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uba-1 Ubiquitin-activating enzyme E1 C-terminal domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177855, updated on 23-Nov-2023

Summary

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Gene symbol
uba-1
Gene description
Ubiquitin-activating enzyme E1 C-terminal domain-containing protein
Primary source
WormBase:WBGene00006699
Locus tag
CELE_C47E12.5
See related
AllianceGenome:WB:WBGene00006699
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ubiquitin activating enzyme activity. Involved in several processes, including cellular protein metabolic process; gamete generation; and nematode male tail tip morphogenesis. Located in nucleus. Is expressed in several structures, including anterior hypodermis; germ line; head muscle; midbody; and neurons. Human ortholog(s) of this gene implicated in VEXAS syndrome and X-linked spinal muscular atrophy 2. Orthologous to several human genes including UBA1 (ubiquitin like modifier activating enzyme 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
7
Sequence:
Chromosome: IV; NC_003282.8 (9989673..9994945, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene MAM domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Inorganic pyrophosphatase 1 Neighboring gene alpha-1,2-Mannosidase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A catechin-enriched green tea extract prevents glucose-induced survival reduction in Caenorhabditis elegans through sir-2.1 and uba-1 dependent hormesis. Deusing DJ, et al. Fitoterapia, 2015 Apr. PMID 25771124
  2. Transcription reactivation steps stimulated by oocyte maturation in C. elegans. Walker AK, et al. Dev Biol, 2007 Apr 1. PMID 17291483, Free PMC Article
  3. E1 ubiquitin-activating enzyme UBA-1 plays multiple roles throughout C. elegans development. Kulkarni M, et al. PLoS Genet, 2008 Jul 18. PMID 18636104, Free PMC Article
  4. Regulation of mechanosensation in C. elegans through ubiquitination of the MEC-4 mechanotransduction channel. Chen X, et al. J Neurosci, 2015 Feb 4. PMID 25653375, Free PMC Article
  5. Mutual antagonism between the anaphase promoting complex and the spindle assembly checkpoint contributes to mitotic timing in Caenorhabditis elegans. Bezler A, et al. Genetics, 2010 Dec. PMID 20944014, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. uba-1 plays multiple roles throughout C. elegans development.
    Title: E1 ubiquitin-activating enzyme UBA-1 plays multiple roles throughout C. elegans development.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin activating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-like modifier activating enzyme activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nematode larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nematode male tail tip morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuromuscular process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in programmed cell death involved in cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein modification by small protein conjugation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein modification process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Ubiquitin-activating enzyme E1 C-terminal domain-containing protein
NP_001033404.1
  • Confirmed by transcript evidence
NP_001367213.1
  • Confirmed by transcript evidence
NP_001379450.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    9989673..9994945 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001038315.9 → NP_001033404.1  Ubiquitin-activating enzyme E1 C-terminal domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001033404.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q27481
    Conserved Domains (1) summary
    TIGR01408
    Location:103 → 1111
    Ube1; ubiquitin-activating enzyme E1

  2. NM_001392377.1 → NP_001379450.1  Ubiquitin-activating enzyme E1 C-terminal domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q3S1J5
    Conserved Domains (1) summary
    TIGR01408
    Location:18 → 1026
    Ube1; ubiquitin-activating enzyme E1

  3. NM_001380424.1 → NP_001367213.1  Ubiquitin-activating enzyme E1 C-terminal domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    C1P636
    Conserved Domains (1) summary
    TIGR01408
    Location:102 → 1110
    Ube1; ubiquitin-activating enzyme E1
Nucleotide Protein
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