annotated locations for NP_001171513.1

    Status: REVIEWED

    Source sequence(s)
    AC016736
    Consensus CDS
    CCDS2126.1
    UniProtKB/TrEMBL
    A0A024RAF2
    Conserved Domains (1) summary
    cd00435
    Location:30 → 103
    ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

  6. NM_001178043.4 → NP_001171514.1  acyl-CoA-binding protein isoform 6

    See identical proteins and their annotated locations for NP_001171514.1

    Status: REVIEWED

    Source sequence(s)
    AC016736
    Consensus CDS
    CCDS74568.1
    UniProtKB/TrEMBL
    B8ZWD1
    Related
    ENSP00000442917.2, ENST00000535617.5
    Conserved Domains (1) summary
    cd00435
    Location:23 → 96
    ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

  7. NM_001282633.3 → NP_001269562.1  acyl-CoA-binding protein isoform 1

    See identical proteins and their annotated locations for NP_001269562.1

    Status: REVIEWED

    Source sequence(s)
    AC016736
    Consensus CDS
    CCDS2126.1
    UniProtKB/TrEMBL
    A0A024RAF2
    Related
    ENSP00000439012.1, ENST00000535757.5
    Conserved Domains (1) summary
    cd00435
    Location:30 → 103
    ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

  8. NM_001282634.3 → NP_001269563.1  acyl-CoA-binding protein isoform 1

    See identical proteins and their annotated locations for NP_001269563.1

    Status: REVIEWED

    Source sequence(s)
    AC016736
    Consensus CDS
    CCDS2126.1
    UniProtKB/TrEMBL
    A0A024RAF2
    Related
    ENSP00000386486.1, ENST00000409094.5
    Conserved Domains (1) summary
    cd00435
    Location:30 → 103
    ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

  9. NM_001282635.3 → NP_001269564.1  acyl-CoA-binding protein isoform 1

    See identical proteins and their annotated locations for NP_001269564.1

    Status: REVIEWED

    Source sequence(s)
    AC016736
    Consensus CDS
    CCDS2126.1
    UniProtKB/TrEMBL
    A0A024RAF2
    Related
    ENSP00000311117.4, ENST00000311521.8
    Conserved Domains (1) summary
    cd00435
    Location:30 → 103
    ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

  10. NM_001282636.3 → NP_001269565.1  acyl-CoA-binding protein isoform 7

    See identical proteins and their annotated locations for NP_001269565.1

    Status: REVIEWED

    Source sequence(s)
    AC016736
    UniProtKB/TrEMBL
    B8ZWD8
    Conserved Domains (1) summary
    cl00221
    Location:1 → 62
    ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

  11. NM_001352432.3 → NP_001339361.1  acyl-CoA-binding protein isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC016736
    UniProtKB/TrEMBL
    B8ZWD8
    Related
    ENST00000460901.1
    Conserved Domains (1) summary
    cl00221
    Location:1 → 62
    ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

  12. NM_020548.9 → NP_065438.1  acyl-CoA-binding protein isoform 1

    See identical proteins and their annotated locations for NP_065438.1

    Status: REVIEWED

    Source sequence(s)
    AC016736
    Consensus CDS
    CCDS2126.1
    UniProtKB/TrEMBL
    A0A024RAF2
    Conserved Domains (1) summary
    cd00435
    Location:30 → 103
    ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    119366977..119372543
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    119800515..119806082
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P07108.2 GenPept UniProtKB/Swiss-Prot:P07108

Gene LinkOut

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