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Ctsa cathepsin A [ Mus musculus (house mouse) ]

Gene ID: 19025, updated on 5-Mar-2024

Summary

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Official Symbol
Ctsaprovided by MGI
Official Full Name
cathepsin Aprovided by MGI
Primary source
MGI:MGI:97748
See related
Ensembl:ENSMUSG00000017760 AllianceGenome:MGI:97748
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PPCA; Ppgb
Summary
This gene encodes a glycoprotein with deamidase, esterase and carboxypeptidase activities. The encoded protein associates with and provides a protective function to the lysosomal enzymes beta-galactosidase and neuraminidase. Deficiency of the related gene in humans results in galactosialidosis. The proprotein is processed into two shorter chains. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]
Expression
Ubiquitous expression in lung adult (RPKM 116.6), kidney adult (RPKM 99.9) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Ctsa in Genome Data Viewer
Location:
2 H3; 2 85.27 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (164674792..164682952)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (164832872..164841032)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_06336 Neighboring gene zinc finger SWIM-type containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E6018 Neighboring gene spermatogenesis associated 25 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:164659262-164659371 Neighboring gene neuralized E3 ubiquitin protein ligase 2 Neighboring gene phospholipid transfer protein Neighboring gene STARR-seq mESC enhancer starr_06339 Neighboring gene RIKEN cDNA 4930445K14 gene Neighboring gene STARR-positive B cell enhancer ABC_E6019 Neighboring gene STARR-positive B cell enhancer ABC_E2059 Neighboring gene phosphorylated CTD interacting factor 1 Neighboring gene predicted gene, 46775

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cathepsin A regulates pluripotency, proliferation and differentiation in mouse embryonic stem cells. Park S, et al. Cell Biochem Funct, 2021 Jan. PMID 32529664
  2. Enzymatic activity of lysosomal carboxypeptidase (cathepsin) A is required for proper elastic fiber formation and inactivation of endothelin-1. Seyrantepe V, et al. Circulation, 2008 Apr 15. PMID 18391110
  3. Structural alterations of epididymal epithelial cells in cathepsin A-deficient mice affect the blood-epididymal barrier and lead to altered sperm motility. Hermo L, et al. J Androl, 2007 Sep-Oct. PMID 17522420
  4. Characterization of cell- and region-specific abnormalities in the epididymis of cathepsin A deficient mice. Korah N, et al. Mol Reprod Dev, 2003 Dec. PMID 14579412
  5. Increase in macrophages in the testis of cathepsin a deficient mice suggests an important role for these cells in the interstitial space of this tissue. Korah N, et al. Mol Reprod Dev, 2003 Mar. PMID 12548663

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cathepsin A regulates pluripotency, proliferation and differentiation in mouse embryonic stem cells.
    Title: Cathepsin A regulates pluripotency, proliferation and differentiation in mouse embryonic stem cells.
  2. Cathepsin A contributes to left ventricular remodeling by degrading extracellular superoxide dismutase in mice.
    Title: Cathepsin A contributes to left ventricular remodeling by degrading extracellular superoxide dismutase in mice.
  3. in normal tissues the tandem of serine carboxypeptidases, Scpep1 and CathA likely constitutes an important part of the physiological mechanism responsible for the balanced elimination of heightened levels of ET-1 that otherwise would accumulate in tissues and consequently contribute to development of the hyper-proliferative corneal dystrophy and abnormal skin thickening
    Title: Mice, double deficient in lysosomal serine carboxypeptidases Scpep1 and Cathepsin A develop the hyperproliferative vesicular corneal dystrophy and hypertrophic skin thickenings.
  4. our results define the biological role of mammalian serine carboxypeptidase Scpep1 and suggest that Scpep1 and CathA together participate in the control of ET-1 regulation of vascular tone and hemodynamics
    Title: Serine carboxypeptidase SCPEP1 and Cathepsin A play complementary roles in regulation of vasoconstriction via inactivation of endothelin-1.
  5. Loss of the cathepsin A results in the lysosomal storage disease galactosialidosis. However, mice with a catalytically inactive cathepsin A enzyme show no signs of this disease.
    Title: Inhibition of CatA: an emerging strategy for the treatment of heart failure.
  6. characterization of human PPCA, including N-terminal sequencing of the two cleavage products
    Title: Expression of cDNA encoding the human "protective protein" associated with lysosomal beta-galactosidase and neuraminidase: homology to yeast proteases.
  7. Results describe the hydrodynamic properties of PPCA, NEU1, and a complex of the two proteins and identified multiple binding sites on both proteins.
    Title: Heterodimerization of the sialidase NEU1 with the chaperone protective protein/cathepsin A prevents its premature oligomerization.
  8. The N-terminal N-glycan of NEU1 is indispensable for its function, whereas the C-terminal N-glycan appears to be non-essential. The omission of the second N-glycan can be compensated for by upregulating the expression of PPCA
    Title: Protective protein/cathepsin A rescues N-glycosylation defects in neuraminidase-1.
  9. Results indicate a novel role for PPCA/cathepsin A in osteoclastogenesis via down-regulation of NF-kappaB p50/p65 activity and suggest a new function for PPCA as an NF-kappaB-degrading enzyme in addition to its known multifunctional properties.
    Title: Protective protein/cathepsin A down-regulates osteoclastogenesis by associating with and degrading NF-kappaB p50/p65.
  10. CathA acts in vivo as an endothelin-1-inactivating enzyme and strongly confirm a crucial role of this enzyme in effective elastic fiber formation.
    Title: Enzymatic activity of lysosomal carboxypeptidase (cathepsin) A is required for proper elastic fiber formation and inactivation of endothelin-1.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables serine-type carboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type carboxypeptidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of chaperone-mediated autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of chaperone-mediated autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
lysosomal protective protein
Names
carboxypeptidase C
carboxypeptidase L
protective protein cathepsin A
protective protein for beta-galactosidase
NP_001033581.1
NP_032932.2
XP_030104427.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038492.2 → NP_001033581.1  lysosomal protective protein isoform b preproprotein

    See identical proteins and their annotated locations for NP_001033581.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, and initiates translation at an alternate downstream in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AK019861, AK032197, AL591495, BY319945
    Consensus CDS
    CCDS17062.1
    UniProtKB/Swiss-Prot
    P16675, Q8VEF6
    UniProtKB/TrEMBL
    Q544R6, Q9D2D1
    Related
    ENSMUSP00000099382.4, ENSMUST00000103093.10
    Conserved Domains (1) summary
    pfam00450
    Location:34 → 470
    Peptidase_S10; Serine carboxypeptidase

  2. NM_008906.4 → NP_032932.2  lysosomal protective protein isoform a preproprotein

    See identical proteins and their annotated locations for NP_032932.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK019861, AK032197, AK159150, AL591495
    Consensus CDS
    CCDS17061.1
    UniProtKB/TrEMBL
    G3X8T3, Q9D2D1
    Conserved Domains (1) summary
    pfam00450
    Location:52 → 488
    Peptidase_S10; Serine carboxypeptidase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    164674792..164682952
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248567.2 → XP_030104427.1  lysosomal protective protein isoform X1

    UniProtKB/TrEMBL
    G3X8T3, Q9D2D1
    Related
    ENSMUSP00000099381.3, ENSMUST00000103092.9
    Conserved Domains (1) summary
    pfam00450
    Location:52 → 488
    Peptidase_S10; Serine carboxypeptidase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P16675.1 GenPept UniProtKB/Swiss-Prot:P16675

Gene LinkOut

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