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EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit [ Homo sapiens (human) ]

Gene ID: 2146, updated on 11-Apr-2024

Summary

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Official Symbol
EZH2provided by HGNC
Official Full Name
enhancer of zeste 2 polycomb repressive complex 2 subunitprovided by HGNC
Primary source
HGNC:HGNC:3527
See related
Ensembl:ENSG00000106462 MIM:601573; AllianceGenome:HGNC:3527
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WVS; ENX1; KMT6; WVS2; ENX-1; EZH2b; KMT6A
Summary
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]
Expression
Broad expression in bone marrow (RPKM 9.3), testis (RPKM 8.6) and 14 other tissues See more
Orthologs
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Genomic context

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See EZH2 in Genome Data Viewer
Location:
7q36.1
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (148807383..148884291, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (149989157..150066070, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (148504475..148581383, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene acyl-CoA thioesterase 13 pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr7:148388173-148388399 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18733 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26800 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:148396297-148397022 Neighboring gene cullin 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:148469244-148470443 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26801 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:148479522-148480224 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:148480425-148481624 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:148495129-148496328 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:148504832-148505332 Neighboring gene RNA, U7 small nuclear 20 pseudogene Neighboring gene Sharpr-MPRA regulatory region 2848 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:148580637-148581328 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18737 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18738 Neighboring gene uncharacterized LOC124901767 Neighboring gene RNA, 7SL, cytoplasmic 569, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. EZH2 mediated metabolic rewiring promotes tumor growth independently of histone methyltransferase activity in ovarian cancer. Chen J, et al. Mol Cancer, 2023 May 20. PMID 37210576, Free PMC Article
  2. EZH2 can be used as a therapeutic agent for inhibiting endothelial dysfunction. Sun L, et al. Biochem Pharmacol, 2023 Jul. PMID 37207700
  3. EZH2 regulates pancreatic cancer cells through E2F1, GLI1, CDK3, and Mcm4. Li H, et al. Hereditas, 2023 May 17. PMID 37198697, Free PMC Article
  4. Modulation of EZH2 Activity Induces an Antitumoral Effect and Cell Redifferentiation in Anaplastic Thyroid Cancer. de Mello DC, et al. Int J Mol Sci, 2023 Apr 26. PMID 37175580, Free PMC Article
  5. The roles of EZH2 in cancer and its inhibitors. Liu Y, et al. Med Oncol, 2023 May 6. PMID 37148376, Free PMC Article

See all (1469) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. EZH2-interacting lncRNAs contribute to gastric tumorigenesis; a review on the mechanisms of action.
    Title: EZH2-interacting lncRNAs contribute to gastric tumorigenesis; a review on the mechanisms of action.
  2. MAL expression downregulation through suppressive H3K27me3 marks at the promoter in HPV16-related cervical cancers is prognostically relevant and manifested by the interplay of novel MAL antisense long noncoding RNA AC103563.8, E7 oncoprotein and EZH2.
    Title: MAL expression downregulation through suppressive H3K27me3 marks at the promoter in HPV16-related cervical cancers is prognostically relevant and manifested by the interplay of novel MAL antisense long noncoding RNA AC103563.8, E7 oncoprotein and EZH2.
  3. EZH2-mediated development of therapeutic resistance in cancer.
    Title: EZH2-mediated development of therapeutic resistance in cancer.
  4. EZH2 immunoexpression in pleomorphic adenoma and adenoid cystic carcinoma and clinicopathological features.
    Title: EZH2 immunoexpression in pleomorphic adenoma and adenoid cystic carcinoma and clinicopathological features.
  5. DLEU2/EZH2/GFI1 Axis Regulates the Proliferation and Apoptosis of Human Bone Marrow Mesenchymal Stem Cells.
    Title: DLEU2/EZH2/GFI1 Axis Regulates the Proliferation and Apoptosis of Human Bone Marrow Mesenchymal Stem Cells.
  6. The competitive mechanism of EZH1 and EZH2 in promoting oral squamous cell carcinoma.
    Title: The competitive mechanism of EZH1 and EZH2 in promoting oral squamous cell carcinoma.
  7. Regulation of EZH2 protein stability: new mechanisms, roles in tumorigenesis, and roads to the clinic.
    Title: Regulation of EZH2 protein stability: new mechanisms, roles in tumorigenesis, and roads to the clinic.
  8. Comparative analysis of EZH2, p16 and p53 expression in uterine carcinosarcomas.
    Title: Comparative analysis of EZH2, p16 and p53 expression in uterine carcinosarcomas.
  9. Epigenetic vulnerabilities of leukemia harboring inactivating EZH2 mutations.
    Title: Epigenetic vulnerabilities of leukemia harboring inactivating EZH2 mutations.
  10. HOMER3 promotes liver hepatocellular carcinoma cancer progression by -upregulating EZH2 and mediating miR-361/GPNMB axis.
    Title: HOMER3 promotes liver hepatocellular carcinoma cancer progression by -upregulating EZH2 and mediating miR-361/GPNMB axis.
Submit: New GeneRIF Correction See all GeneRIFs (1330)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Weaver syndrome
MedGen: C0265210 OMIM: 277590 GeneReviews: EZH2-Related Overgrowth
Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Screening in Jurkat T-cells with a short-hairpin-RNA (shRNA) library identifies enhancer of zeste homolog 2 (EZH2) is important for HIV-1 replication PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat induces EZH2 phophorylation in an Akt1 dependent manner PubMed
tat HIV-1 Tat decreases EZH2 levels on the HIV-1 LTR PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC9169

