Scin scinderin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Scinprovided by MGI
Official Full Name: scinderinprovided by MGI
Primary source: MGI:MGI:1306794
See related: Ensembl:ENSMUSG00000002565 AllianceGenome:MGI:1306794
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: adseverin
Summary: Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in several processes, including actin polymerization or depolymerization; positive regulation of megakaryocyte differentiation; and regulation of actin filament organization. Located in brush border. Is expressed in several structures, including adrenal gland; intestine; metanephros; stomach; and thymus. Orthologous to human SCIN (scinderin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in colon adult (RPKM 56.3), large intestine adult (RPKM 22.6) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 B1; 12 18.06 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (40109768..40184227, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (40059769..40134228, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Autophagy regulation and protein kinase activity of PIK3C3 controls sertoli cell polarity through its negative regulation on SCIN (scinderin).
Title: Autophagy regulation and protein kinase activity of PIK3C3 controls sertoli cell polarity through its negative regulation on SCIN (scinderin).
Adseverin, an actin-binding protein, modulates hypertrophic chondrocyte differentiation and osteoarthritis progression.
Title: Adseverin, an actin-binding protein, modulates hypertrophic chondrocyte differentiation and osteoarthritis progression.
Scinderin promotes fusion of electron transport chain dysfunctional muscle stem cells with myofibers.
Title: Scinderin promotes fusion of electron transport chain dysfunctional muscle stem cells with myofibers.
IL1beta and TNFalpha enhance RANKL-dependent expression of adseverin, which contributes to fusion processes in osteoclastogenesis
Title: IL1β and TNFα promote RANKL-dependent adseverin expression and osteoclastogenesis.
indicate that in healthy, developing tissues, adseverin contributes to the regulation of osteoclast structure but not to bone metabolism in vivo
Title: Deletion of Adseverin in Osteoclasts Affects Cell Structure But Not Bone Metabolism.
Adseverin knockdown also suppressed the RANKL-mediated induction of nuclear factor of activated T-cell c1 (NFATc1), which is a key transcription factor in osteoclastogenesis.
Title: Adseverin mediates RANKL-induced osteoclastogenesis by regulating NFATc1.
Data indicate that adseverin (Ads) regulates actin cytoskeleton in osteoclasts.
Title: Adseverin plays a role in osteoclast differentiation and periodontal disease-mediated bone loss.
Ads is a RANKL induced early regulator of osteoclastogenesis with a potential role in pre-osteoclast differentiation and fusion.
Title: The actin binding protein adseverin regulates osteoclastogenesis.
Overexpression of Scin is associated with asthma.
Title: New asthma biomarkers: lessons from murine models of acute and chronic asthma.
adseverin induction is a specific gene regulatory effect by TCDD on thymocytes.
Title: Dioxin-induced adseverin expression in the mouse thymus is strictly regulated and dependent on the aryl hydrocarbon receptor.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Chemically induced (ENU) (1)
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SCIN (e-PCR)
- UniSTS:503605

fb15g10.x1 (e-PCR)
- UniSTS:202953

AW545522 (e-PCR)
- UniSTS:160204

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-4,5-bisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin filament capping	ISO Inferred from Sequence Orthology more info
involved_in actin filament severing	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament severing	ISO Inferred from Sequence Orthology more info
involved_in actin polymerization or depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in barbed-end actin filament capping	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell projection assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of actin nucleation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of megakaryocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in sequestering of actin monomers	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in brush border	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: scinderin

Names: gelsolin-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001146196.1 → NP_001139668.1 scinderin isoform 1

See identical proteins and their annotated locations for NP_001139668.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

BC063328, BY201136, Y13971

Consensus CDS

CCDS49055.1

UniProtKB/Swiss-Prot

O08988, O08990, Q60604, Q6P4N8

UniProtKB/TrEMBL

Q69Z71

Related

ENSMUSP00000002640.6, ENSMUST00000002640.6

Conserved Domains (6) summary

cd11288
Location:508 → 598

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:136 → 225

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:10 → 121

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:613 → 711

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:246 → 346

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:390 → 486

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
NM_009132.2 → NP_033158.2 scinderin isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks two exons in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.

Source sequence(s)

AK136080, BY201136, Y13971

Consensus CDS

CCDS25891.1

UniProtKB/TrEMBL

Q69Z71

Related

ENSMUSP00000077573.8, ENSMUST00000078481.14

Conserved Domains (5) summary

cd11289
Location:136 → 225

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:10 → 121

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:509 → 611

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:246 → 346

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:390 → 486

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins