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St3gal2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 [ Mus musculus (house mouse) ]

Gene ID: 20444, updated on 9-May-2024

Summary

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Official Symbol
St3gal2provided by MGI
Official Full Name
ST3 beta-galactoside alpha-2,3-sialyltransferase 2provided by MGI
Primary source
MGI:MGI:99427
See related
Ensembl:ENSMUSG00000031749 AllianceGenome:MGI:99427
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Siat5; ST3GalII
Summary
Enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity. Involved in ganglioside biosynthetic process via lactosylceramide. Acts upstream of or within protein glycosylation. Predicted to be located in Golgi membrane. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; liver; and mammary gland. Orthologous to human ST3GAL2 (ST3 beta-galactoside alpha-2,3-sialyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 32.2), cerebellum adult (RPKM 15.1) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 E1; 8 57.81 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (111646520..111699132)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (110919743..110974058)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene splicing factor 3b, subunit 3 Neighboring gene STARR-seq mESC enhancer starr_22685 Neighboring gene STARR-positive B cell enhancer ABC_E11398 Neighboring gene component of oligomeric golgi complex 4 Neighboring gene fucose kinase Neighboring gene STARR-positive B cell enhancer ABC_E9743 Neighboring gene STARR-positive B cell enhancer ABC_E8264 Neighboring gene predicted gene, 26132 Neighboring gene predicted gene, 46052 Neighboring gene predicted gene, 39251 Neighboring gene STARR-positive B cell enhancer ABC_E1770 Neighboring gene DEAD box helicase 19a Neighboring gene STARR-seq mESC enhancer starr_22687 Neighboring gene predicted gene, 51551 Neighboring gene DEAD box helicase 19b Neighboring gene microRNA 3473d

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mice lacking sialyltransferase ST3Gal-II develop late-onset obesity and insulin resistance. Lopez PH, et al. Glycobiology, 2017 Jan. PMID 27683310, Free PMC Article
  2. Adult onset cardiac dilatation in a transgenic mouse line with Galβ1,3GalNAc α2,3-sialyltransferase II (ST3Gal-II) transgenes: a new model for dilated cardiomyopathy. Suzuki O, et al. Proc Jpn Acad Ser B Phys Biol Sci, 2011. PMID 21986317, Free PMC Article
  3. Sialylation regulates brain structure and function. Yoo SW, et al. FASEB J, 2015 Jul. PMID 25846372, Free PMC Article
  4. GT1b functions as a novel endogenous agonist of toll-like receptor 2 inducing neuropathic pain. Lim H, et al. EMBO J, 2020 Mar 16. PMID 32030804, Free PMC Article
  5. Characterization of expression of glycan ligands for Siglec-F in normal mouse lungs. Guo JP, et al. Am J Respir Cell Mol Biol, 2011 Feb. PMID 20395633, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sialyltransferase Mutations Alter the Expression of Calcium-Binding Interneurons in Mice Neocortex, Hippocampus and Striatum.
    Title: Sialyltransferase Mutations Alter the Expression of Calcium-Binding Interneurons in Mice Neocortex, Hippocampus and Striatum.
  2. GT1b functions as a novel endogenous agonist of toll-like receptor 2 inducing neuropathic pain.
    Title: GT1b functions as a novel endogenous agonist of toll-like receptor 2 inducing neuropathic pain.
  3. t3gal2-null mice display a reduced respiratory exchange ratio compared to WT mice, indicating a preference for lipid oxidation as an energy source. Despite their altered metabolism, St3gal2-null mice were hyperactive. We conclude that altered ganglioside expression in adipose tissue results in diminished IR sensitivity and late-onset obesity.
    Title: Mice lacking sialyltransferase ST3Gal-II develop late-onset obesity and insulin resistance.
  4. St3gal2/3 double-null mice displayed dysmyelination marked by a reduction in major myelin proteins, fewer myelinated axons, a decrease in myelin thickness, possibly by dysregulation of ganglioside-mediated oligodendroglial precursor cell proliferation.
    Title: Sialylation regulates brain structure and function.
  5. An adult onset cardiac dilatation in a transgenic mouse line with Galbeta1,3GalNAc alpha2,3-sialyltransferase II (ST3Gal-II) transgenes, is reported.
    Title: Adult onset cardiac dilatation in a transgenic mouse line with Galβ1,3GalNAc α2,3-sialyltransferase II (ST3Gal-II) transgenes: a new model for dilated cardiomyopathy.
  6. was not found to play a role in regulating synthesis of selectin ligands nor in vitro rolling of marrow-derived neutrophils on E- or P-selectins presented by Chinese hamster ovary cells
    Title: Sialyltransferase specificity in selectin ligand formation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (2)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase ISO
Inferred from Sequence Orthology
more info
  
