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Plk4 polo like kinase 4 [ Mus musculus (house mouse) ]

Gene ID: 20873, updated on 18-Apr-2024

Summary

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Official Symbol
Plk4provided by MGI
Official Full Name
polo like kinase 4provided by MGI
Primary source
MGI:MGI:101783
See related
Ensembl:ENSMUSG00000025758 AllianceGenome:MGI:101783
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sak; Stk18; 1700028H20
Summary
This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to the nucleolus during G2, to centrosomes during G2/M, and to the cleavage furrow during cytokinesis. It is required for progression through mitosis, cell survival, and embryonic development. The mouse genome contains a pseudogene similar to this gene. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Expression
Broad expression in CNS E11.5 (RPKM 11.4), liver E14 (RPKM 9.6) and 16 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 B; 3 19.54 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (40754463..40771318)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (40799951..40816883)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 Neighboring gene heat shock protein 4 like Neighboring gene STARR-seq mESC enhancer starr_07472 Neighboring gene STARR-positive B cell enhancer ABC_E9547 Neighboring gene major facilitator superfamily domain containing 8 Neighboring gene STARR-positive B cell enhancer ABC_E1617 Neighboring gene predicted gene 2011 Neighboring gene FUN14 domain containing 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Global cellular response to chemical perturbation of PLK4 activity and abnormal centrosome number. Tkach JM, et al. Elife, 2022 Jun 27. PMID 35758262, Free PMC Article
  2. PLK4 is essential for meiotic resumption in mouse oocytes. Luo YB, et al. Biol Reprod, 2015 Apr. PMID 25740542
  3. Spindle formation in the mouse embryo requires Plk4 in the absence of centrioles. Coelho PA, et al. Dev Cell, 2013 Dec 9. PMID 24268700, Free PMC Article
  4. Polo-like kinase 4 kinase activity limits centrosome overduplication by autoregulating its own stability. Holland AJ, et al. J Cell Biol, 2010 Jan 25. PMID 20100909, Free PMC Article
  5. Gene expression patterns in heterozygous Plk4 murine embryonic fibroblasts. Morettin A, et al. BMC Genomics, 2009 Jul 16. PMID 19607708, Free PMC Article

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibition of PLK4 remodels histone methylation and activates the immune response via the cGAS-STING pathway in TP53-mutated AML.
    Title: Inhibition of PLK4 remodels histone methylation and activates the immune response via the cGAS-STING pathway in TP53-mutated AML.
  2. Expression Analyses of Polo-Like Kinase 4, a Gene Product Responsible for Autosomal Recessive Microcephaly and Seckel Syndrome, during Mouse Brain Development.
    Title: Expression Analyses of Polo-Like Kinase 4, a Gene Product Responsible for Autosomal Recessive Microcephaly and Seckel Syndrome, during Mouse Brain Development.
  3. Upstream open reading frames control PLK4 translation and centriole duplication in primordial germ cells.
    Title: Upstream open reading frames control PLK4 translation and centriole duplication in primordial germ cells.
  4. Global cellular response to chemical perturbation of PLK4 activity and abnormal centrosome number.
    Title: Global cellular response to chemical perturbation of PLK4 activity and abnormal centrosome number.
  5. Aurora A and Plk4 are rate-limiting factors contributing to microtubule growth as the acentriolar oocyte resumes meiosis.
    Title: Plk4 and Aurora A cooperate in the initiation of acentriolar spindle assembly in mammalian oocytes.
  6. that aneuploidy induced by transient centrosome amplification can accelerate tumorigenesis in p53-deficient cells
    Title: Transient PLK4 overexpression accelerates tumorigenesis in p53-deficient epidermis.
  7. Transient knockdown of KLF14 is sufficient to induce Plk4-directed centrosome amplification.
    Title: Loss of KLF14 triggers centrosome amplification and tumorigenesis.
  8. PLK4 is essential for meiotic resumption but may not influence spindle formation in mouse oocytes during meiotic maturation
    Title: PLK4 is essential for meiotic resumption in mouse oocytes.
  9. p53-Dependent and cell specific epigenetic regulation of the polo-like kinases under oxidative stress.
    Title: p53-Dependent and cell specific epigenetic regulation of the polo-like kinases under oxidative stress.
  10. The Plk4-Cep152 complex has an unexpected role in promoting microtubule nucleation in the vicinity of chromosomes to mediate bipolar spindle formation in the absence of centrioles.
    Title: Spindle formation in the mouse embryo requires Plk4 in the absence of centrioles.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in centriole replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in centriole replication ISO
Inferred from Sequence Orthology
more info
  