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II core promoter sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H3 methyltransferase activity TAS
Traceable Author Statement
more info
  
enables histone H3K27 methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3K27 methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H3K27 methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables histone H3K27 methyltransferase activity TAS
Traceable Author Statement
more info
 PubMed 
enables histone H3K27 trimethyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables lncRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables primary miRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables promoter-specific chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-lysine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-lysine N-methyltransferase activity TAS
Traceable Author Statement
more info
  
enables ribonucleoprotein complex binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription corepressor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transcription corepressor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in B cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in G1 to G0 transition IEA
Inferred from Electronic Annotation
more info
  
involved_in G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cardiac muscle hypertrophy in response to stress IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to trichostatin A IEA
Inferred from Electronic Annotation
more info
  
involved_in cerebellar cortex development IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin organization TAS
Traceable Author Statement
more info
  
involved_in facultative heterochromatin formation IEA
Inferred from Electronic Annotation
more info
  
involved_in hepatocyte homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hippocampus development IEA
Inferred from Electronic Annotation
more info
  
involved_in keratinocyte differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in liver regeneration IEA
Inferred from Electronic Annotation
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cytokine production involved in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of gene expression, epigenetic IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of gene expression, epigenetic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of gene expression, epigenetic TAS
Traceable Author Statement
more info
  
involved_in negative regulation of keratinocyte differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of retinoic acid receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of stem cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of striated muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription elongation by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell cycle G1/S phase transition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of dendrite development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of epithelial to mesenchymal transition IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization to chromatin IEA
Inferred from Electronic Annotation
more info
  
involved_in protein modification process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
  
involved_in regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of gliogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of kidney development IEA
Inferred from Electronic Annotation
more info
  
involved_in response to estradiol IEA
Inferred from Electronic Annotation
more info
  
involved_in response to tetrachloromethane IEA
Inferred from Electronic Annotation
more info
  
involved_in rhythmic process IEA
Inferred from Electronic Annotation
more info
  
involved_in skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration IEA
Inferred from Electronic Annotation
more info
  
involved_in stem cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in subtelomeric heterochromatin formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in synaptic transmission, GABAergic IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of ESC/E(Z) complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ESC/E(Z) complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
part_of chromatin silencing complex IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, telomeric region IGI
Inferred from Genetic Interaction
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of pericentric heterochromatin IEA
Inferred from Electronic Annotation
more info
  
