Slc16a1 solute carrier family 16 (monocarboxylic acid transporters), member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc16a1provided by MGI
Official Full Name: solute carrier family 16 (monocarboxylic acid transporters), member 1provided by MGI
Primary source: MGI:MGI:106013
See related: Ensembl:ENSMUSG00000032902 AllianceGenome:MGI:106013
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mct1
Summary: Enables lactate transmembrane transporter activity. Involved in several processes, including behavioral response to nutrient; plasma membrane lactate transport; and regulation of insulin secretion. Located in plasma membrane and synapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 7. Orthologous to human SLC16A1 (solute carrier family 16 member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in colon adult (RPKM 55.3), placenta adult (RPKM 47.0) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F2.2; 3 45.7 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (104545980..104565778)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (104638664..104658462)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis.
Title: Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis.
MCT1-dependent energetic failure and neuroinflammation underlie optic nerve degeneration in Wolfram syndrome mice.
Title: MCT1-dependent energetic failure and neuroinflammation underlie optic nerve degeneration in Wolfram syndrome mice.
Inhibition of the Monocarboxylate Transporter 1 (MCT1) Promotes 3T3-L1 Adipocyte Proliferation and Enhances Insulin Sensitivity.
Title: Inhibition of the Monocarboxylate Transporter 1 (MCT1) Promotes 3T3-L1 Adipocyte Proliferation and Enhances Insulin Sensitivity.
Monocarboxylate transporter functions and neuroprotective effects of valproic acid in experimental models of amyotrophic lateral sclerosis.
Title: Monocarboxylate transporter functions and neuroprotective effects of valproic acid in experimental models of amyotrophic lateral sclerosis.
Macrophage monocarboxylate transporter 1 promotes peripheral nerve regeneration after injury in mice.
Title: Macrophage monocarboxylate transporter 1 promotes peripheral nerve regeneration after injury in mice.
MCT1 deletion in Schwann cells impairs both their glycolytic and mitochondrial functions.
Title: Monocarboxylate transporter 1 in Schwann cells contributes to maintenance of sensory nerve myelination during aging.
Knockdown of MCT1 suppressed glycolysis rate and decreased LPS-induced expression of iNOS, interleukin-1beta (IL-1beta), IL-6, and phosphorylation of STAT1 in BV2 cells.
Title: Monocarboxylate transporter 1 promotes classical microglial activation and pro-inflammatory effect via 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3.
Antioxidants blocked the effects of MCT1 inhibition on metastasis
Title: Metabolic heterogeneity confers differences in melanoma metastatic potential.
Deletion of MCT1 also causes morphological changes in the organization of the seminiferous tubules and on Sertoli cell morphology resulting in failure of spermatogenesis with depletion of germ cells and total absence of spermatozoa.
Title: Knockout of MCT1 results in total absence of spermatozoa, sex hormones dysregulation, and morphological alterations in the testicular tissue.
Silencing of monocarboxylate transporter-1 (Mct-1) by its siRNA suppressed the expression of marker genes for osteoblast differentiation induced by BMP-2 in mouse myoblastic C2C12 cells and in mouse primary osteoblasts. This suppression was abolished by co-transfection of Trp53 siRNA. Together, these results suggest that Mct-1 functions as a positive regulator of osteoblast differentiation via suppression of p53.
Title: Monocarboxylate transporter-1 promotes osteoblast differentiation via suppression of p53, a negative regulator of osteoblast differentiation.

Submit: New GeneRIF Correction See all GeneRIFs (39)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (3) 1 citation
Endonuclease-mediated (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BI294019 (e-PCR)
- UniSTS:246041

NoName (e-PCR)
- UniSTS:234790

Slc16a1 (e-PCR), detects polymorphism
- UniSTS:461930

RH125336 (e-PCR)
- UniSTS:162158

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carboxylic acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lactate transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables lactate:proton symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables lactate:proton symporter activity	ISO Inferred from Sequence Orthology more info
enables monocarboxylic acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables organic cyclic compound binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables solute:proton symporter activity	ISO Inferred from Sequence Orthology more info
enables succinate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables symporter activity	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in behavioral response to nutrient	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in carboxylic acid transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in cellular response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
involved_in centrosome cycle	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lactate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monocarboxylic acid transport	ISO Inferred from Sequence Orthology more info
involved_in plasma membrane lactate transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in plasma membrane lactate transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plasma membrane lactate transport	ISO Inferred from Sequence Orthology more info
involved_in pyruvate catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pyruvate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to food	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in succinate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: monocarboxylate transporter 1

Names: solute carrier family 16 member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009196.4 → NP_033222.1 monocarboxylate transporter 1

See identical proteins and their annotated locations for NP_033222.1

Status: VALIDATED

Source sequence(s)

AK033516, BY729217

Consensus CDS

CCDS17702.1

UniProtKB/Swiss-Prot

P53986

UniProtKB/TrEMBL

Q3TRK9, Q544N9, Q8C2E6

Related

ENSMUSP00000045216.2, ENSMUST00000046212.2

Conserved Domains (2) summary

cd06174
Location:20 → 432

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR00892
Location:1 → 466

2A0113; monocarboxylate transporter 1