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Slc25a15 solute carrier family 25 (mitochondrial carrier ornithine transporter), member 15 [ Mus musculus (house mouse) ]

Gene ID: 18408, updated on 5-Mar-2024

Summary

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Official Symbol
Slc25a15provided by MGI
Official Full Name
solute carrier family 25 (mitochondrial carrier ornithine transporter), member 15provided by MGI
Primary source
MGI:MGI:1342274
See related
Ensembl:ENSMUSG00000031482 AllianceGenome:MGI:1342274
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ornt1; D630044L02Rik
Summary
Predicted to enable L-ornithine transmembrane transporter activity. Predicted to be involved in mitochondrial L-ornithine transmembrane transport. Located in mitochondrial inner membrane. Is expressed in liver; metanephros; midgut; and retina. Human ortholog(s) of this gene implicated in amino acid metabolic disorder; citrullinemia; and ornithine translocase deficiency. Orthologous to human SLC25A15 (solute carrier family 25 member 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 48.0), large intestine adult (RPKM 23.7) and 13 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 A2; 8 11.26 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (22865566..22888637, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (22375550..22398621, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L30, pseudogene 2 Neighboring gene thrombospondin, type I, domain 1 Neighboring gene transmembrane phosphatase with tensin homology Neighboring gene predicted gene, 46035 Neighboring gene RIKEN cDNA 1810012K16 gene Neighboring gene STARR-positive B cell enhancer ABC_E6625 Neighboring gene predicted gene, 53406 Neighboring gene PDZ and LIM domain protein 5 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hyperornithinaemia-hyperammonaemia-homocitrullinuria syndrome is caused by mutations in a gene encoding a mitochondrial ornithine transporter. Camacho JA, et al. Nat Genet, 1999 Jun. PMID 10369256
  2. Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans. Calvo SE, et al. Proc Natl Acad Sci U S A, 2009 May 5. PMID 19372376, Free PMC Article
  3. Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Lumayag S, et al. Proc Natl Acad Sci U S A, 2013 Feb 5. PMID 23341629, Free PMC Article
  4. Proteomic analysis of the mouse liver mitochondrial inner membrane. Da Cruz S, et al. J Biol Chem, 2003 Oct 17. PMID 12865426
  5. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Includes the study of an upstream ORF in this gene, and shows that it functions to reduce protein levels by ~55%.
    Title: Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-arginine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables L-lysine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables L-ornithine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-ornithine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables antiporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in L-arginine transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in L-lysine transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial L-ornithine transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitochondrial ornithine transporter 1
Names
ornithine transporter, mitochondrial 1
solute carrier family 25 member 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358971.1 → NP_001345900.1  mitochondrial ornithine transporter 1

    Status: VALIDATED

    Source sequence(s)
    AC140326
    Consensus CDS
    CCDS22175.1
    UniProtKB/Swiss-Prot
    Q9WVD5
    UniProtKB/TrEMBL
    Q543E2
    Conserved Domains (1) summary
    pfam00153
    Location:205 → 296
    Mito_carr; Mitochondrial carrier protein

  2. NM_181325.4 → NP_851842.1  mitochondrial ornithine transporter 1

    See identical proteins and their annotated locations for NP_851842.1

    Status: VALIDATED

    Source sequence(s)
    AK052758, AK142223, AK145966, CJ172337, DV644804
    Consensus CDS
    CCDS22175.1
    UniProtKB/Swiss-Prot
    Q9WVD5
    UniProtKB/TrEMBL
    Q543E2
    Related
    ENSMUSP00000033871.7, ENSMUST00000033871.8
    Conserved Domains (1) summary
    pfam00153
    Location:205 → 296
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    22865566..22888637 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WVD5.1 GenPept UniProtKB/Swiss-Prot:Q9WVD5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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