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egl-3 Neuroendocrine convertase 2 [ Caenorhabditis elegans ]

Gene ID: 179412, updated on 23-Jan-2025

Summary

Official Symbol
egl-3
Official Full Name
Neuroendocrine convertase 2
Primary source
WormBase:WBGene00001172
Locus tag
CELE_C51E3.7
See related
AllianceGenome:WB:WBGene00001172
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables FBXO family protein binding activity and serine-type endopeptidase activity. Involved in several processes, including modulation of chemical synaptic transmission; positive regulation of behavior; and protein processing. Located in axon. Is expressed in several structures, including intestine; nervous system; pharynx; tail; and uv1. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in myocardial infarction and type 2 diabetes mellitus. Orthologous to human PCSK2 (proprotein convertase subtilisin/kexin type 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See egl-3 in Genome Data Viewer
Location:
chromosome: V
Exon count:
8
Sequence:
Chromosome: V; NC_003283.11 (10169177..10173753, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene DUF3149 domain-containing protein Neighboring gene Solute carrier family 23 member 2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables FBXO family protein binding PubMed 
enables serine-type endopeptidase activity  
enables serine-type endopeptidase activity  
enables serine-type endopeptidase activity PubMed 
enables serine-type peptidase activity  
Items 1 - 25 of 33
Process Evidence Code Pubs
involved_in arg-arg specific dibasic protein processing PubMed 
involved_in determination of adult lifespan PubMed 
involved_in dibasic protein processing PubMed 
involved_in insulin processing PubMed 
involved_in larval feeding behavior PubMed 
involved_in negative regulation of dauer entry PubMed 
involved_in negative regulation of dense core granule transport PubMed 
involved_in negative regulation of turning behavior involved in mating PubMed 
involved_in neuromuscular synaptic transmission PubMed 
involved_in neuropeptide processing PubMed 
involved_in peptide hormone processing  
involved_in positive regulation of acetylcholine secretion, neurotransmission PubMed 
involved_in positive regulation of acetylcholine secretion, neurotransmission PubMed 
involved_in positive regulation of backward locomotion PubMed 
involved_in positive regulation of digestive system process PubMed 
involved_in positive regulation of egg-laying behavior PubMed 
involved_in positive regulation of forward locomotion PubMed 
involved_in positive regulation of forward locomotion PubMed 
involved_in positive regulation of lipid localization PubMed 
involved_in positive regulation of locomotion involved in locomotory behavior PubMed 
involved_in positive regulation of synaptic assembly at neuromuscular junction PubMed 
involved_in proteolysis  
involved_in regulation of backward locomotion PubMed 
involved_in regulation of eating behavior PubMed 
involved_in regulation of locomotion involved in locomotory behavior PubMed 
involved_in regulation of locomotion involved in locomotory behavior PubMed 
involved_in regulation of muscle contraction PubMed 
involved_in regulation of muscle contraction PubMed 
involved_in regulation of neuromuscular synaptic transmission PubMed 
involved_in regulation of synaptic assembly at neuromuscular junction PubMed 
involved_in response to mechanical stimulus PubMed 
involved_in response to mechanical stimulus PubMed 
involved_in response to serotonin PubMed 
Items 1 - 25 of 33
Component Evidence Code Pubs
located_in axon PubMed 
located_in axon  
located_in cell projection  
located_in cytoplasmic vesicle  
located_in extracellular region  
is_active_in extracellular space  
is_active_in membrane  
is_active_in neuron projection  
located_in synapse  

General protein information

Preferred Names
Neuroendocrine convertase 2
NP_001023732.1
  • Confirmed by transcript evidence
NP_001256192.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    10169177..10173753 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001028561.4NP_001023732.1  Neuroendocrine convertase 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023732.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E9P883, G5ECN9, Q18772
    Conserved Domains (3) summary
    cd04059
    Location:128423
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    pfam01483
    Location:532619
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:29107
    S8_pro-domain; Peptidase S8 pro-domain
  2. NM_001269263.3NP_001256192.1  Neuroendocrine convertase 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256192.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5ECN9
    Conserved Domains (3) summary
    cd04059
    Location:3298
    Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
    pfam00082
    Location:40302
    Peptidase_S8; Subtilase family
    pfam01483
    Location:407494
    P_proprotein; Proprotein convertase P-domain
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