Tcf7 transcription factor 7, T cell specific [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tcf7provided by MGI
Official Full Name: transcription factor 7, T cell specificprovided by MGI
Primary source: MGI:MGI:98507
See related: Ensembl:ENSMUSG00000000782 AllianceGenome:MGI:98507
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tcf1; TCF-1
Summary: This gene encodes a transcription factor which is a member of the T-cell specific transcription factor family. The encoded protein is distinct from the hepatic transcription factor, transcription factor 1, which is also referred to by the symbol Tcf1. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Sep 2015]
Expression: Biased expression in thymus adult (RPKM 829.6) and spleen adult (RPKM 56.0) See more
Orthologs: human all
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Genomic context

Location:: 11 B1.3; 11 31.86 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (52137347..52174211, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (52246527..52283383, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Downregulation of TCF7 and LEF1 is a key determinant of tumor-infiltrating regulatory T-cell function.
Title: Downregulation of TCF7 and LEF1 is a key determinant of tumor-infiltrating regulatory T-cell function.
Effector-Phase IL-2 Signals Drive Th1 Effector and Memory Responses Dependently and Independently of TCF-1.
Title: Effector-Phase IL-2 Signals Drive Th1 Effector and Memory Responses Dependently and Independently of TCF-1.
TCF-1 limits intraepithelial lymphocyte antitumor immunity in colorectal carcinoma.
Title: TCF-1 limits intraepithelial lymphocyte antitumor immunity in colorectal carcinoma.
TCF7 and LEF-1 downregulation in sepsis promotes immune suppression by inhibiting CD4[+] T cell proliferation.
Title: TCF7 and LEF-1 downregulation in sepsis promotes immune suppression by inhibiting CD4(+) T cell proliferation.
Transcription factor TCF-1 regulates the functions, but not the development, of lymphoid tissue inducer subsets in different tissues.
Title: Transcription factor TCF-1 regulates the functions, but not the development, of lymphoid tissue inducer subsets in different tissues.
TCF-1 regulates NKG2D expression on CD8 T cells during anti-tumor responses.
Title: TCF-1 regulates NKG2D expression on CD8 T cells during anti-tumor responses.
The Chromatin Regulator Mll1 Supports T Follicular Helper Cell Differentiation by Controlling Expression of Bcl6, LEF-1, and TCF-1.
Title: The Chromatin Regulator Mll1 Supports T Follicular Helper Cell Differentiation by Controlling Expression of Bcl6, LEF-1, and TCF-1.
CD4[+] T cell memory is impaired by species-specific cytotoxic differentiation, but not by TCF-1 loss.
Title: CD4(+) T cell memory is impaired by species-specific cytotoxic differentiation, but not by TCF-1 loss.
TCF-1 negatively regulates the suppressive ability of canonical and noncanonical Tregs.
Title: TCF-1 negatively regulates the suppressive ability of canonical and noncanonical Tregs.
TCF-1 Is Required for CD4 T Cell Persistence Functions during AlloImmunity.
Title: TCF-1 Is Required for CD4 T Cell Persistence Functions during AlloImmunity.

Submit: New GeneRIF Correction See all GeneRIFs (102)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (9) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tcf7 (e-PCR), detects polymorphism
- UniSTS:498451

PMC316557P1 (e-PCR)
- UniSTS:273005

Tcf7 (e-PCR), detects polymorphism
- UniSTS:463226

X61385 (e-PCR)
- UniSTS:125823

Tcf7 (e-PCR), detects polymorphism
- UniSTS:507274

Tcf7 (e-PCR), detects polymorphism
- UniSTS:499115

PMC126018P1 (e-PCR)
- UniSTS:270518

AI465550 (e-PCR)
- UniSTS:180191

UniSTS:498411 (e-PCR)
- UniSTS:498411

Tcf7 (e-PCR), detects polymorphism
- UniSTS:498411

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell receptor V(D)J recombination	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within alpha-beta T cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in canonical Wnt signaling pathway involved in negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to interleukin-4	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic digestive tract morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic genitalia morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic hindgut morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in gamma-delta T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural tube development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of gamma-delta T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of beta-catenin-TCF complex	IBA Inferred from Biological aspect of Ancestor more info
part_of chromatin	IBA Inferred from Biological aspect of Ancestor more info
part_of euchromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transcription factor 7

Names: T-cell-specific transcription factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001313981.2 → NP_001300910.2 transcription factor 7 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform 1.

Source sequence(s)

AL645862

UniProtKB/TrEMBL

A0A5K1VVQ7
NM_001427422.1 → NP_001414351.1 transcription factor 7 isoform 3

Status: REVIEWED

Source sequence(s)

AL645862
NM_001427423.1 → NP_001414352.1 transcription factor 7 isoform 4

Status: REVIEWED

Source sequence(s)

AL645862
NM_001427424.1 → NP_001414353.1 transcription factor 7 isoform 5

Status: REVIEWED

Source sequence(s)

AL645862
NM_001427425.1 → NP_001414354.1 transcription factor 7 isoform 6

Status: REVIEWED

Source sequence(s)

AL645862
NM_001427426.1 → NP_001414355.1 transcription factor 7 isoform 7

Status: REVIEWED

Source sequence(s)

AL645862
NM_009331.5 → NP_033357.1 transcription factor 7 isoform 2

See identical proteins and their annotated locations for NP_033357.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) encodes isoform 2.

Source sequence(s)

AL645862

Consensus CDS

CCDS24670.1

UniProtKB/TrEMBL

B7ZNN3, Q80UF1

Related

ENSMUSP00000084055.4, ENSMUST00000086844.10

Conserved Domains (2) summary

cd01388
Location:188 → 258

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

pfam08347
Location:1 → 100

CTNNB1_binding; N-terminal CTNNB1 binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

52137347..52174211 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030245766.2 → XP_030101626.1 transcription factor 7 isoform X1

Conserved Domains (2) summary

cd01388
Location:304 → 374

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:20 → 216

CTNNB1_binding; N-terminal CTNNB1 binding
XM_030245769.2 → XP_030101629.1 transcription factor 7 isoform X3

UniProtKB/Swiss-Prot

Q00417

Conserved Domains (2) summary

cd01388
Location:304 → 374

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:20 → 216

CTNNB1_binding; N-terminal CTNNB1 binding
XM_030245773.2 → XP_030101633.1 transcription factor 7 isoform X7

Conserved Domains (1) summary

cd01388
Location:98 → 168

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...