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Daam1 dishevelled associated activator of morphogenesis 1 [ Mus musculus (house mouse) ]

Gene ID: 208846, updated on 3-Apr-2024

Summary

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Official Symbol
Daam1provided by MGI
Official Full Name
dishevelled associated activator of morphogenesis 1provided by MGI
Primary source
MGI:MGI:1914596
See related
Ensembl:ENSMUSG00000034574 AllianceGenome:MGI:1914596
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in actin cytoskeleton organization. Predicted to act upstream of or within Wnt signaling pathway. Located in stress fiber. Is expressed in several structures, including central nervous system; embryo mesenchyme; eye; genitourinary system; and gut. Used to study intrinsic cardiomyopathy. Orthologous to human DAAM1 (dishevelled associated activator of morphogenesis 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 12.5), whole brain E14.5 (RPKM 8.6) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Daam1 in Genome Data Viewer
Location:
12 30.06 cM; 12 C3
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (71877834..72039150)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (71830950..71992376)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9630002D21 gene Neighboring gene STARR-seq mESC enhancer starr_32425 Neighboring gene predicted gene, 46356 Neighboring gene STARR-seq mESC enhancer starr_32426 Neighboring gene STARR-seq mESC enhancer starr_32427 Neighboring gene UPF0538 protein C2orf76 homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_32428 Neighboring gene STARR-positive B cell enhancer ABC_E5334 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_32431 Neighboring gene predicted gene, 53214 Neighboring gene predicted gene, 40440

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. DAAM1 stabilizes epithelial junctions by restraining WAVE complex-dependent lateral membrane motility. Nishimura T, et al. J Cell Biol, 2016 Nov 21. PMID 27807130, Free PMC Article
  2. Localization of the Diaphanous-related formin Daam1 to neuronal dendrites. Salomon SN, et al. Neurosci Lett, 2008 Dec 5. PMID 18832009
  3. Formin DAAM1 Organizes Actin Filaments in the Cytoplasmic Nodal Actin Network. Luo W, et al. PLoS One, 2016. PMID 27760153, Free PMC Article
  4. The formin Daam1 and fascin directly collaborate to promote filopodia formation. Jaiswal R, et al. Curr Biol, 2013 Jul 22. PMID 23850281, Free PMC Article
  5. WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion. Rodriguez-Hernandez I, et al. Nat Commun, 2020 Oct 20. PMID 33082334, Free PMC Article

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion.
    Title: WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion.
  2. we generated Daam-deficient mice by gene targeting and found that Daam1, but not Daam2, is necessary for fetal survival. Embryonic development of Daam1 mutants was delayed most likely due to functional defects in the labyrinthine layer of the placenta. Examination of Daam2 and Daam1/2 double mutants revealed that Daam1 and Daam2 are functionally redundant during placental development.
    Title: Placental defects lead to embryonic lethality in mice lacking the Formin and PCP proteins Daam1 and Daam2.
  3. MTSS1's C terminus binds to DAAM1 and paused DAAM1-mediated F-actin polymerization.
    Title: MTSS1 Regulation of Actin-Nucleating Formin DAAM1 in Dendritic Filopodia Determines Final Dendritic Configuration of Purkinje Cells.
  4. The data suggested that Daam1 affected actin assembly during oocyte meiotic division via the regulation of fascin expression.
    Title: Daam1 regulates fascin for actin assembly in mouse oocyte meiosis.
  5. DAAM1 organizes actin filaments into a nodal complex
    Title: Formin DAAM1 Organizes Actin Filaments in the Cytoplasmic Nodal Actin Network.
  6. DAAM1 loss evokes invasive abilities of epithelial cells.
    Title: DAAM1 stabilizes epithelial junctions by restraining WAVE complex-dependent lateral membrane motility.
  7. Daam1 knockout mice that were also homozygous for Daam2 had stronger noncompaction cardiomyopathy, severely reduced cardiac function, disrupted sarcomere structure, and increased myocardial proliferation.
    Title: DAAM1 and DAAM2 are co-required for myocardial maturation and sarcomere assembly.
  8. Fascin and Daam1 coimmunoprecipitated from cell extracts, and silencing of fascin led to a striking loss of Daam1 localization to filopodial shafts. Purified fascin bound directly to Daam1; fascin recruited Daam1 to and stabilized Daam1 on actin bundles.
    Title: The formin Daam1 and fascin directly collaborate to promote filopodia formation.
  9. Daam1 is important for regulating filamentous actin assembly and organization, and consequently for cytoskeletal function in cardiomyocytes, which contributes to proper heart morphogenesis.
    Title: Dishevelled-associated activator of morphogenesis 1 (Daam1) is required for heart morphogenesis.
  10. a carboxyl-terminal binding partner, Dvl, has a role in activation of Daam1
    Title: Mechanism of activation of the Formin protein Daam1.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • mKIAA0666, E130308H01, 1700066F09Rik, 2310028E21Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular component organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in motile cilium ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in stress fiber IDA
Inferred from Direct Assay
more info
 PubMed 
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
disheveled-associated activator of morphogenesis 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286452.1 → NP_001273381.1  disheveled-associated activator of morphogenesis 1 isoform b

    See identical proteins and their annotated locations for NP_001273381.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (b) is shorter, compared to isoform a.
    Source sequence(s)
    AC159186, AK033683, AK147480, AK162231, BC076585
    Consensus CDS
    CCDS88349.1
    UniProtKB/TrEMBL
    Q6ZQ74
    Related
    ENSMUSP00000152532.2, ENSMUST00000221317.2
    Conserved Domains (4) summary
    PRK12704
    Location:444 → 513
    PRK12704; phosphodiesterase; Provisional
    pfam02181
    Location:600 → 973
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:235 → 439
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:45 → 232
    Drf_GBD; Diaphanous GTPase-binding Domain

