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Rsu1 Ras suppressor protein 1 [ Mus musculus (house mouse) ]

Gene ID: 20163, updated on 3-Apr-2024

Summary

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Official Symbol
Rsu1provided by MGI
Official Full Name
Ras suppressor protein 1provided by MGI
Primary source
MGI:MGI:103040
See related
Ensembl:ENSMUSG00000026727 AllianceGenome:MGI:103040
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RsuI; rsp-1
Summary
Acts upstream of or within Ras protein signal transduction and positive regulation of neural precursor cell proliferation. Predicted to be located in focal adhesion. Is expressed in brain and telencephalon. Orthologous to human RSU1 (Ras suppressor protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 59.3), subcutaneous fat pad adult (RPKM 30.5) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 A1; 2 9.73 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (13081778..13276116, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (13076967..13271438, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene phosphotriesterase related Neighboring gene STARR-seq mESC enhancer starr_03698 Neighboring gene predicted gene, 52597 Neighboring gene C1q-like 3 Neighboring gene STARR-seq mESC enhancer starr_03699 Neighboring gene STARR-positive B cell enhancer ABC_E5887 Neighboring gene STARR-positive B cell enhancer ABC_E1000 Neighboring gene STARR-positive B cell enhancer ABC_E5888 Neighboring gene STARR-seq mESC enhancer starr_03701 Neighboring gene STARR-seq mESC enhancer starr_03702 Neighboring gene predicted gene 13270 Neighboring gene cubilin Neighboring gene predicted gene, 57686

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Human RSU1 is highly homologous to mouse Rsu-1 and localizes to human chromosome 10. Tsuda T, et al. Genomics, 1993 Nov. PMID 8288261
  2. PINCH-1 promotes Bcl-2-dependent survival signalling and inhibits JNK-mediated apoptosis in the primitive endoderm. Montanez E, et al. J Cell Sci, 2012 Nov 1. PMID 22946061
  3. Isolation of rsp-1, a novel cDNA capable of suppressing v-Ras transformation. Cutler ML, et al. Mol Cell Biol, 1992 Sep. PMID 1508180, Free PMC Article
  4. The Ras suppressor Rsu-1 binds to the LIM 5 domain of the adaptor protein PINCH1 and participates in adhesion-related functions. Dougherty GW, et al. Exp Cell Res, 2005 May 15. PMID 15878342
  5. Dissecting integrin-dependent regulation of neural stem cell proliferation in the adult brain. Porcheri C, et al. J Neurosci, 2014 Apr 9. PMID 24719101, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rsu-1 interacts with the LIM 5 domain of PINCH1 in mammalian cells and functions, in part, by altering cell adhesion.
    Title: The Ras suppressor Rsu-1 binds to the LIM 5 domain of the adaptor protein PINCH1 and participates in adhesion-related functions.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Ras protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of neural precursor cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of neural precursor cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ras suppressor protein 1
Names
rsu-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001420897.1 → NP_001407826.1  ras suppressor protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL928807, AL929209, AL935271

  2. NM_001420898.1 → NP_001407827.1  ras suppressor protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL928807, AL929209, AL935271
    UniProtKB/TrEMBL
    A2AUR7

  3. NM_001420899.1 → NP_001407828.1  ras suppressor protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL928807, AL935271
    UniProtKB/TrEMBL
    Q3TFN7

  4. NM_001420900.1 → NP_001407829.1  ras suppressor protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL928807, AL929209, AL935271

  5. NM_001420901.1 → NP_001407830.1  ras suppressor protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL928807, AL929209, AL935271

  6. NM_001420902.1 → NP_001407831.1  ras suppressor protein 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL928807, AL929209, AL935271

  7. NM_001420903.1 → NP_001407832.1  ras suppressor protein 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL928807, AL935271

  8. NM_001420904.1 → NP_001407833.1  ras suppressor protein 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL928807, AL935271

  9. NM_001420905.1 → NP_001407834.1  ras suppressor protein 1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL928807

  10. NM_009105.5 → NP_033131.2  ras suppressor protein 1 isoform 1

    See identical proteins and their annotated locations for NP_033131.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL928807, AL929209, AL935271
    Consensus CDS
    CCDS15693.1
    UniProtKB/Swiss-Prot
    Q01730
    UniProtKB/TrEMBL
    Q9D031
    Related
    ENSMUSP00000028059.3, ENSMUST00000028059.9
    Conserved Domains (2) summary
    COG4886
    Location:38 → 202
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:19 → 41
    LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    13081778..13276116 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q01730.3 GenPept UniProtKB/Swiss-Prot:Q01730

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