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Ncoa7 nuclear receptor coactivator 7 [ Mus musculus (house mouse) ]

Gene ID: 211329, updated on 11-Apr-2024

Summary

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Official Symbol
Ncoa7provided by MGI
Official Full Name
nuclear receptor coactivator 7provided by MGI
Primary source
MGI:MGI:2444847
See related
Ensembl:ENSMUSG00000039697 AllianceGenome:MGI:2444847
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9030406N13Rik
Summary
Predicted to enable nuclear receptor binding activity and nuclear receptor coactivator activity. Acts upstream of or within negative regulation of cellular response to oxidative stress; negative regulation of oxidative stress-induced neuron death; and negative regulation of peptidyl-cysteine S-nitrosylation. Predicted to be active in nucleus. Is expressed in several structures, including adipose tissue; brain; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human NCOA7 (nuclear receptor coactivator 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 9.0), cortex adult (RPKM 6.3) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 A4; 10 17.11 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (30521578..30683401, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (30645582..30807700, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene tRNA methyltransferase 11 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:30320514-30320623 Neighboring gene STARR-positive B cell enhancer ABC_E6828 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:30338273-30338456 Neighboring gene predicted gene, 20300 Neighboring gene STARR-seq mESC enhancer starr_26197 Neighboring gene histidine triad nucleotide binding protein 3 Neighboring gene STARR-seq mESC enhancer starr_26199 Neighboring gene STARR-seq mESC enhancer starr_26200 Neighboring gene STARR-positive B cell enhancer ABC_E5123 Neighboring gene STARR-seq mESC enhancer starr_26202 Neighboring gene non-POU-domain-containing, octamer binding protein pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8861 Neighboring gene STARR-seq mESC enhancer starr_26204 Neighboring gene nuclear encoded tRNA glutamic acid 9 (anticodon CTC) Neighboring gene predicted gene, 30618

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Engagement of Nuclear Coactivator 7 by 3-Hydroxyanthranilic Acid Enhances Activation of Aryl Hydrocarbon Receptor in Immunoregulatory Dendritic Cells. Gargaro M, et al. Front Immunol, 2019. PMID 31481962, Free PMC Article
  2. Targeted deletion of the Ncoa7 gene results in incomplete distal renal tubular acidosis in mice. Merkulova M, et al. Am J Physiol Renal Physiol, 2018 Jul 1. PMID 29384414, Free PMC Article
  3. Interaction of Estrogen Receptor Associated Protein (ERAP) 140 with ER beta decreases but its expression increases in aging mouse cerebral cortex. Paramanik V, et al. Cell Mol Neurobiol, 2010 Aug. PMID 20446107
  4. Molecular characterization and bioinformatics analysis of Ncoa7B, a novel ovulation-associated and reproduction system-specific Ncoa7 isoform. Shkolnik K, et al. Reproduction, 2008 Mar. PMID 18299425
  5. Expression of Hey2 transcription factor in the early embryonic ventricles is controlled through a distal enhancer by Tbx20 and Gata transcription factors. Ihara D, et al. Dev Biol, 2020 May 15. PMID 32035085

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NCOA7 Regulates Growth and Metastasis of Clear Cell Renal Cell Carcinoma via MAPK/ERK Signaling Pathway.
    Title: NCOA7 Regulates Growth and Metastasis of Clear Cell Renal Cell Carcinoma via MAPK/ERK Signaling Pathway.
  2. The Ncoa7 locus regulates V-ATPase formation and function, neurodevelopment and behaviour.
    Title: The Ncoa7 locus regulates V-ATPase formation and function, neurodevelopment and behaviour.
  3. Engagement of Nuclear Coactivator 7 by 3-Hydroxyanthranilic Acid Enhances Activation of Aryl Hydrocarbon Receptor in Immunoregulatory Dendritic Cells.
    Title: Engagement of Nuclear Coactivator 7 by 3-Hydroxyanthranilic Acid Enhances Activation of Aryl Hydrocarbon Receptor in Immunoregulatory Dendritic Cells.
  4. Ncoa7 is involved in collecting duct intercalated cells function and urine acidification in mice in vivo, likely through modulating the abundance of V-ATPase and other key acid-base regulators in the renal medulla.
    Title: Targeted deletion of the Ncoa7 gene results in incomplete distal renal tubular acidosis in mice.
  5. ERAP 140 interacts with ER beta and its interaction decreases but its expression increases with age in mouse cerebral cortex.
    Title: Interaction of Estrogen Receptor Associated Protein (ERAP) 140 with ER beta decreases but its expression increases in aging mouse cerebral cortex.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (6)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nuclear receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear receptor coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of cellular response to oxidative stress IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of peptidyl-cysteine S-nitrosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
nuclear receptor coactivator 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111267.2 → NP_001104737.1  nuclear receptor coactivator 7 isoform 2

