Snai2 snail family zinc finger 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Snai2provided by MGI
Official Full Name: snail family zinc finger 2provided by MGI
Primary source: MGI:MGI:1096393
See related: Ensembl:ENSMUSG00000022676 AllianceGenome:MGI:1096393
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Slug; Slugh; Snail2
Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and chromatin binding activity. Involved in several processes, including desmosome disassembly; mesenchyme development; and sensory perception of sound. Acts upstream of or within several processes, including animal organ morphogenesis; negative regulation of cell adhesion involved in substrate-bound cell migration; and negative regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; embryo mesenchyme; and genitourinary system. Used to study Waardenburg syndrome type 2D. Human ortholog(s) of this gene implicated in Waardenburg syndrome type 2D and piebaldism. Orthologous to human SNAI2 (snail family transcriptional repressor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in limb E14.5 (RPKM 17.7), mammary gland adult (RPKM 5.5) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 A1; 16 10.07 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (14523716..14527259)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (14705852..14709395)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hepatic Snai1 and Snai2 promote liver regeneration and suppress liver fibrosis in mice.
Title: Hepatic Snai1 and Snai2 promote liver regeneration and suppress liver fibrosis in mice.
SNAI2 promotes the malignant transformation of oral leukoplakia by modulating p-EMT.
Title: SNAI2 promotes the malignant transformation of oral leukoplakia by modulating p-EMT.
Long Noncoding RNA MIAT Modulates Chronic Retinal Ischemia-Reperfusion Injury in Mice via the microRNA-203-3p/SNAI2 Axis.
Title: Long Noncoding RNA MIAT Modulates Chronic Retinal Ischemia-Reperfusion Injury in Mice via the microRNA-203-3p/SNAI2 Axis.
Slug, a Stress-Induced Transcription Factor, Stimulates Herpes Simplex Virus 1 Replication and Transactivates a cis-Regulatory Module within the VP16 Promoter.
Title: Slug, a Stress-Induced Transcription Factor, Stimulates Herpes Simplex Virus 1 Replication and Transactivates a cis-Regulatory Module within the VP16 Promoter.
LepRb+ cell-specific deletion of Slug mitigates obesity and nonalcoholic fatty liver disease in mice.
Title: LepRb+ cell-specific deletion of Slug mitigates obesity and nonalcoholic fatty liver disease in mice.
Irradiation Activates MZF1 to Inhibit miR-541-5p Expression and Promote Epithelial-Mesenchymal Transition (EMT) in Radiation-Induced Pulmonary Fibrosis (RIPF) by Upregulating Slug.
Title: Irradiation Activates MZF1 to Inhibit miR-541-5p Expression and Promote Epithelial-Mesenchymal Transition (EMT) in Radiation-Induced Pulmonary Fibrosis (RIPF) by Upregulating Slug.
Inhibitory role of miR-203 in the angiogenesis of mice with pathological retinal neovascularization disease through downregulation of SNAI2.
Title: Inhibitory role of miR-203 in the angiogenesis of mice with pathological retinal neovascularization disease through downregulation of SNAI2.
Hepatic Slug epigenetically promotes liver lipogenesis, fatty liver disease, and type 2 diabetes.
Title: Hepatic Slug epigenetically promotes liver lipogenesis, fatty liver disease, and type 2 diabetes.
Snai2 Maintains Bone Marrow Niche Cells by Repressing Osteopontin Expression.
Title: Snai2 Maintains Bone Marrow Niche Cells by Repressing Osteopontin Expression.
Slug regulates the Dll4-Notch-VEGFR2 axis to control endothelial cell activation and angiogenesis.
Title: Slug regulates the Dll4-Notch-VEGFR2 axis to control endothelial cell activation and angiogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (82)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (7) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SNAI2 (e-PCR)
- UniSTS:504332

Snai2 (e-PCR), detects polymorphism
- UniSTS:516413

Snai2 (e-PCR), detects polymorphism
- UniSTS:547652

Snai2 (e-PCR), detects polymorphism
- UniSTS:527560

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IGI Inferred from Genetic Interaction more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables E-box binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cartilage morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell migration involved in endocardial cushion formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to epidermal growth factor stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to ionizing radiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to platelet-derived growth factor stimulus	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within_positive_effect chromatin organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in desmosome disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in desmosome disassembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epithelial cell migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within epithelial to mesenchymal transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial to mesenchymal transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial to mesenchymal transition involved in endocardial cushion formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelium development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of hematopoietic stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of myeloid cell apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of anoikis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell adhesion involved in substrate-bound cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of hematopoietic stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of keratinocyte proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of myeloid cell apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vitamin D biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vitamin D receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in neural crest cell development	ISO Inferred from Sequence Orthology more info
involved_in pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pigmentation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell chemotaxis	IC Inferred by Curator more info	PubMed
acts_upstream_of_or_within positive regulation of fat cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of apoptotic process	IC Inferred by Curator more info	PubMed
involved_in regulation of bicellular tight junction assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of branching involved in salivary gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of chemokine production	ISO Inferred from Sequence Orthology more info
involved_in regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to radiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to radiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within roof of mouth development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within roof of mouth development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of sound	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within substrate-dependent cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of white fat cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of white fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within white fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing, spreading of cells	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of chromatin	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc finger protein SNAI2

Names: neural crest transcription factor Slug; protein snail homolog 2; slug, chicken homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011415.3 → NP_035545.1 zinc finger protein SNAI2

See identical proteins and their annotated locations for NP_035545.1

Status: VALIDATED

Source sequence(s)

AK133968, BC062164

Consensus CDS

CCDS27974.1

UniProtKB/Swiss-Prot

O09096, P97469, Q9R211

UniProtKB/TrEMBL

Q3UZ96

Related

ENSMUSP00000023356.7, ENSMUST00000023356.8

Conserved Domains (4) summary

sd00017
Location:188 → 208

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00019
Location:131 → 151

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:214 → 236

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:201 → 224

zf-H2C2_2; Zinc-finger double domain