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ganglioside biosynthetic process via lactosylceramide IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ganglioside biosynthetic process via lactosylceramide IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ganglioside biosynthetic process via lactosylceramide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ganglioside biosynthetic process via lactosylceramide ISO
Inferred from Sequence Orthology
more info
  
involved_in globoside biosynthetic process via lactosylceramide ISO
Inferred from Sequence Orthology
more info
  
involved_in glycolipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycoprotein biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid glycosylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in oligosaccharide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein glycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein sialylation ISO
Inferred from Sequence Orthology
more info
  
involved_in sialylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sialylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2
Names
SIAT4-B
ST3Gal II
ST3GalA.2
alpha 2,3-ST 2
beta-galactoside alpha-2,3-sialyltransferase 2
gal-NAc6S
gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase
monosialoganglioside sialyltransferase
sialyltransferase 4B
sialyltransferase 5
NP_001411820.1
NP_001411821.1
NP_033205.2
XP_006530850.1
XP_006530851.1
XP_036009743.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001424891.1 → NP_001411820.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2

    Status: VALIDATED

    Source sequence(s)
    AC132945
    UniProtKB/Swiss-Prot
    Q11204, Q8BPL0

  2. NM_001424892.1 → NP_001411821.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2

    Status: VALIDATED

    Source sequence(s)
    AC132945
    UniProtKB/Swiss-Prot
    Q11204, Q8BPL0

  3. NM_009179.4 → NP_033205.2  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2

    See identical proteins and their annotated locations for NP_033205.2

    Status: VALIDATED

    Source sequence(s)
    AC132945
    Consensus CDS
    CCDS22667.1
    UniProtKB/Swiss-Prot
    Q11204, Q8BPL0
    UniProtKB/TrEMBL
    Q8BSA0, Q91WH6
    Related
    ENSMUSP00000034197.5, ENSMUST00000034197.5
    Conserved Domains (1) summary
    pfam00777
    Location:94 → 348
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    111646520..111699132
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530787.4 → XP_006530850.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 isoform X1

    See identical proteins and their annotated locations for XP_006530850.1

    UniProtKB/Swiss-Prot
    Q11204, Q8BPL0
    UniProtKB/TrEMBL
    Q8BSA0, Q91WH6
    Conserved Domains (1) summary
    pfam00777
    Location:94 → 348
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  2. XM_006530788.3 → XP_006530851.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 isoform X1

    See identical proteins and their annotated locations for XP_006530851.1

    UniProtKB/Swiss-Prot
    Q11204, Q8BPL0
    UniProtKB/TrEMBL
    Q8BSA0, Q91WH6
    Conserved Domains (1) summary
    pfam00777
    Location:94 → 348
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  3. XM_036153850.1 → XP_036009743.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 isoform X1

    UniProtKB/Swiss-Prot
    Q11204, Q8BPL0
    UniProtKB/TrEMBL
    Q8BSA0, Q91WH6
    Conserved Domains (1) summary
    pfam00777
    Location:94 → 348
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q11204.2 GenPept UniProtKB/Swiss-Prot:Q11204

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