Slc26a6 solute carrier family 26, member 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc26a6provided by MGI
Official Full Name: solute carrier family 26, member 6provided by MGI
Primary source: MGI:MGI:2159728
See related: Ensembl:ENSMUSG00000023259 AllianceGenome:MGI:2159728
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CFEX; Pat1; Pat-1; B930010B04Rik
Summary: Enables PDZ domain binding activity and anion transmembrane transporter activity. Involved in several processes, including anion transport; cellular response to cAMP; and cellular response to fructose stimulus. Located in several cellular components, including apical plasma membrane; brush border membrane; and sperm midpiece. Is integral component of plasma membrane. Orthologous to human SLC26A6 (solute carrier family 26 member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in duodenum adult (RPKM 132.0), small intestine adult (RPKM 106.4) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F2; 9 59.63 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (108731239..108742117)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (108854043..108913049)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A mathematical model of ENaC and Slc26a6 regulation by CFTR in salivary gland ducts.
Title: A mathematical model of ENaC and Slc26a6 regulation by CFTR in salivary gland ducts.
Ablation of TRPC3 compromises bicarbonate and phosphate transporter activity in mice proximal tubular cells.
Title: Ablation of TRPC3 compromises bicarbonate and phosphate transporter activity in mice proximal tubular cells.
A patatin-like phospholipase mediates Rickettsia parkeri escape from host membranes.
Title: A patatin-like phospholipase mediates Rickettsia parkeri escape from host membranes.
The anion exchanger PAT-1 (Slc26a6) does not participate in oxalate or chloride transport by mouse large intestine.
Title: The anion exchanger PAT-1 (Slc26a6) does not participate in oxalate or chloride transport by mouse large intestine.
Enteric Oxalate Secretion Mediated by Slc26a6 Defends against Hyperoxalemia in Murine Models of Chronic Kidney Disease.
Title: Enteric Oxalate Secretion Mediated by Slc26a6 Defends against Hyperoxalemia in Murine Models of Chronic Kidney Disease.
Induction of enteric oxalate secretion by Oxalobacter formigenes in mice does not require the presence of either apical oxalate transport proteins Slc26A3 or Slc26A6.
Title: Induction of enteric oxalate secretion by Oxalobacter formigenes in mice does not require the presence of either apical oxalate transport proteins Slc26A3 or Slc26A6.
Slc26a6 is an apical membrane anion exchanger that drives HCO3(-)-dependent fluid secretion in murine pancreatic acinar cells.
Title: Slc26a6 is an apical membrane anion exchanger that drives HCO(3)(-)-dependent fluid secretion in murine pancreatic acinar cells.
these data suggest that PAT1 is a new actor in transferrin early endocytosis. Whether this new function of PAT1 may have consequences in pathology remains to be determined.
Title: Protein interacting with Amyloid Precursor Protein tail-1 (PAT1) is involved in early endocytosis.
SLC26A6 is dispensable for renal NaCl homeostasis, but it is required for net renal secretion of oxalate.
Title: Characterization of renal NaCl and oxalate transport in Slc26a6(-/-) mice.
findings indicate that Slc26a6 is located at the apical membrane of salivary gland acinar cells, where it mediates Cl(-)/oxalate exchange and plays a critical role in the secretion of oxalate into saliva.
Title: The apical anion exchanger Slc26a6 promotes oxalate secretion by murine submandibular gland acinar cells.

Submit: New GeneRIF Correction See all GeneRIFs (42)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables PDZ domain binding	IDA Inferred from Direct Assay more info	PubMed
enables antiporter activity	IEA Inferred from Electronic Annotation more info
enables bicarbonate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables bicarbonate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables bicarbonate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables chloride channel activity	IEA Inferred from Electronic Annotation more info
enables chloride transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables chloride transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables chloride transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables chloride transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables chloride:bicarbonate antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables chloride:bicarbonate antiporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables chloride:bicarbonate antiporter activity	ISO Inferred from Sequence Orthology more info
enables efflux transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables formate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables oxalate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxalate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables oxalate transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables secondary active sulfate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables solute:inorganic anion antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables solute:inorganic anion antiporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables solute:inorganic anion antiporter activity	ISO Inferred from Sequence Orthology more info
enables sulfate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sulfate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables sulfate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables sulfate:bicarbonate antiporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in angiotensin-activated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within bicarbonate transport	IDA Inferred from Direct Assay more info	PubMed
involved_in bicarbonate transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within bicarbonate transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in bicarbonate transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in bicarbonate transport	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cAMP	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to fructose stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to type II interferon	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chloride transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within chloride transport	IDA Inferred from Direct Assay more info	PubMed
involved_in chloride transport	IDA Inferred from Direct Assay more info	PubMed
involved_in chloride transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chloride transport	ISO Inferred from Sequence Orthology more info
involved_in epithelial fluid transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within formate transport	IDA Inferred from Direct Assay more info	PubMed
involved_in formate transport	IDA Inferred from Direct Assay more info	PubMed
involved_in formate transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intestinal absorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular pH elevation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mannitol transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in oxalate transport	IDA Inferred from Direct Assay more info	PubMed
involved_in oxalate transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oxalate transport	ISO Inferred from Sequence Orthology more info
involved_in oxalic acid secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of dipeptide transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein kinase C signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in protein kinase C signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of intracellular pH	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of intracellular pH	ISO Inferred from Sequence Orthology more info
involved_in sperm capacitation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sulfate transport	IDA Inferred from Direct Assay more info	PubMed
involved_in sulfate transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sulfate transport	ISO Inferred from Sequence Orthology more info
involved_in transepithelial chloride transport	IDA Inferred from Direct Assay more info	PubMed
involved_in transepithelial chloride transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transepithelial chloride transport	ISO Inferred from Sequence Orthology more info
involved_in transepithelial transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	IDA Inferred from Direct Assay more info	PubMed
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
part_of chloride channel complex	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in sperm midpiece	IDA Inferred from Direct Assay more info	PubMed
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in vesicle membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: solute carrier family 26 member 6

Names: anion exchange transporter; chloride-formate exchanger; pendrin-L1; pendrin-like protein 1; putative anion transporter-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001408387.1 → NP_001395316.1 solute carrier family 26 member 6 isoform 2

Status: VALIDATED

Source sequence(s)

AC168054, AEKQ02060806

UniProtKB/Swiss-Prot

E9Q4D3, Q3TQD3, Q812E2, Q8CIW6, Q8CJD0, Q8K142, Q923J3

Related

ENSMUSP00000140849.3, ENSMUST00000188557.8
NM_134420.5 → NP_599252.2 solute carrier family 26 member 6 isoform 1

See identical proteins and their annotated locations for NP_599252.2

Status: VALIDATED

Source sequence(s)

AC168054, AEKQ02060806

UniProtKB/TrEMBL

A0A087WS07

Related

ENSMUSP00000159445.2, ENSMUST00000239562.1

Conserved Domains (1) summary

TIGR00815
Location:55 → 714

sulP; high affinity sulphate transporter 1

RNA

NR_176680.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC168054, AEKQ02060806

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

108731239..108742117

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036154634.1 → XP_036010527.1 solute carrier family 26 member 6 isoform X2

UniProtKB/TrEMBL

A0A087WS07

Conserved Domains (1) summary

TIGR00815
Location:55 → 714

sulP; high affinity sulphate transporter 1