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Shc1 src homology 2 domain-containing transforming protein C1 [ Mus musculus (house mouse) ]

Gene ID: 20416, updated on 26-Mar-2024

Summary

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Official Symbol
Shc1provided by MGI
Official Full Name
src homology 2 domain-containing transforming protein C1provided by MGI
Primary source
MGI:MGI:98296
See related
Ensembl:ENSMUSG00000042626 AllianceGenome:MGI:98296
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Shc; p66; ShcA; p66shc
Summary
Enables epidermal growth factor binding activity; identical protein binding activity; and signaling receptor binding activity. Acts upstream of or within several processes, including actin cytoskeleton reorganization; circulatory system development; and positive regulation of MAPK cascade. Predicted to be located in endosome membrane and nucleus. Predicted to be part of Shc-EGFR complex. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; heart; liver; skeleton; and skin. Orthologous to human SHC1 (SHC adaptor protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 33.0), ovary adult (RPKM 32.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Shc1 in Genome Data Viewer
Location:
3 F1; 3 39.11 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89325858..89337336)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89418551..89430029)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene flavin adenine dinucleotide synthetase 1 Neighboring gene STARR-positive B cell enhancer ABC_E70 Neighboring gene STARR-seq mESC enhancer starr_08239 Neighboring gene CDC28 protein kinase 1b Neighboring gene pygopus 2 Neighboring gene STARR-positive B cell enhancer ABC_E2080 Neighboring gene STARR-positive B cell enhancer ABC_E9557 Neighboring gene pre B cell leukemia transcription factor interacting protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The longevity protein p66(Shc) is required for neonatal heart regeneration. Huang C, et al. J Mol Cell Cardiol, 2023 Apr. PMID 36827872
  2. LONG NONCODING RNA UPREGULATES ADAPTER SHCA PROTEIN EXPRESSION TO PROMOTE COGNITIVE IMPAIRMENT AFTER CARDIAC ARREST AND RESUSCITATION. Zhang YH, et al. Shock, 2022 Aug 1. PMID 35953462
  3. Piperazine ferulate attenuates high glucose‑induced mesangial cell injury via the regulation of p66(Shc). Yang YY, et al. Mol Med Rep, 2021 May. PMID 33760157, Free PMC Article
  4. Lack of Contribution of p66shc to Pressure Overload-Induced Right Heart Hypertrophy. Hirschhäuser C, et al. Int J Mol Sci, 2020 Dec 8. PMID 33302436, Free PMC Article
  5. Protective Effects of ShcA Protein Silencing for Photothrombotic Cerebral Infarction. Hwang JA, et al. Transl Stroke Res, 2021 Oct. PMID 33242144

See all (289) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. p66Shc signaling and autophagy impact on C2C12 myoblast differentiation during senescence.
    Title: p66Shc signaling and autophagy impact on C2C12 myoblast differentiation during senescence.
  2. The Role of the Redox Enzyme p66Shc in Biological Aging of the Lung.
    Title: The Role of the Redox Enzyme p66Shc in Biological Aging of the Lung.
  3. Hyperglycemic stress induces oxidative damage of enteric glial cells by triggering redoxosomes/p66SHC activation.
    Title: Hyperglycemic stress induces oxidative damage of enteric glial cells by triggering redoxosomes/p66SHC activation.
  4. [Study of senescence protein p66[Shc] on myocardial tissue repair in adult mice].
    Title: [Study of senescence protein p66(Shc) on myocardial tissue repair in adult mice].
  5. SIRT1 attenuates blood-spinal cord barrier disruption after spinal cord injury by deacetylating p66Shc.
    Title: SIRT1 attenuates blood-spinal cord barrier disruption after spinal cord injury by deacetylating p66Shc.
  6. Mitochondrial Translocation of P66Shc Aggravates Cisplatin-induced AKI by Promoting Ferroptosis.
    Title: Mitochondrial Translocation of P66Shc Aggravates Cisplatin-induced AKI by Promoting Ferroptosis.
  7. USP15 regulates p66Shc stability associated with Drp1 activation in liver ischemia/reperfusion.
    Title: USP15 regulates p66Shc stability associated with Drp1 activation in liver ischemia/reperfusion.
  8. LONG NONCODING RNA UPREGULATES ADAPTER SHCA PROTEIN EXPRESSION TO PROMOTE COGNITIVE IMPAIRMENT AFTER CARDIAC ARREST AND RESUSCITATION.
    Title: LONG NONCODING RNA UPREGULATES ADAPTER SHCA PROTEIN EXPRESSION TO PROMOTE COGNITIVE IMPAIRMENT AFTER CARDIAC ARREST AND RESUSCITATION.
  9. ShcA promotes chondrocyte hypertrophic commitment and osteoarthritis in mice through RunX2 nuclear translocation and YAP1 inactivation.
    Title: ShcA promotes chondrocyte hypertrophic commitment and osteoarthritis in mice through RunX2 nuclear translocation and YAP1 inactivation.
  10. Genetic deletion of p66shc and/or cyclophilin D results in decreased pulmonary vascular tone.
    Title: Genetic deletion of p66shc and/or cyclophilin D results in decreased pulmonary vascular tone.
Submit: New GeneRIF Correction See all GeneRIFs (150)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ephrin receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ephrin receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables epidermal growth factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables epidermal growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables insulin receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables insulin-like growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables neurotrophin TRKA receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphotyrosine residue binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase 2A binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables receptor tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables receptor tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane receptor protein tyrosine kinase adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to growth factor stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within epidermal growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in insulin-like growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in insulin-like growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell proliferation in bone marrow ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of superoxide metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in response to endothelin ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Shc-EGFR complex ISO
Inferred from Sequence Orthology
more info
  
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
SHC-transforming protein 1
Names
SH2 domain protein C1
SHC-transforming protein A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113331.2 → NP_001106802.1  SHC-transforming protein 1 isoform a

    See identical proteins and their annotated locations for NP_001106802.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK049357, BB458154, BB656759, BQ031241
    Consensus CDS
    CCDS50962.1
    UniProtKB/Swiss-Prot
    P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7
    Related
    ENSMUSP00000091940.4, ENSMUST00000094378.10
    Conserved Domains (2) summary
    cd09925
    Location:476 → 578
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:146 → 317
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

  2. NM_011368.5 → NP_035498.2  SHC-transforming protein 1 isoform b

    See identical proteins and their annotated locations for NP_035498.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant 1. The resulting isoform (b) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AK049357, BB458154, BQ031241, BY341731
    Consensus CDS
    CCDS17508.1
    UniProtKB/Swiss-Prot
    P98083
    Related
    ENSMUSP00000140336.2, ENSMUST00000191485.7
    Conserved Domains (2) summary
    cd09925
    Location:366 → 468
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:36 → 207
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    89325858..89337336
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P98083.3 GenPept UniProtKB/Swiss-Prot:P98083

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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