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Snrpe small nuclear ribonucleoprotein E [ Mus musculus (house mouse) ]

Gene ID: 20643, updated on 4-Jan-2025

Summary

Official Symbol
Snrpeprovided by MGI
Official Full Name
small nuclear ribonucleoprotein Eprovided by MGI
Primary source
MGI:MGI:98346
See related
Ensembl:ENSMUSG00000090553 AllianceGenome:MGI:98346
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SME; sm-E; snRNP-E
Summary
Predicted to enable U1 snRNP binding activity. Predicted to be involved in spliceosomal snRNP assembly. Predicted to be located in cytosol and nucleus. Predicted to be part of several cellular components, including methylosome; small nuclear ribonucleoprotein complex; and spliceosomal complex. Is expressed in central nervous system; sensory organ; and tooth. Human ortholog(s) of this gene implicated in hepatocellular carcinoma; hypotrichosis 1; hypotrichosis 11; and lupus nephritis. Orthologous to human SNRPE (small nuclear ribonucleoprotein polypeptide E). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in CNS E11.5 (RPKM 136.5), liver E14 (RPKM 135.9) and 19 other tissues See more
Orthologs
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Genomic context

See Snrpe in Genome Data Viewer
Location:
1 E4; 1 57.94 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (133531609..133538018, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (133603871..133610280, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7A pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:135446523-135446815 Neighboring gene STARR-seq mESC enhancer starr_02294 Neighboring gene predicted gene, 23939 Neighboring gene predicted gene, 53475 Neighboring gene zinc finger CCCH type containing 11A Neighboring gene zinc finger, BED type containing 6 Neighboring gene STARR-seq mESC enhancer starr_02296 Neighboring gene STARR-seq mESC enhancer starr_02297 Neighboring gene STARR-seq mESC enhancer starr_02298 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:135586656-135586812 Neighboring gene lymphocyte transmembrane adaptor 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding  
enables U1 snRNP binding  
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome  
involved_in mRNA splicing, via spliceosome  
involved_in spliceosomal snRNP assembly  
involved_in spliceosomal snRNP assembly  
involved_in spliceosomal snRNP assembly  
Items 1 - 20 of 37
Component Evidence Code Pubs
part_of SMN-Sm protein complex  
part_of SMN-Sm protein complex  
part_of U1 snRNP  
part_of U1 snRNP  
part_of U1 snRNP  
part_of U12-type spliceosomal complex  
part_of U12-type spliceosomal complex  
part_of U2 snRNP  
part_of U2-type catalytic step 2 spliceosome  
part_of U2-type catalytic step 2 spliceosome  
part_of U2-type precatalytic spliceosome  
part_of U2-type precatalytic spliceosome  
part_of U2-type spliceosomal complex  
part_of U2-type spliceosomal complex  
part_of U4 snRNP  
part_of U4 snRNP  
part_of U4 snRNP  
part_of U4/U6 x U5 tri-snRNP complex  
part_of U4/U6 x U5 tri-snRNP complex  
part_of U4/U6 x U5 tri-snRNP complex  
part_of U5 snRNP  
part_of U7 snRNP  
part_of U7 snRNP  
part_of catalytic step 2 spliceosome  
located_in cytosol  
located_in cytosol  
part_of methylosome  
part_of methylosome  
located_in nucleus  
located_in nucleus  
part_of pICln-Sm protein complex  
part_of pICln-Sm protein complex  
part_of pICln-Sm protein complex  
part_of precatalytic spliceosome  
part_of spliceosomal complex  
part_of telomerase holoenzyme complex  
part_of telomerase holoenzyme complex  
Items 1 - 20 of 37

General protein information

Preferred Names
small nuclear ribonucleoprotein E
Names
sm protein E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009227.3NP_033253.1  small nuclear ribonucleoprotein E

    See identical proteins and their annotated locations for NP_033253.1

    Status: VALIDATED

    Source sequence(s)
    AW492281, BY168551
    Consensus CDS
    CCDS48364.1
    UniProtKB/Swiss-Prot
    P62305
    UniProtKB/TrEMBL
    E9Q4F4
    Related
    ENSMUSP00000128400.2, ENSMUST00000166915.8
    Conserved Domains (1) summary
    cd01718
    Location:1189
    Sm_E; Sm protein E

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    133531609..133538018 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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