Slc5a1 solute carrier family 5 (sodium/glucose cotransporter), member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc5a1provided by MGI
Official Full Name: solute carrier family 5 (sodium/glucose cotransporter), member 1provided by MGI
Primary source: MGI:MGI:107678
See related: Ensembl:ENSMUSG00000011034 AllianceGenome:MGI:107678
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sglt1
Summary: Enables glucose transmembrane transporter activity. Involved in regulation of transporter activity. Acts upstream of or within glucose transmembrane transport; intestinal absorption; and metanephros development. Located in apical plasma membrane and brush border. Is expressed in alimentary system; brain; and urinary system. Orthologous to human SLC5A1 (solute carrier family 5 member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in duodenum adult (RPKM 227.7), small intestine adult (RPKM 214.0) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 B1; 5 17.46 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (33261563..33320043)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (33104219..33162699)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Involvement of sodium-glucose cotransporter-1 activities in maintaining oscillatory Cl[-] currents from mouse submandibular acinar cells.
Title: Involvement of sodium-glucose cotransporter-1 activities in maintaining oscillatory Cl(-) currents from mouse submandibular acinar cells.
Deletion of the Sodium Glucose Cotransporter 1 (Sglt-1) impairs mouse sperm movement.
Title: Deletion of the Sodium Glucose Cotransporter 1 (Sglt-1) impairs mouse sperm movement.
Increased intestinal permeability and downregulation of absorptive ion transporters Nhe3, Dra, and Sglt1 contribute to diarrhea during Clostridioides difficile infection.
Title: Increased intestinal permeability and downregulation of absorptive ion transporters Nhe3, Dra, and Sglt1 contribute to diarrhea during Clostridioides difficile infection.
The sodium-glucose cotransporter isoform 1 (SGLT-1) is important for sperm energetics, motility, and fertilitydagger.
Title: The sodium-glucose cotransporter isoform 1 (SGLT-1) is important for sperm energetics, motility, and fertility†.
Glycaemia and body weight are regulated by sodium-glucose cotransporter 1 (SGLT1) expression via O-GlcNAcylation in the intestine.
Title: Glycaemia and body weight are regulated by sodium-glucose cotransporter 1 (SGLT1) expression via O-GlcNAcylation in the intestine.
Role of the macula densa sodium glucose cotransporter type 1-neuronal nitric oxide synthase-tubuloglomerular feedback pathway in diabetic hyperfiltration.
Title: Role of the macula densa sodium glucose cotransporter type 1-neuronal nitric oxide synthase-tubuloglomerular feedback pathway in diabetic hyperfiltration.
Inhibition of SGLT1 Alleviates the Glycemic Variability-Induced Cardiac Fibrosis via Inhibition of Activation of Macrophage and Cardiac Fibroblasts.
Title: Inhibition of SGLT1 Alleviates the Glycemic Variability-Induced Cardiac Fibrosis via Inhibition of Activation of Macrophage and Cardiac Fibroblasts.
Expression of SGLT1 in the Mouse Endometrial Epithelium and its Role in Early Embryonic Development and Implantation.
Title: Expression of SGLT1 in the Mouse Endometrial Epithelium and its Role in Early Embryonic Development and Implantation.
Glucose fluctuation accelerates cardiac injury of diabetic mice via sodium-dependent glucose cotransporter 1 (SGLT1).
Title: Glucose fluctuation accelerates cardiac injury of diabetic mice via sodium-dependent glucose cotransporter 1 (SGLT1).
SGLT1 participates in the development of vascular cognitive impairment in a mouse model of small vessel disease.
Title: SGLT1 participates in the development of vascular cognitive impairment in a mouse model of small vessel disease.

Submit: New GeneRIF Correction See all GeneRIFs (54)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (1) 1 citation
Endonuclease-mediated (3)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables D-glucose transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables alpha-glucoside transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables galactose:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables glucose transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables glucose transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables glucose:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucose:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables glucose:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables symporter activity	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables water transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in alpha-glucoside transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within carbohydrate transport	IEA Inferred from Electronic Annotation more info
involved_in glucose import across plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucose transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glucose transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in intestinal D-glucose absorption	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intestinal absorption	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within metanephros development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of transporter activity	IDA Inferred from Direct Assay more info	PubMed
involved_in renal glucose absorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to inorganic substance	ISO Inferred from Sequence Orthology more info
involved_in sodium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transepithelial water transport	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in transport across blood-brain barrier	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in brush border	IDA Inferred from Direct Assay more info	PubMed
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in intracellular organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sodium/glucose cotransporter 1

Names: Na(+)/glucose cotransporter 1; high affinity sodium-glucose cotransporter; solute carrier family 5, member 1; solute carrier family 5, member alpha 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.