  2. NM_001422845.1 → NP_001409774.1  disheveled-associated activator of morphogenesis 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC124356, AC159186

  3. NM_001422846.1 → NP_001409775.1  disheveled-associated activator of morphogenesis 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC124356, AC159186

  4. NM_026102.3 → NP_080378.2  disheveled-associated activator of morphogenesis 1 isoform a

    See identical proteins and their annotated locations for NP_080378.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC124356, AK033683, AK162231, BC076585, CD352113
    Consensus CDS
    CCDS25964.1
    UniProtKB/Swiss-Prot
    Q3UHB4, Q6DFY0, Q6TAB8, Q80Y68, Q8BPM0, Q9CQQ2
    UniProtKB/TrEMBL
    Q6ZQ74
    Related
    ENSMUSP00000082406.3, ENSMUST00000085299.4
    Conserved Domains (4) summary
    PRK12704
    Location:444 → 513
    PRK12704; phosphodiesterase; Provisional
    pfam06367
    Location:235 → 439
    Drf_FH3; Diaphanous FH3 Domain
    pfam02181
    Location:600 → 982
    FH2; Formin Homology 2 Domain
    pfam06371
    Location:45 → 232
    Drf_GBD; Diaphanous GTPase-binding Domain

  5. NM_172464.3 → NP_766052.2  disheveled-associated activator of morphogenesis 1 isoform a

    See identical proteins and their annotated locations for NP_766052.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC124356, AK033683, AK162231, BC076585
    Consensus CDS
    CCDS25964.1
    UniProtKB/Swiss-Prot
    Q3UHB4, Q6DFY0, Q6TAB8, Q80Y68, Q8BPM0, Q9CQQ2
    UniProtKB/TrEMBL
    Q6ZQ74
    Related
    ENSMUSP00000152564.2, ENSMUST00000223272.2
    Conserved Domains (4) summary
    PRK12704
    Location:444 → 513
    PRK12704; phosphodiesterase; Provisional
    pfam06367
    Location:235 → 439
    Drf_FH3; Diaphanous FH3 Domain
    pfam02181
    Location:600 → 982
    FH2; Formin Homology 2 Domain
    pfam06371
    Location:45 → 232
    Drf_GBD; Diaphanous GTPase-binding Domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    71877834..72039150
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246636.1 → XP_030102496.1  disheveled-associated activator of morphogenesis 1 isoform X1

    UniProtKB/Swiss-Prot
    Q3UHB4, Q6DFY0, Q6TAB8, Q80Y68, Q8BPM0, Q9CQQ2
    UniProtKB/TrEMBL
    Q6ZQ74
    Conserved Domains (4) summary
    PRK12704
    Location:444 → 513
    PRK12704; phosphodiesterase; Provisional
    pfam06367
    Location:235 → 439
    Drf_FH3; Diaphanous FH3 Domain
    pfam02181
    Location:600 → 982
    FH2; Formin Homology 2 Domain
    pfam06371
    Location:45 → 232
    Drf_GBD; Diaphanous GTPase-binding Domain

  2. XM_036157296.1 → XP_036013189.1  disheveled-associated activator of morphogenesis 1 isoform X1

    UniProtKB/Swiss-Prot
    Q3UHB4, Q6DFY0, Q6TAB8, Q80Y68, Q8BPM0, Q9CQQ2
    UniProtKB/TrEMBL
    Q6ZQ74
    Conserved Domains (4) summary
    PRK12704
    Location:444 → 513
    PRK12704; phosphodiesterase; Provisional
    pfam06367
    Location:235 → 439
    Drf_FH3; Diaphanous FH3 Domain
    pfam02181
    Location:600 → 982
    FH2; Formin Homology 2 Domain
    pfam06371
    Location:45 → 232
    Drf_GBD; Diaphanous GTPase-binding Domain

  3. XM_036157297.1 → XP_036013190.1  disheveled-associated activator of morphogenesis 1 isoform X1

    UniProtKB/Swiss-Prot
    Q3UHB4, Q6DFY0, Q6TAB8, Q80Y68, Q8BPM0, Q9CQQ2
    UniProtKB/TrEMBL
    Q6ZQ74
    Conserved Domains (4) summary
    PRK12704
    Location:444 → 513
    PRK12704; phosphodiesterase; Provisional
    pfam06367
    Location:235 → 439
    Drf_FH3; Diaphanous FH3 Domain
    pfam02181
    Location:600 → 982
    FH2; Formin Homology 2 Domain
    pfam06371
    Location:45 → 232
    Drf_GBD; Diaphanous GTPase-binding Domain

  4. XM_006515642.4 → XP_006515705.1  disheveled-associated activator of morphogenesis 1 isoform X1

    See identical proteins and their annotated locations for XP_006515705.1

    UniProtKB/Swiss-Prot
    Q3UHB4, Q6DFY0, Q6TAB8, Q80Y68, Q8BPM0, Q9CQQ2
    UniProtKB/TrEMBL
    Q6ZQ74
    Conserved Domains (4) summary
    PRK12704
    Location:444 → 513
    PRK12704; phosphodiesterase; Provisional
    pfam06367
    Location:235 → 439
    Drf_FH3; Diaphanous FH3 Domain
    pfam02181
    Location:600 → 982
    FH2; Formin Homology 2 Domain
    pfam06371
    Location:45 → 232
    Drf_GBD; Diaphanous GTPase-binding Domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BPM0.4 GenPept UniProtKB/Swiss-Prot:Q8BPM0

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