located_in pronucleus IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
histone-lysine N-methyltransferase EZH2
Names
enhancer of zeste homolog 2
lysine N-methyltransferase 6
NP_001190176.1
NP_001190177.1
NP_001190178.1
NP_004447.2
NP_694543.1
XP_005250019.1
XP_005250020.1
XP_005250021.1
XP_011514185.1
XP_011514187.1
XP_011514189.1
XP_011514191.1
XP_011514192.1
XP_011514194.1
XP_011514195.1
XP_011514196.1
XP_011514197.1
XP_011514198.1
XP_011514201.1
XP_011514203.1
XP_016867306.1
XP_016867308.1
XP_016867309.1
XP_047275945.1
XP_047275946.1
XP_047275947.1
XP_047275948.1
XP_047275949.1
XP_047275950.1
XP_047275951.1
XP_047275952.1
XP_047275953.1
XP_047275954.1
XP_047275955.1
XP_047275956.1
XP_047275957.1
XP_047275958.1
XP_047275960.1
XP_047275961.1
XP_047275962.1
XP_047275963.1
XP_047275964.1
XP_047275965.1
XP_054213455.1
XP_054213456.1
XP_054213457.1
XP_054213458.1
XP_054213459.1
XP_054213460.1
XP_054213461.1
XP_054213462.1
XP_054213463.1
XP_054213464.1
XP_054213465.1
XP_054213466.1
XP_054213467.1
XP_054213468.1
XP_054213469.1
XP_054213470.1
XP_054213471.1
XP_054213472.1
XP_054213473.1
XP_054213474.1
XP_054213475.1
XP_054213476.1
XP_054213477.1
XP_054213478.1
XP_054213479.1
XP_054213480.1
XP_054213481.1
XP_054213482.1
XP_054213483.1
XP_054213484.1
XP_054213485.1
XP_054213486.1
XP_054213487.1
XP_054213488.1
XP_054213489.1
XP_054213490.1
XP_054213491.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032043.1 RefSeqGene

    Range
    5001..81978
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_531

mRNA and Protein(s)

  1. NM_001203247.2 → NP_001190176.1  histone-lysine N-methyltransferase EZH2 isoform c

    See identical proteins and their annotated locations for NP_001190176.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame segment in the coding region, as compared to variant 1. The resulting isoform (c) lacks one internal segment, as compared to isoform a.
    Source sequence(s)
    BC010858, BU953788, CN283479, U61145
    Consensus CDS
    CCDS56516.1
    UniProtKB/Swiss-Prot
    B2RAQ1, B3KS30, B7Z1D6, B7Z7L6, Q15755, Q15910, Q75MG3, Q92857, Q96FI6
    UniProtKB/TrEMBL
    Q75MP9
    Related
    ENSP00000419711.1, ENST00000460911.5
    Conserved Domains (4) summary
    cd19218
    Location:609 → 728
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:39 → 68
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:158 → 249
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:559 → 590
    preSET_CXC; CXC domain

  2. NM_001203248.2 → NP_001190177.1  histone-lysine N-methyltransferase EZH2 isoform d

    See identical proteins and their annotated locations for NP_001190177.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two in-frame segments in the coding region, as compared to variant 1. The resulting isoform (d) lacks two internal segments, as compared to isoform a.
    Source sequence(s)
    AK293239, BC010858, BU953788, CN283479
    Consensus CDS
    CCDS56518.1
    UniProtKB/TrEMBL
    Q75MP9
    Related
    ENSP00000419856.1, ENST00000483967.5
    Conserved Domains (4) summary
    cd19218
    Location:600 → 719
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:39 → 68
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:149 → 240
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:550 → 581
    preSET_CXC; CXC domain

