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cpsf-4 Cleavage and polyadenylation specificity factor subunit 4 [ Caenorhabditis elegans ]

Gene ID: 178151, updated on 7-Sep-2023

Summary

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Gene symbol
cpsf-4
Gene description
Cleavage and polyadenylation specificity factor subunit 4
Primary source
WormBase:WBGene00044329
Locus tag
CELE_F11A10.8
See related
AllianceGenome:WB:WBGene00044329
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable nucleic acid binding activity and zinc ion binding activity. Predicted to be involved in pre-mRNA cleavage required for polyadenylation. Predicted to be located in nucleus. Orthologous to several human genes including CPSF4 (cleavage and polyadenylation specific factor 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
3
Sequence:
Chromosome: IV; NC_003282.8 (12092322..12093445, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene RRM domain-containing protein Neighboring gene Transmembrane protein 115 Neighboring gene Polycomb group RING finger protein 3 homolog mig-32 Neighboring gene Protein ST7 homolog Neighboring gene Monensin-resistant homolog 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Spatiotemporal m(i)RNA Architecture and 3' UTR Regulation in the C. elegans Germline. Diag A, et al. Dev Cell, 2018 Dec 17. PMID 30416012
  2. Casein Kinase 1δ Stabilizes Mature Axons by Inhibiting Transcription Termination of Ankyrin. LaBella ML, et al. Dev Cell, 2020 Jan 6. PMID 31910362, Free PMC Article
  3. Genes involved in pre-mRNA 3'-end formation and transcription termination revealed by a lin-15 operon Muv suppressor screen. Cui M, et al. Proc Natl Acad Sci U S A, 2008 Oct 28. PMID 18946043, Free PMC Article
  4. The Regulatory Landscape of Lineage Differentiation in a Metazoan Embryo. Du Z, et al. Dev Cell, 2015 Sep 14. PMID 26321128, Free PMC Article
  5. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables enzyme binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Cleavage and polyadenylation specificity factor subunit 4
NP_001023126.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    12092322..12093445 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027955.4 → NP_001023126.1  Cleavage and polyadenylation specificity factor subunit 4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023126.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7YTG9
    Conserved Domains (2) summary
    smart00356
    Location:77 → 102
    ZnF_C3H1; zinc finger
    COG5084
    Location:66 → 187
    YTH1; Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins [General function prediction only]
Nucleotide Protein
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