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Rps15 ribosomal protein S15 [ Mus musculus (house mouse) ]

Gene ID: 20054, updated on 5-Mar-2024

Summary

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Official Symbol
Rps15provided by MGI
Official Full Name
ribosomal protein S15provided by MGI
Primary source
MGI:MGI:98117
See related
Ensembl:ENSMUSG00000063457 AllianceGenome:MGI:98117
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
rig
Summary
Predicted to enable MDM2/MDM4 family protein binding activity and ubiquitin ligase inhibitor activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in positive regulation of signal transduction by p53 class mediator and ribosome biogenesis. Predicted to be located in cytosolic ribosome and nucleoplasm. Predicted to be part of cytosolic small ribosomal subunit. Orthologous to human RPS15 (ribosomal protein S15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 713.3), liver E14 (RPKM 562.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 C1; 10 39.72 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80128265..80129948)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80292431..80294114)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene DAZ associated protein 1 Neighboring gene microRNA 6911 Neighboring gene predicted gene 15122 Neighboring gene STARR-positive B cell enhancer ABC_E5154 Neighboring gene APC regulator of WNT signaling pathway 2 Neighboring gene STARR-positive B cell enhancer ABC_E8347 Neighboring gene RIKEN cDNA 2310011J03 gene Neighboring gene STARR-positive B cell enhancer ABC_E5155 Neighboring gene proprotein convertase subtilisin/kexin type 4 Neighboring gene STARR-positive B cell enhancer ABC_E366

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression of the rig gene in mouse oocytes and early embryos. Taylor KD, et al. Mol Reprod Dev, 1991 Apr. PMID 2064774
  2. Nucleotide sequence determination of mouse, chicken and Xenopus laevis rig cDNAs: the rig-encoded protein is extremely conserved during vertebrate evolution. Sugawara A, et al. Biochem Biophys Res Commun, 1990 Feb 14. PMID 2154983
  3. Expression of ribosomal protein genes in mouse oocytes and early embryos. Taylor KD, et al. Mol Reprod Dev, 1992 Mar. PMID 1554502
  4. Cloning of mouse genomic ribosomal protein L6 gene and analysis of its promoter. Wang J, et al. Biochim Biophys Acta, 2002 Jun 7. PMID 12031506
  5. Protein NPM3 interacts with the multifunctional nucleolar protein B23/nucleophosmin and inhibits ribosome biogenesis. Huang N, et al. J Biol Chem, 2005 Feb 18. PMID 15596447

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MDM2/MDM4 family protein binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin ligase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
  
involved_in rRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosomal small subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal small subunit assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosomal small subunit biogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosomal small subunit export from nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  
part_of cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic small ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
part_of cytosolic small ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  
part_of small ribosomal subunit IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
small ribosomal subunit protein uS19
Names
40S ribosomal protein S15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310726.1 → NP_001297655.1  small ribosomal subunit protein uS19 isoform 2

    See identical proteins and their annotated locations for NP_001297655.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC140229
    Consensus CDS
    CCDS78858.1
    UniProtKB/TrEMBL
    D3YTQ9, Q3UK70
    Related
    ENSMUSP00000100997.2, ENSMUST00000062674.7
    Conserved Domains (1) summary
    cl00350
    Location:1 → 116
    Ribosomal_S19; Ribosomal protein S19

  2. NM_009091.2 → NP_033117.1  small ribosomal subunit protein uS19 isoform 1

    See identical proteins and their annotated locations for NP_033117.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AA027738, AV569793
    Consensus CDS
    CCDS35978.1
    UniProtKB/Swiss-Prot
    P62843, Q52KC9
    UniProtKB/TrEMBL
    Q3UK70
    Related
    ENSMUSP00000069004.8, ENSMUST00000068408.14
    Conserved Domains (1) summary
    PTZ00096
    Location:1 → 143
    PTZ00096; 40S ribosomal protein S15; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    80128265..80129948
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62843.2 GenPept UniProtKB/Swiss-Prot:P62843

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