  3. NM_001203249.2 → NP_001190178.1  histone-lysine N-methyltransferase EZH2 isoform e

    See identical proteins and their annotated locations for NP_001190178.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has an alternate 5' UTR exon and lacks an in-frame exon and two in-frame segments in the coding region, as compared to variant 1. The resulting isoform (e) lacks three internal segments, as compared to isoform a.
    Source sequence(s)
    AK302216, BC010858, BU953788
    Consensus CDS
    CCDS56517.1
    UniProtKB/TrEMBL
    Q75MP9
    Related
    ENSP00000419050.1, ENST00000476773.5
    Conserved Domains (4) summary
    cd19218
    Location:558 → 677
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:39 → 68
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:149 → 240
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:508 → 539
    preSET_CXC; CXC domain

  4. NM_004456.5 → NP_004447.2  histone-lysine N-methyltransferase EZH2 isoform a

    See identical proteins and their annotated locations for NP_004447.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    BC010858, BU953788, CN283479
    Consensus CDS
    CCDS5891.1
    UniProtKB/TrEMBL
    A0A090N8E9, Q75MQ0
    Related
    ENSP00000320147.2, ENST00000320356.7
    Conserved Domains (4) summary
    cd19218
    Location:614 → 733
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:39 → 68
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:158 → 249
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:564 → 595
    preSET_CXC; CXC domain

  5. NM_152998.3 → NP_694543.1  histone-lysine N-methyltransferase EZH2 isoform b

    See identical proteins and their annotated locations for NP_694543.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon and an in-frame segment in the coding region, as compared to variant 1. The resulting isoform (b) lacks two internal segments, as compared to isoform a.
    Source sequence(s)
    AK314291, BC010858, BU953788, CN283479
    Consensus CDS
    CCDS5892.1
    UniProtKB/TrEMBL
    Q75MP9, S4S3R8
    Related
    ENSP00000223193.2, ENST00000350995.6
    Conserved Domains (4) summary
    cd19218
    Location:570 → 689
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:39 → 68
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:119 → 210
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:520 → 551
    preSET_CXC; CXC domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    148807383..148884291 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420002.1 → XP_047275958.1  histone-lysine N-methyltransferase EZH2 isoform X22

  2. XM_017011820.3 → XP_016867309.1  histone-lysine N-methyltransferase EZH2 isoform X20

    UniProtKB/TrEMBL
    Q75MQ0
    Conserved Domains (4) summary
    cd19218
    Location:566 → 685
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:39 → 68
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:110 → 201
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:516 → 547
    preSET_CXC; CXC domain

  3. XM_011515887.4 → XP_011514189.1  histone-lysine N-methyltransferase EZH2 isoform X7

    See identical proteins and their annotated locations for XP_011514189.1

    UniProtKB/TrEMBL
    Q75MQ0
    Conserved Domains (4) summary
    cd19218
    Location:605 → 724
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:39 → 68
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:149 → 240
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:555 → 586
    preSET_CXC; CXC domain

  4. XM_047420004.1 → XP_047275960.1  histone-lysine N-methyltransferase EZH2 isoform X24

    UniProtKB/TrEMBL
    F2YMM1

  5. XM_011515894.3 → XP_011514196.1  histone-lysine N-methyltransferase EZH2 isoform X14

    See identical proteins and their annotated locations for XP_011514196.1

    UniProtKB/TrEMBL
    Q75MQ0
    Conserved Domains (4) summary
    cd19218
    Location:575 → 694
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:39 → 68
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:119 → 210
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:525 → 556
    preSET_CXC; CXC domain

  6. XM_047420001.1 → XP_047275957.1  histone-lysine N-methyltransferase EZH2 isoform X19

  7. XM_047419999.1 → XP_047275955.1  histone-lysine N-methyltransferase EZH2 isoform X17

  8. XM_047419990.1 → XP_047275946.1  histone-lysine N-methyltransferase EZH2 isoform X2

  9. XM_047419997.1 → XP_047275953.1  histone-lysine N-methyltransferase EZH2 isoform X9

  10. XM_047419992.1 → XP_047275948.1  histone-lysine N-methyltransferase EZH2 isoform X4

    UniProtKB/Swiss-Prot
    B2RAQ1, B3KS30, B7Z1D6, B7Z7L6, Q15755, Q15910, Q75MG3, Q92857, Q96FI6

