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TXLNA taxilin alpha [ Homo sapiens (human) ]

Gene ID: 200081, updated on 19-Apr-2024

Summary

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Official Symbol
TXLNAprovided by HGNC
Official Full Name
taxilin alphaprovided by HGNC
Primary source
HGNC:HGNC:30685
See related
Ensembl:ENSG00000084652 MIM:608676; AllianceGenome:HGNC:30685
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IL14; TXLN; IL-14
Summary
Predicted to enable syntaxin binding activity. Predicted to be involved in exocytosis. Predicted to act upstream of or within B cell activation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 17.8), skin (RPKM 14.9) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
1p35.2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (32179675..32198285)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (32037572..32056187)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (32645276..32663886)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene transmembrane protein 39B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32557367-32557892 Neighboring gene microRNA 5585 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:32573351-32573869 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:32573870-32574387 Neighboring gene Sharpr-MPRA regulatory region 5670 Neighboring gene karyopherin subunit alpha 6 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:32644454-32645213 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:32645214-32645972 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 671 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 670 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32664855-32665413 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32665414-32665971 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 672 Neighboring gene H3K4me1 hESC enhancers GRCh37_chr1:32666522-32667041 and GRCh37_chr1:32667042-32667562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32670259-32670760 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 675 Neighboring gene coiled-coil domain containing 28B Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:32681346-32682545 Neighboring gene doublecortin domain containing 2B Neighboring gene IQ motif containing C Neighboring gene transmembrane protein 234

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. High TXLNA Expression Predicts Favourable Outcome for Pancreatic Adenocarcinoma Patients. Lv S, et al. Biomed Res Int, 2020. PMID 32185195, Free PMC Article
  2. Characterization of α-taxilin as a novel factor controlling the release of hepatitis C virus. Elgner F, et al. Biochem J, 2016 Jan 15. PMID 26527738
  3. Identification of α-taxilin as an essential factor for the life cycle of hepatitis B virus. Hoffmann J, et al. J Hepatol, 2013 Nov. PMID 23816704
  4. Interaction of α-taxilin localized on intracellular components with the microtubule cytoskeleton. Horii Y, et al. Cell Struct Funct, 2012. PMID 22785156
  5. Increased alpha-taxilin protein expression is associated with the metastatic and invasive potential of renal cell cancer. Mashidori T, et al. Biomed Res, 2011 Apr. PMID 21551945

See all (96) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. alpha-/gamma-Taxilin are required for centriolar subdistal appendage assembly and microtubule organization.
    Title: α-/γ-Taxilin are required for centriolar subdistal appendage assembly and microtubule organization.
  2. High TXLNA Expression Predicts Favourable Outcome for Pancreatic Adenocarcinoma Patients.
    Title: High TXLNA Expression Predicts Favourable Outcome for Pancreatic Adenocarcinoma Patients.
  3. intrathyroidal production of IL-14 and IL-16 associated with the pathogenesis of autoimmune thyroid disease
    Title: IL-14 and IL-16 are expressed in the thyroid of patients with either Graves' disease or Hashimoto's thyroiditis.
  4. Silencing of alpha-taxilin expression leads to increased release of infectious hepatitis C virus particles.
    Title: Characterization of α-taxilin as a novel factor controlling the release of hepatitis C virus.
  5. alpha-taxilin interacts with SNX4 and plays a role in the recycling pathway of TfnR.
    Title: α-Taxilin interacts with sorting nexin 4 and participates in the recycling pathway of transferrin receptor.
  6. alpha-taxilin plays an essential role for release of HBV-DNA containing particles.
    Title: Identification of α-taxilin as an essential factor for the life cycle of hepatitis B virus.
  7. Alpha-taxilin is localized on intracellular components in a syntaxin-independent manner and that the alpha-taxilin-containing intracellular components are associated with the microtubule cytoskeleton.
    Title: Interaction of α-taxilin localized on intracellular components with the microtubule cytoskeleton.
  8. Increased alpha-taxilin protein expression is associated with the metastatic and invasive potential of renal cell cancer.
    Title: Increased alpha-taxilin protein expression is associated with the metastatic and invasive potential of renal cell cancer.
  9. alpha-taxilin may be involved in cell proliferation of hepatocellular carcinoma(HCC), and its expression can be a marker of malignant potential of HCC.
    Title: Expression of α-taxilin in hepatocellular carcinoma correlates with growth activity and malignant potential of the tumor.
  10. analysis of a novel monoclonal antibody against interleukin-14alpha
    Title: Characteristics of a novel monoclonal antibody against interleukin-14alpha.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC118870, MGC118871, DKFZp451J0118

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables syntaxin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in B cell activation IEA
Inferred from Electronic Annotation
more info
  
involved_in exocytosis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular region NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane HDA PubMed 

General protein information

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Preferred Names
alpha-taxilin
Names
interleukin 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001376857.1 → NP_001363786.1  alpha-taxilin isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL049795
    Consensus CDS
    CCDS353.1
    UniProtKB/Swiss-Prot
    D3DPP6, P40222, Q5TFJ6, Q66K62, Q86T54, Q86T85, Q86T86, Q86Y86, Q86YW3, Q8N2Y3
    Related
    ENSP00000362711.1, ENST00000373609.1
    Conserved Domains (2) summary
    PRK07764
    Location:9 → 161
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    pfam09728
    Location:172 → 477
    Taxilin; Myosin-like coiled-coil protein

  2. NM_001376858.1 → NP_001363787.1  alpha-taxilin isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL049795
    Conserved Domains (1) summary
    pfam09728
    Location:1 → 302
    Taxilin; Myosin-like coiled-coil protein

  3. NM_001376859.1 → NP_001363788.1  alpha-taxilin isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL049795
    Conserved Domains (1) summary
    pfam09728
    Location:1 → 302
    Taxilin; Myosin-like coiled-coil protein

  4. NM_175852.4 → NP_787048.1  alpha-taxilin isoform 1

    See identical proteins and their annotated locations for NP_787048.1

    Status: VALIDATED

    Source sequence(s)
    AL049795, AL832338, BC029686, BC046565
    Consensus CDS
    CCDS353.1
    UniProtKB/Swiss-Prot
    D3DPP6, P40222, Q5TFJ6, Q66K62, Q86T54, Q86T85, Q86T86, Q86Y86, Q86YW3, Q8N2Y3
    Related
    ENSP00000362712.3, ENST00000373610.8
    Conserved Domains (2) summary
    PRK07764
    Location:9 → 161
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    pfam09728
    Location:172 → 477
    Taxilin; Myosin-like coiled-coil protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    32179675..32198285
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000563.2 → XP_016856052.1  alpha-taxilin isoform X1

  2. XM_011540932.3 → XP_011539234.1  alpha-taxilin isoform X2

    See identical proteins and their annotated locations for XP_011539234.1

    Conserved Domains (1) summary
    pfam09728
    Location:40 → 318
    Taxilin; Myosin-like coiled-coil protein

  3. XM_017000561.2 → XP_016856050.1  alpha-taxilin isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    32037572..32056187
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054334933.1 → XP_054190908.1  alpha-taxilin isoform X1

  2. XM_054334934.1 → XP_054190909.1  alpha-taxilin isoform X2

  3. XM_054334932.1 → XP_054190907.1  alpha-taxilin isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40222.3 GenPept UniProtKB/Swiss-Prot:P40222

Gene LinkOut

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