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Rbbp6 retinoblastoma binding protein 6, ubiquitin ligase [ Mus musculus (house mouse) ]

Gene ID: 19647, updated on 9-May-2024

Summary

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Official Symbol
Rbbp6provided by MGI
Official Full Name
retinoblastoma binding protein 6, ubiquitin ligaseprovided by MGI
Primary source
MGI:MGI:894835
See related
Ensembl:ENSMUSG00000030779 AllianceGenome:MGI:894835
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PACT; P2P-R; 4933422O15Rik; C030034J04Rik
Summary
Predicted to enable protein kinase binding activity and ubiquitin protein ligase activity. Involved in ubiquitin-dependent protein catabolic process. Acts upstream of or within embryonic organ development; in utero embryonic development; and somite development. Predicted to be located in nuclear speck. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Predicted to colocalize with centrosome. Is expressed in left lung and right lung. Orthologous to human RBBP6 (RB binding protein 6, ubiquitin ligase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 10.8), CNS E14 (RPKM 9.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 F2; 7 67.42 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (122568980..122601780)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (122969637..123002572)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39082 Neighboring gene predicted gene, 39083 Neighboring gene RIKEN cDNA 4930413G21 gene Neighboring gene STARR-positive B cell enhancer ABC_E9705 Neighboring gene ribosomal protein L11 pseudogene Neighboring gene predicted gene, 51498

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Stable overexpression of specific segments of the P2P-R protein in human MCF-7 cells promotes camptothecin-induced apoptosis. Gao S, et al. J Cell Physiol, 2003 Dec. PMID 14566974
  2. P2P-R protein overexpression restricts mitotic progression at prometaphase and promotes mitotic apoptosis. Gao S, et al. J Cell Physiol, 2002 Nov. PMID 12384997
  3. The proliferation potential protein-related (P2P-R) gene with domains encoding heterogeneous nuclear ribonucleoprotein association and Rb1 binding shows repressed expression during terminal differentiation. Witte MM, et al. Proc Natl Acad Sci U S A, 1997 Feb 18. PMID 9037032, Free PMC Article
  4. P2P-R protein localizes to the nucleolus of interphase cells and the periphery of chromosomes in mitotic cells which show maximum P2P-R immunoreactivity. Gao S, et al. J Cell Physiol, 2002 May. PMID 12064457
  5. P2P-R expression is genetically coregulated with components of the translation machinery and with PUM2, a translational repressor that associates with the P2P-R mRNA. Scott RE, et al. J Cell Physiol, 2005 Jul. PMID 15617101

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the PACT-p53 interaction plays a critical role in embryonic development and tumorigenesis and identify PACT as a member of negative regulators of p53.
    Title: PACT is a negative regulator of p53 and essential for cell growth and embryonic development.
  2. P2P-R expression may be translationally regulated by PUM2 and that P2P-R may modulate translation by influencing ribosomal protein gene expression
    Title: P2P-R expression is genetically coregulated with components of the translation machinery and with PUM2, a translational repressor that associates with the P2P-R mRNA.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC32263

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within embryonic organ development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within somite development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
colocalizes_with centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RBBP6
Names
RING-type E3 ubiquitin transferase RBBP6
p53-associated cellular protein of testis
proliferation potential-related protein
protein P2P-R
retinoblastoma-binding protein 6
NP_001390011.1
NP_001390012.1
NP_035377.2
NP_778188.1
XP_030098102.1
XP_036008697.1
XP_036008698.1
XP_036008699.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403082.1 → NP_001390011.1  E3 ubiquitin-protein ligase RBBP6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC125221
    Related
    ENSMUSP00000155989.2, ENSMUST00000231323.2

  2. NM_001403083.1 → NP_001390012.1  E3 ubiquitin-protein ligase RBBP6 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC125221
    Related
    ENSMUSP00000071519.6, ENSMUST00000071590.6

  3. NM_011247.3 → NP_035377.2  E3 ubiquitin-protein ligase RBBP6 isoform 1

    See identical proteins and their annotated locations for NP_035377.2

    Status: VALIDATED

    Source sequence(s)
    AC125221
    Consensus CDS
    CCDS52387.1
    UniProtKB/Swiss-Prot
    P70287, P97868, Q3TTR9, Q3TUM7, Q3UMP7, Q4U217, Q7TT06, Q8BNY8, Q8R399
    UniProtKB/TrEMBL
    A0A338P6W1
    Related
    ENSMUSP00000049528.8, ENSMUST00000052135.14
    Conserved Domains (5) summary
    smart00184
    Location:260 → 300
    RING; Ring finger
    COG5222
    Location:2 → 420
    COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    pfam08783
    Location:4 → 75
    DWNN; DWNN domain
    pfam13696
    Location:157 → 177
    zf-CCHC_2; Zinc knuckle
    cl10727
    Location:992 → 1160
    DUF2042; Uncharacterized conserved protein (DUF2042)

  4. NM_175023.4 → NP_778188.1  E3 ubiquitin-protein ligase RBBP6 isoform 2

    See identical proteins and their annotated locations for NP_778188.1

    Status: VALIDATED

    Source sequence(s)
    AC125221
    Consensus CDS
    CCDS21817.1
    UniProtKB/TrEMBL
    A0A0R4J165
    Related
    ENSMUSP00000095670.3, ENSMUST00000098062.9
    Conserved Domains (1) summary
    pfam08783
    Location:4 → 75
    DWNN; DWNN domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    122568980..122601780
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152805.1 → XP_036008698.1  E3 ubiquitin-protein ligase RBBP6 isoform X4

    UniProtKB/TrEMBL
    A0A338P6W1
    Conserved Domains (2) summary
    PTZ00121
    Location:811 → 1455
    PTZ00121; MAEBL; Provisional
    COG5222
    Location:21 → 325
    COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]

  2. XM_036152806.1 → XP_036008699.1  E3 ubiquitin-protein ligase RBBP6 isoform X5

    UniProtKB/TrEMBL
    A0A338P6W1
    Conserved Domains (2) summary
    PTZ00121
    Location:773 → 1417
    PTZ00121; MAEBL; Provisional
    COG5222
    Location:21 → 287
    COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]

  3. XM_030242242.2 → XP_030098102.1  E3 ubiquitin-protein ligase RBBP6 isoform X6

    UniProtKB/TrEMBL
    A0A338P6W1
    Conserved Domains (2) summary
    PTZ00121
    Location:739 → 1383
    PTZ00121; MAEBL; Provisional
    COG5222
    Location:21 → 287
    COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]

  4. XM_036152804.1 → XP_036008697.1  E3 ubiquitin-protein ligase RBBP6 isoform X2

    UniProtKB/TrEMBL
    A0A338P6W1
    Conserved Domains (2) summary
    PTZ00121
    Location:910 → 1554
    PTZ00121; MAEBL; Provisional
    COG5222
    Location:2 → 458
    COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97868.5 GenPept UniProtKB/Swiss-Prot:P97868

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