  11. XM_047419993.1 → XP_047275949.1  histone-lysine N-methyltransferase EZH2 isoform X5

  12. XM_047419998.1 → XP_047275954.1  histone-lysine N-methyltransferase EZH2 isoform X13

  13. XM_011515883.3 → XP_011514185.1  histone-lysine N-methyltransferase EZH2 isoform X1

    See identical proteins and their annotated locations for XP_011514185.1

    UniProtKB/TrEMBL
    Q75MQ0
    Conserved Domains (2) summary
    smart00317
    Location:625 → 746
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam11616
    Location:47 → 75
    EZH2_WD-Binding; WD repeat binding protein EZH2

  14. XM_047419994.1 → XP_047275950.1  histone-lysine N-methyltransferase EZH2 isoform X5

  15. XM_005249962.5 → XP_005250019.1  histone-lysine N-methyltransferase EZH2 isoform X2

    See identical proteins and their annotated locations for XP_005250019.1

    UniProtKB/TrEMBL
    Q75MP9
    Conserved Domains (4) summary
    cd19218
    Location:617 → 736
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:47 → 76
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:166 → 257
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:567 → 598
    preSET_CXC; CXC domain

  16. XM_047419989.1 → XP_047275945.1  histone-lysine N-methyltransferase EZH2 isoform X1

  17. XM_047419991.1 → XP_047275947.1  histone-lysine N-methyltransferase EZH2 isoform X30

    UniProtKB/TrEMBL
    A0A090N8E9

  18. XM_047420000.1 → XP_047275956.1  histone-lysine N-methyltransferase EZH2 isoform X18

  19. XM_011515895.3 → XP_011514197.1  histone-lysine N-methyltransferase EZH2 isoform X16

    UniProtKB/TrEMBL
    Q75MQ0
    Conserved Domains (2) summary
    smart00317
    Location:577 → 698
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam11616
    Location:47 → 75
    EZH2_WD-Binding; WD repeat binding protein EZH2

  20. XM_005249964.5 → XP_005250021.1  histone-lysine N-methyltransferase EZH2 isoform X21

    See identical proteins and their annotated locations for XP_005250021.1

    UniProtKB/TrEMBL
    Q75MP9
    Conserved Domains (2) summary
    smart00317
    Location:569 → 690
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam11616
    Location:47 → 75
    EZH2_WD-Binding; WD repeat binding protein EZH2

  21. XM_005249963.5 → XP_005250020.1  histone-lysine N-methyltransferase EZH2 isoform X5

    See identical proteins and their annotated locations for XP_005250020.1

    UniProtKB/TrEMBL
    Q75MP9
    Conserved Domains (4) summary
    cd19218
    Location:608 → 727
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:47 → 76
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:157 → 248
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:558 → 589
    preSET_CXC; CXC domain

  22. XM_011515885.3 → XP_011514187.1  histone-lysine N-methyltransferase EZH2 isoform X3

    UniProtKB/TrEMBL
    Q75MQ0
    Conserved Domains (4) summary
    cd19218
    Location:613 → 732
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:47 → 76
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:157 → 248
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:563 → 594
    preSET_CXC; CXC domain

  23. XM_011515896.3 → XP_011514198.1  histone-lysine N-methyltransferase EZH2 isoform X23

    See identical proteins and their annotated locations for XP_011514198.1

    UniProtKB/TrEMBL
    Q75MP9
    Conserved Domains (2) summary
    smart00317
    Location:539 → 660
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam11616
    Location:47 → 75
    EZH2_WD-Binding; WD repeat binding protein EZH2

  24. XM_011515893.3 → XP_011514195.1  histone-lysine N-methyltransferase EZH2 isoform X13

    See identical proteins and their annotated locations for XP_011514195.1

    UniProtKB/TrEMBL
    Q75MP9
    Conserved Domains (2) summary
    smart00317
    Location:581 → 702
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam11616
    Location:47 → 75
    EZH2_WD-Binding; WD repeat binding protein EZH2