    See identical proteins and their annotated locations for NP_001104737.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different segment for its 5' coding region and 5' UTR, and lacks much of the 5' coding region, compared to variant 1. The resulting protein (isoform 2) has a distinct and shorter N-terminus when it is compared to isoform 1.
    Source sequence(s)
    BC080742, EF602028
    Consensus CDS
    CCDS48530.1
    UniProtKB/TrEMBL
    A9Q6S9
    Related
    ENSMUSP00000150981.2, ENSMUST00000216172.2
    Conserved Domains (1) summary
    smart00584
    Location:59 → 221
    TLDc; domain in TBC and LysM domain containing proteins

  2. NM_001358841.1 → NP_001345770.1  nuclear receptor coactivator 7 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC125532, BB870337, BC076623, BC080742, CV556753
    Consensus CDS
    CCDS87979.1
    UniProtKB/TrEMBL
    B9EIW5
    Related
    ENSMUSP00000149957.2, ENSMUST00000213836.2
    Conserved Domains (2) summary
    smart00584
    Location:770 → 932
    TLDc; domain in TBC and LysM domain containing proteins
    pfam01476
    Location:119 → 161
    LysM; LysM domain

  3. NM_001358842.1 → NP_001345771.1  nuclear receptor coactivator 7 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC125532, BB870337, BC076623, BC080742
    Consensus CDS
    CCDS87978.1
    UniProtKB/TrEMBL
    A0A1L1SSS4
    Related
    ENSMUSP00000150021.2, ENSMUST00000215926.2
    Conserved Domains (2) summary
    smart00584
    Location:732 → 894
    TLDc; domain in TBC and LysM domain containing proteins
    pfam01476
    Location:119 → 156
    LysM; LysM domain

  4. NM_172495.6 → NP_766083.3  nuclear receptor coactivator 7 isoform 1

    See identical proteins and their annotated locations for NP_766083.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
    Source sequence(s)
    AC125532, BB870337, BC076623, BC080742
    Consensus CDS
    CCDS23765.1
    UniProtKB/Swiss-Prot
    Q3TAR1, Q3UNB3, Q66K05, Q6DFV7, Q6ZQM4, Q8BJ15, Q8BJ39
    Related
    ENSMUSP00000066741.5, ENSMUST00000068567.5
    Conserved Domains (3) summary
    smart00584
    Location:781 → 943
    TLDc; domain in TBC and LysM domain containing proteins
    COG1388
    Location:91 → 161
    LysM; LysM repeat [Cell wall/membrane/envelope biogenesis]
    pfam01476
    Location:119 → 161
    LysM; LysM domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    30521578..30683401 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243155.4 → XP_011241457.1  nuclear receptor coactivator 7 isoform X3

    Conserved Domains (2) summary
    smart00584
    Location:791 → 883
    TLDc; domain in TBC and LysM domain containing proteins
    pfam01476
    Location:119 → 161
    LysM; LysM domain

  2. XM_011243153.4 → XP_011241455.1  nuclear receptor coactivator 7 isoform X1

    Conserved Domains (2) summary
    smart00584
    Location:791 → 953
    TLDc; domain in TBC and LysM domain containing proteins
    pfam01476
    Location:119 → 161
    LysM; LysM domain

  3. XM_011243154.4 → XP_011241456.1  nuclear receptor coactivator 7 isoform X2

    Conserved Domains (2) summary
    smart00584
    Location:780 → 942
    TLDc; domain in TBC and LysM domain containing proteins
    pfam01476
    Location:119 → 161
    LysM; LysM domain

  4. XM_036155720.1 → XP_036011613.1  nuclear receptor coactivator 7 isoform X4

    Conserved Domains (2) summary
    smart00584
    Location:781 → 873
    TLDc; domain in TBC and LysM domain containing proteins
    pfam01476
    Location:119 → 161
    LysM; LysM domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6DFV7.2 GenPept UniProtKB/Swiss-Prot:Q6DFV7

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