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Mlxipl MLX interacting protein-like [ Rattus norvegicus (Norway rat) ]

Gene ID: 171078, updated on 4-Jan-2025

Summary

Official Symbol
Mlxiplprovided by RGD
Official Full Name
MLX interacting protein-likeprovided by RGD
Primary source
RGD:620400
See related
EnsemblRapid:ENSRNOG00000046171 AllianceGenome:RGD:620400
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ChREBP; WS-bHLH; Wbscr14; bHLHd14
Summary
Enables DNA-binding transcription factor activity; protein kinase binding activity; and sequence-specific DNA binding activity. Involved in several processes, including cellular response to glucose stimulus; fatty acid homeostasis; and regulation of nucleobase-containing compound metabolic process. Located in cytosol and nucleus. Biomarker of end stage renal disease; kidney disease; metabolic dysfunction-associated steatohepatitis; metabolic dysfunction-associated steatotic liver disease; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in coronary artery disease and myocardial infarction. Orthologous to human MLXIPL (MLX interacting protein like). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Liver (RPKM 178.9), Adrenal (RPKM 142.5) and 6 other tissues See more
Orthologs
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Genomic context

See Mlxipl in Genome Data Viewer
Location:
12q12
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (27178158..27213675, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (21541608..21577120, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (24590645..24619639, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene BAF chromatin remodeling complex subunit BCL7B Neighboring gene transducin (beta)-like 2 Neighboring gene VPS37D subunit of ESCRT-I Neighboring gene DnaJ heat shock protein family (Hsp40) member C30

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding PubMed 
contributes_to DNA binding  
enables DNA-binding transcription activator activity  
enables DNA-binding transcription activator activity, RNA polymerase II-specific  
enables DNA-binding transcription activator activity, RNA polymerase II-specific  
enables DNA-binding transcription factor activity PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific  
enables DNA-binding transcription factor activity, RNA polymerase II-specific  
enables DNA-binding transcription factor binding  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
enables RNA polymerase II-specific DNA-binding transcription factor binding  
enables RNA polymerase II-specific DNA-binding transcription factor binding  
enables carbohydrate response element binding PubMed 
enables protein binding PubMed 
enables protein dimerization activity  
enables protein heterodimerization activity  
enables protein heterodimerization activity  
NOT enables protein homodimerization activity  
enables protein kinase binding PubMed 
enables sequence-specific DNA binding PubMed 
Items 1 - 25 of 32
Process Evidence Code Pubs
involved_in cellular response to glucose stimulus PubMed 
involved_in energy homeostasis PubMed 
involved_in fatty acid homeostasis PubMed 
involved_in glucose homeostasis  
involved_in glucose mediated signaling pathway  
involved_in glucose mediated signaling pathway  
involved_in lipid biosynthetic process  
involved_in lipid biosynthetic process  
involved_in negative regulation of DNA-templated transcription  
involved_in negative regulation of oxidative phosphorylation  
involved_in negative regulation of oxidative phosphorylation  
involved_in negative regulation of peptidyl-serine phosphorylation  
involved_in negative regulation of transcription by RNA polymerase II  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II  
involved_in positive regulation of DNA-templated transcription  
involved_in positive regulation of cell population proliferation  
involved_in positive regulation of cell population proliferation  
involved_in positive regulation of fatty acid biosynthetic process  
involved_in positive regulation of fatty acid biosynthetic process  
involved_in positive regulation of glycolytic process  
involved_in positive regulation of glycolytic process  
involved_in positive regulation of lipid biosynthetic process  
involved_in positive regulation of transcription by RNA polymerase II  
involved_in positive regulation of transcription from RNA polymerase II promoter by glucose  
involved_in positive regulation of transcription from RNA polymerase II promoter by glucose  
involved_in regulation of glycolytic process PubMed 
involved_in regulation of transcription by RNA polymerase II  
involved_in regulation of transcription by RNA polymerase II PubMed 
involved_in response to glucose PubMed 
involved_in response to nutrient PubMed 
involved_in response to nutrient levels PubMed 
involved_in response to vitamin B3 PubMed 
Items 1 - 25 of 32
Component Evidence Code Pubs
located_in chromatin  
is_active_in chromatin  
located_in cytoplasm  
located_in cytosol PubMed 
located_in cytosol  
located_in cytosol  
located_in cytosol  
located_in nucleoplasm  
is_active_in nucleoplasm  
located_in nucleoplasm  
located_in nucleoplasm  
is_active_in nucleus  
located_in nucleus PubMed 
located_in nucleus  
is_active_in nucleus  
located_in nucleus  
part_of transcription regulator complex  
part_of transcription regulator complex  

General protein information

Preferred Names
carbohydrate-responsive element-binding protein
Names
MLX interactor
WS basic-helix-loop-helix leucine zipper protein
Williams-Beuren syndrome chromosomal region 14 protein
Williams-Beuren syndrome chromosome region 14 homolog
class D basic helix-loop-helix protein 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001393706.1NP_001380635.1  carbohydrate-responsive element-binding protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A0A8I6ADP9, C7C5T1
    Related
    ENSRNOP00000090385.1, ENSRNOT00000074230.5
    Conserved Domains (2) summary
    PHA03247
    Location:262656
    PHA03247; large tegument protein UL36; Provisional
    cd19689
    Location:660735
    bHLHzip_MLXIPL; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein-like (MLXIPL) and similar proteins
  2. NM_133552.2NP_598236.2  carbohydrate-responsive element-binding protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/Swiss-Prot
    Q8VIP2
    UniProtKB/TrEMBL
    A6J0E8
    Related
    ENSRNOP00000093059.2, ENSRNOT00000071067.4
    Conserved Domains (2) summary
    PHA03247
    Location:262655
    PHA03247; large tegument protein UL36; Provisional
    cd19689
    Location:659734
    bHLHzip_MLXIPL; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein-like (MLXIPL) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    27178158..27213675 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089043.2XP_038944971.1  carbohydrate-responsive element-binding protein isoform X1

    Conserved Domains (2) summary
    PHA03247
    Location:85479
    PHA03247; large tegument protein UL36; Provisional
    cd19689
    Location:483558
    bHLHzip_MLXIPL; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein-like (MLXIPL) and similar proteins
  2. XM_063271027.1XP_063127097.1  carbohydrate-responsive element-binding protein isoform X3

  3. XM_039089044.2XP_038944972.2  carbohydrate-responsive element-binding protein isoform X2

  4. XM_063271028.1XP_063127098.1  carbohydrate-responsive element-binding protein isoform X4

RNA

  1. XR_005491594.2 RNA Sequence

  2. XR_005491593.2 RNA Sequence

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