  25. XM_011515890.3 → XP_011514192.1  histone-lysine N-methyltransferase EZH2 isoform X11

    UniProtKB/TrEMBL
    Q75MQ0
    Conserved Domains (2) summary
    smart00317
    Location:586 → 707
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam11616
    Location:47 → 75
    EZH2_WD-Binding; WD repeat binding protein EZH2

  26. XM_017011819.2 → XP_016867308.1  histone-lysine N-methyltransferase EZH2 isoform X15

    UniProtKB/TrEMBL
    Q75MP9
    Conserved Domains (2) summary
    smart00317
    Location:578 → 699
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam11616
    Location:47 → 75
    EZH2_WD-Binding; WD repeat binding protein EZH2

  27. XM_011515892.3 → XP_011514194.1  histone-lysine N-methyltransferase EZH2 isoform X12

    See identical proteins and their annotated locations for XP_011514194.1

    UniProtKB/TrEMBL
    Q75MQ0
    Conserved Domains (2) summary
    smart00317
    Location:583 → 704
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam11616
    Location:47 → 75
    EZH2_WD-Binding; WD repeat binding protein EZH2

  28. XM_017011817.3 → XP_016867306.1  histone-lysine N-methyltransferase EZH2 isoform X1

    UniProtKB/TrEMBL
    Q75MQ0
    Conserved Domains (2) summary
    smart00317
    Location:625 → 746
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam11616
    Location:47 → 75
    EZH2_WD-Binding; WD repeat binding protein EZH2

  29. XM_011515889.3 → XP_011514191.1  histone-lysine N-methyltransferase EZH2 isoform X10

    UniProtKB/TrEMBL
    Q75MQ0
    Conserved Domains (3) summary
    cd19218
    Location:592 → 711
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam18118
    Location:136 → 227
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:542 → 573
    preSET_CXC; CXC domain

  30. XM_047419996.1 → XP_047275952.1  histone-lysine N-methyltransferase EZH2 isoform X8

  31. XM_047419995.1 → XP_047275951.1  histone-lysine N-methyltransferase EZH2 isoform X6

  32. XM_047420005.1 → XP_047275961.1  histone-lysine N-methyltransferase EZH2 isoform X25

  33. XM_047420006.1 → XP_047275962.1  histone-lysine N-methyltransferase EZH2 isoform X25

  34. XM_011515901.4 → XP_011514203.1  histone-lysine N-methyltransferase EZH2 isoform X28

    See identical proteins and their annotated locations for XP_011514203.1

    UniProtKB/TrEMBL
    B7Z8K5
    Conserved Domains (1) summary
    pfam11616
    Location:47 → 75
    EZH2_WD-Binding; WD repeat binding protein EZH2

  35. XM_047420008.1 → XP_047275964.1  histone-lysine N-methyltransferase EZH2 isoform X28

  36. XM_047420007.1 → XP_047275963.1  histone-lysine N-methyltransferase EZH2 isoform X27

  37. XM_011515899.4 → XP_011514201.1  histone-lysine N-methyltransferase EZH2 isoform X26

    Conserved Domains (1) summary
    pfam11616
    Location:47 → 75
    EZH2_WD-Binding; WD repeat binding protein EZH2

  38. XM_047420009.1 → XP_047275965.1  histone-lysine N-methyltransferase EZH2 isoform X29

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    149989157..150066070 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054357507.1 → XP_054213482.1  histone-lysine N-methyltransferase EZH2 isoform X22

