Pla2g1b phospholipase A2, group IB, pancreas [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pla2g1bprovided by MGI
Official Full Name: phospholipase A2, group IB, pancreasprovided by MGI
Primary source: MGI:MGI:101842
See related: Ensembl:ENSMUSG00000029522 AllianceGenome:MGI:101842
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pla2a; sPLA2IB
Summary: Enables phospholipase A2 activity and signaling receptor binding activity. Predicted to be involved in several processes, including defense response to other organism; glycerophospholipid metabolic process; and positive regulation of glomerular visceral epithelial cell apoptotic process. Predicted to act upstream of or within phospholipid catabolic process. Located in extracellular region. Is expressed in liver; lung; and spleen. Orthologous to human PLA2G1B (phospholipase A2 group IB). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward stomach adult (RPKM 11970.9) See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 56.1 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (115604201..115612781)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (115466142..115474722)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inactivation of Group 1B Phospholipase A2 Enhances Disease Recovery and Reduces Experimental Colitis in Mice.
Title: Inactivation of Group 1B Phospholipase A(2) Enhances Disease Recovery and Reduces Experimental Colitis in Mice.
Preimplantation apoptotic endometrial caspase-3-mediated phospholipase A2 activation: a potential component in programming uterine receptivity.
Title: Preimplantation apoptotic endometrial caspase-3-mediated phospholipase A2 activation: a potential component in programming uterine receptivity.
Pla2g1b inactivation suppressed diet-induced body weight gain and reduced diabetes and atherosclerosis in LDL receptor-deficient mice.
Title: Group 1B phospholipase A₂ inactivation suppresses atherosclerosis and metabolic diseases in LDL receptor-deficient mice.
Exogenously added sPLA(2)-IB decreases phagocytosis of outer retinal segments regardless of enzymatic activity.
Title: Diverse regulation of retinal pigment epithelium phagocytosis of photoreceptor outer segments by calcium-independent phospholipase A₂, group VIA and secretory phospholipase A₂, group IB.
inhibition of Pla2g1b protects against diet-induced hyperlipidemia
Title: Group 1B phospholipase A₂ deficiency protects against diet-induced hyperlipidemia in mice.
Lysophospholipids produced by Pla2g1b hydrolysis suppress hepatic fat utilization and down-regulate energy expenditure, preventing metabolically beneficial adaptation to a high-fat diet exposure in promoting diet-induced obesity and type 2 diabetes.
Title: Postprandial lysophospholipid suppresses hepatic fatty acid oxidation: the molecular link between group 1B phospholipase A2 and diet-induced obesity.
sPLA2IB has a role in promoting MMP-2 mediated cell migration via the phosphatidylinositol 3-kinase and Akt pathway
Title: Group IB secretory phospholipase A2 promotes matrix metalloproteinase-2-mediated cell migration via the phosphatidylinositol 3-kinase and Akt pathway.
pro-inflammatory effects of Ps. aeruginosa involve release of an sPLA2 of epithelial origin that, in part, via distinct signalling molecules, transactivates the ABCA1 gene, leading to export of phospholipid.
Title: Pseudomonas aeruginosa and sPLA2 IB stimulate ABCA1-mediated phospholipid efflux via ERK-activation of PPARalpha-RXR.
Elevating plasma lysophospholipid levels in Pla2g1b deficient mice via intraperitoneal injection resulted in glucose intolerance.
Title: Group 1B phospholipase A2-mediated lysophospholipid absorption directly contributes to postprandial hyperglycemia.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

Pla2g1b (e-PCR), detects polymorphism
- UniSTS:546947

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent phospholipase A2 activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipase A2 activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phospholipase A2 activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipase A2 activity	ISO Inferred from Sequence Orthology more info
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antibacterial humoral response	ISO Inferred from Sequence Orthology more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
involved_in arachidonic acid secretion	IEA Inferred from Electronic Annotation more info
involved_in defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
involved_in fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in innate immune response in mucosa	ISO Inferred from Sequence Orthology more info
involved_in lipid catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylcholine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylglycerol metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phospholipid catabolic process	TAS Traceable Author Statement more info	PubMed
involved_in phospholipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of podocyte apoptotic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in secretory granule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: phospholipase A2

Names: PLA2-Ib; group IB phospholipase A2; phosphatidylcholine 2-acylhydrolase 1B

NP_001343515.1

EC 3.1.1.4

NP_001343516.1

EC 3.1.1.4

NP_035237.1

EC 3.1.1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356586.1 → NP_001343515.1 phospholipase A2 isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.

Source sequence(s)

AC117735, BY088109

UniProtKB/TrEMBL

D3YWH2

Related

ENSMUSP00000120743.2, ENSMUST00000125568.2

Conserved Domains (1) summary

smart00085
Location:23 → 145

PA2c; Phospholipase A2
NM_001356587.1 → NP_001343516.1 phospholipase A2 isoform 3 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AC117735, AK019009

Consensus CDS

CCDS89977.1

UniProtKB/TrEMBL

D3Z1N8

Related

ENSMUSP00000107702.2, ENSMUST00000112071.8

Conserved Domains (1) summary

cl05417
Location:24 → 65

PLA2_like; Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
NM_011107.2 → NP_035237.1 phospholipase A2 isoform 1 precursor

See identical proteins and their annotated locations for NP_035237.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC117735, AK008668

Consensus CDS

CCDS19592.1

UniProtKB/Swiss-Prot

A6H6K5, Q9D7E2, Q9D884, Q9Z0Y2

UniProtKB/TrEMBL

D3YWH2

Related

ENSMUSP00000031495.5, ENSMUST00000031495.11

Conserved Domains (1) summary

smart00085
Location:24 → 146

PA2c; Phospholipase A2

RNA

NR_151517.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because it lacks an in-frame ORF.

Source sequence(s)

AC117735