involved_in centriole replication NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in de novo centriole assembly involved in multi-ciliated epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of centriole replication ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in positive regulation of centriole replication ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in trophoblast giant cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in XY body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in deuterosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in procentriole ISO
Inferred from Sequence Orthology
more info
  
part_of procentriole replication complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase PLK4
Names
serine/threonine kinase 18
serine/threonine-protein kinase 18
serine/threonine-protein kinase Sak
NP_001397550.1
NP_001397551.1
NP_035625.2
NP_775261.2
XP_006500833.1
XP_030108378.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410621.1 → NP_001397550.1  serine/threonine-protein kinase PLK4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC160757

  2. NM_001410622.1 → NP_001397551.1  serine/threonine-protein kinase PLK4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC160757

  3. NM_011495.3 → NP_035625.2  serine/threonine-protein kinase PLK4 isoform 1

    See identical proteins and their annotated locations for NP_035625.2

    Status: VALIDATED

    Source sequence(s)
    AC160757
    Consensus CDS
    CCDS17328.1
    UniProtKB/Swiss-Prot
    Q3UVA3, Q64702, Q6PEP6, Q78EG6, Q80UT6, Q8R0I5, Q9CVR6, Q9CVU6
    UniProtKB/TrEMBL
    E9PVH4
    Related
    ENSMUSP00000026858.6, ENSMUST00000026858.11
    Conserved Domains (5) summary
    smart00220
    Location:12 → 265
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13114
    Location:548 → 659
    POLO_box_Plk4_1; First (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
    cd13115
    Location:660 → 768
    POLO_box_Plk4_2; Second (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
    cd13116
    Location:839 → 918
    POLO_box_Plk4_3; C-terminal (third) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
    cd14186
    Location:10 → 265
    STKc_PLK4; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 4

  4. NM_173169.3 → NP_775261.2  serine/threonine-protein kinase PLK4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC160757
    Consensus CDS
    CCDS57210.1
    UniProtKB/TrEMBL
    E9PVH4
    Related
    ENSMUSP00000145277.2, ENSMUST00000203295.3
    Conserved Domains (5) summary
    smart00220
    Location:12 → 265
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13114
    Location:548 → 632
    POLO_box_Plk4_1; First (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
    cd13115
    Location:633 → 741
    POLO_box_Plk4_2; Second (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
    cd13116
    Location:812 → 891
    POLO_box_Plk4_3; C-terminal (third) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
    cd14186
    Location:10 → 265
    STKc_PLK4; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 4

RNA

  1. NR_045576.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC160757
    Related
    ENSMUST00000203895.3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    40754463..40771318
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500770.5 → XP_006500833.1  serine/threonine-protein kinase PLK4 isoform X2

    Conserved Domains (3) summary
    cd13114
    Location:122 → 233
    POLO_box_Plk4_1; First (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
    cd13115
    Location:234 → 342
    POLO_box_Plk4_2; Second (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
    cd13116
    Location:413 → 492
    POLO_box_Plk4_3; C-terminal (third) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)

  2. XM_030252518.2 → XP_030108378.1  serine/threonine-protein kinase PLK4 isoform X2

    Conserved Domains (3) summary
    cd13114
    Location:122 → 233
    POLO_box_Plk4_1; First (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
    cd13115
    Location:234 → 342
    POLO_box_Plk4_2; Second (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
    cd13116
    Location:413 → 492
    POLO_box_Plk4_3; C-terminal (third) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64702.2 GenPept UniProtKB/Swiss-Prot:Q64702

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