  2. XM_054357505.1 → XP_054213480.1  histone-lysine N-methyltransferase EZH2 isoform X20

  3. XM_054357491.1 → XP_054213466.1  histone-lysine N-methyltransferase EZH2 isoform X7

  4. XM_054357509.1 → XP_054213484.1  histone-lysine N-methyltransferase EZH2 isoform X24

    UniProtKB/TrEMBL
    F2YMM1

  5. XM_054357499.1 → XP_054213474.1  histone-lysine N-methyltransferase EZH2 isoform X14

  6. XM_054357504.1 → XP_054213479.1  histone-lysine N-methyltransferase EZH2 isoform X19

  7. XM_054357502.1 → XP_054213477.1  histone-lysine N-methyltransferase EZH2 isoform X17

  8. XM_054357484.1 → XP_054213459.1  histone-lysine N-methyltransferase EZH2 isoform X2

  9. XM_054357493.1 → XP_054213468.1  histone-lysine N-methyltransferase EZH2 isoform X9

  10. XM_054357486.1 → XP_054213461.1  histone-lysine N-methyltransferase EZH2 isoform X4

    UniProtKB/Swiss-Prot
    B2RAQ1, B3KS30, B7Z1D6, B7Z7L6, Q15755, Q15910, Q75MG3, Q92857, Q96FI6

  11. XM_054357488.1 → XP_054213463.1  histone-lysine N-methyltransferase EZH2 isoform X5

  12. XM_054357498.1 → XP_054213473.1  histone-lysine N-methyltransferase EZH2 isoform X13

  13. XM_054357482.1 → XP_054213457.1  histone-lysine N-methyltransferase EZH2 isoform X1

  14. XM_054357489.1 → XP_054213464.1  histone-lysine N-methyltransferase EZH2 isoform X5

  15. XM_054357483.1 → XP_054213458.1  histone-lysine N-methyltransferase EZH2 isoform X2

  16. XM_054357481.1 → XP_054213456.1  histone-lysine N-methyltransferase EZH2 isoform X1

  17. XM_054357496.1 → XP_054213471.1  histone-lysine N-methyltransferase EZH2 isoform X12

  18. XM_054357501.1 → XP_054213476.1  histone-lysine N-methyltransferase EZH2 isoform X16

  19. XM_054357506.1 → XP_054213481.1  histone-lysine N-methyltransferase EZH2 isoform X21

  20. XM_054357485.1 → XP_054213460.1  histone-lysine N-methyltransferase EZH2 isoform X3

  21. XM_054357508.1 → XP_054213483.1  histone-lysine N-methyltransferase EZH2 isoform X23

  22. XM_054357495.1 → XP_054213470.1  histone-lysine N-methyltransferase EZH2 isoform X11

  23. XM_054357500.1 → XP_054213475.1  histone-lysine N-methyltransferase EZH2 isoform X15

  24. XM_054357480.1 → XP_054213455.1  histone-lysine N-methyltransferase EZH2 isoform X1

  25. XM_054357503.1 → XP_054213478.1  histone-lysine N-methyltransferase EZH2 isoform X18

  26. XM_054357487.1 → XP_054213462.1  histone-lysine N-methyltransferase EZH2 isoform X5

  27. XM_054357497.1 → XP_054213472.1  histone-lysine N-methyltransferase EZH2 isoform X13

  28. XM_054357494.1 → XP_054213469.1  histone-lysine N-methyltransferase EZH2 isoform X10

  29. XM_054357492.1 → XP_054213467.1  histone-lysine N-methyltransferase EZH2 isoform X8

  30. XM_054357490.1 → XP_054213465.1  histone-lysine N-methyltransferase EZH2 isoform X6

  31. XM_054357510.1 → XP_054213485.1  histone-lysine N-methyltransferase EZH2 isoform X25

  32. XM_054357511.1 → XP_054213486.1  histone-lysine N-methyltransferase EZH2 isoform X25

  33. XM_054357515.1 → XP_054213490.1  histone-lysine N-methyltransferase EZH2 isoform X28

  34. XM_054357514.1 → XP_054213489.1  histone-lysine N-methyltransferase EZH2 isoform X28

  35. XM_054357513.1 → XP_054213488.1  histone-lysine N-methyltransferase EZH2 isoform X27

  36. XM_054357512.1 → XP_054213487.1  histone-lysine N-methyltransferase EZH2 isoform X26

  37. XM_054357516.1 → XP_054213491.1  histone-lysine N-methyltransferase EZH2 isoform X29

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15910.2 GenPept UniProtKB/Swiss-Prot:Q15910

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