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Mertk MER proto-oncogene tyrosine kinase [ Mus musculus (house mouse) ]

Gene ID: 17289, updated on 12-May-2024

Summary

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Official Symbol
Mertkprovided by MGI
Official Full Name
MER proto-oncogene tyrosine kinaseprovided by MGI
Primary source
MGI:MGI:96965
See related
Ensembl:ENSMUSG00000014361 AllianceGenome:MGI:96965
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Eyk; Mer; Nyk; nmf12
Summary
Predicted to enable transmembrane receptor protein tyrosine kinase activity. Acts upstream of or within several processes, including animal organ development; neutrophil clearance; and protein kinase B signaling. Predicted to be located in several cellular components, including extracellular space; photoreceptor outer segment; and rhabdomere. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; immune system; and retina. Human ortholog(s) of this gene implicated in retinitis pigmentosa 38. Orthologous to human MERTK (MER proto-oncogene, tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 4.8), kidney adult (RPKM 4.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mertk in Genome Data Viewer
Location:
2 F1; 2 62.63 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (128540836..128645082)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (128698915..128803162)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene protein transport protein Sec61 subunit gamma pseudogene Neighboring gene anaphase promoting complex subunit 1 Neighboring gene STARR-positive B cell enhancer ABC_E4498 Neighboring gene predicted gene, 39931 Neighboring gene VISTA enhancer mm1476 Neighboring gene STARR-seq mESC enhancer starr_05650 Neighboring gene STARR-seq mESC enhancer starr_05651 Neighboring gene STARR-positive B cell enhancer ABC_E2046 Neighboring gene transmembrane protein 87B Neighboring gene fibulin 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Activation of regulatory dendritic cells by Mertk coincides with a temporal wave of apoptosis in neonatal lungs. Silva-Sanchez A, et al. Sci Immunol, 2023 Jun 23. PMID 37327322, Free PMC Article
  2. Absence of MerTK disrupts spermatogenesis in an age-dependent manner. Shi J, et al. Mol Cell Endocrinol, 2023 Jan 15. PMID 36379275
  3. Pentoxifylline alleviates ischemic white matter injury through up-regulating Mertk-mediated myelin clearance. Zheng L, et al. J Neuroinflammation, 2022 May 31. PMID 35642056, Free PMC Article
  4. Defective Efferocytosis in a Murine Model of Sjögren's Syndrome Is Mediated by Dysfunctional Mer Tyrosine Kinase Receptor. Witas R, et al. Int J Mol Sci, 2021 Sep 8. PMID 34575873, Free PMC Article
  5. Microglial MERTK eliminates phosphatidylserine-displaying inhibitory post-synapses. Park J, et al. EMBO J, 2021 Aug 2. PMID 34013588, Free PMC Article

See all (230) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibition of MERTK reduces organ fibrosis in mouse models of fibrotic disease.
    Title: Inhibition of MERTK reduces organ fibrosis in mouse models of fibrotic disease.
  2. Disruption of MerTK increases the efficacy of checkpoint inhibitor by enhancing ferroptosis and immune response in hepatocellular carcinoma.
    Title: Disruption of MerTK increases the efficacy of checkpoint inhibitor by enhancing ferroptosis and immune response in hepatocellular carcinoma.
  3. Trained immunity of alveolar macrophages enhances injury resolution via KLF4-MERTK-mediated efferocytosis.
    Title: Trained immunity of alveolar macrophages enhances injury resolution via KLF4-MERTK-mediated efferocytosis.
  4. Elevated expression of macrophage MERTK exhibits profibrotic effects and results in defective regulation of efferocytosis function in pulmonary fibrosis.
    Title: Elevated expression of macrophage MERTK exhibits profibrotic effects and results in defective regulation of efferocytosis function in pulmonary fibrosis.
  5. Receptor tyrosine kinases Tyro3, Axl, and Mertk differentially contribute to antibody-induced arthritis.
    Title: Receptor tyrosine kinases Tyro3, Axl, and Mertk differentially contribute to antibody-induced arthritis.
  6. Activation of regulatory dendritic cells by Mertk coincides with a temporal wave of apoptosis in neonatal lungs.
    Title: Activation of regulatory dendritic cells by Mertk coincides with a temporal wave of apoptosis in neonatal lungs.
  7. Gsk3beta regulates the resolution of liver ischemia/reperfusion injury via MerTK.
    Title: Gsk3β regulates the resolution of liver ischemia/reperfusion injury via MerTK.
  8. Absence of MerTK disrupts spermatogenesis in an age-dependent manner.
    Title: Absence of MerTK disrupts spermatogenesis in an age-dependent manner.
  9. Early death in a mouse model of Alzheimer's disease exacerbated by microglial loss of TAM receptor signaling.
    Title: Early death in a mouse model of Alzheimer's disease exacerbated by microglial loss of TAM receptor signaling.
  10. Regulation of bone homeostasis by MERTK and TYRO3.
    Title: Regulation of bone homeostasis by MERTK and TYRO3.
Submit: New GeneRIF Correction See all GeneRIFs (124)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic cell clearance IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within apoptotic cell clearance IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within apoptotic cell clearance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in apoptotic cell clearance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of lymphocyte activation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within natural killer cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of cytokine production IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of leukocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of lymphocyte activation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neutrophil clearance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in phagocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phagocytosis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within platelet activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within retina development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within secretion by cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spermatogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within vagina development IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in photoreceptor outer segment ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tyrosine-protein kinase Mer
Names
Tyro 12
c-mer proto-oncogene tyrosine kinase
proto-oncogene c-Mer
proto-oncogene tyrosine-protein kinase Mer
receptor tyrosine kinase MerTK
NP_001407342.1
NP_001407343.1
NP_032613.1
XP_036014911.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001420413.1 → NP_001407342.1  tyrosine-protein kinase Mer isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL808104, AL928910

  2. NM_001420414.1 → NP_001407343.1  tyrosine-protein kinase Mer isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL808104, AL928910

  3. NM_008587.3 → NP_032613.1  tyrosine-protein kinase Mer isoform 2 precursor

    See identical proteins and their annotated locations for NP_032613.1

    Status: VALIDATED

    Source sequence(s)
    AL808104, AL928910
    Consensus CDS
    CCDS16716.1
    UniProtKB/Swiss-Prot
    Q60805, Q62194
    Related
    ENSMUSP00000014505.5, ENSMUST00000014505.5
    Conserved Domains (6) summary
    cd05749
    Location:194 → 274
    Ig2_Tyro3_like; Second immunoglobulin (Ig)-like domain of Axl/Tyro3 receptor tyrosine kinases (RTKs)
    smart00410
    Location:198 → 275
    IG_like; Immunoglobulin like
    cd00063
    Location:279 → 373
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14204
    Location:574 → 857
    PTKc_Mer; Catalytic Domain of the Protein Tyrosine Kinase, Mer
    pfam00047
    Location:97 → 177
    ig; Immunoglobulin domain
    pfam07714
    Location:582 → 849
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    128540836..128645082
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159018.1 → XP_036014911.1  tyrosine-protein kinase Mer isoform X2

    UniProtKB/TrEMBL
    Q8CE52
    Conserved Domains (1) summary
    cd14204
    Location:78 → 361
    PTKc_Mer; Catalytic Domain of the Protein Tyrosine Kinase, Mer
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60805.1 GenPept UniProtKB/Swiss-Prot:Q60805

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