Slc36a1 solute carrier family 36 (proton/amino acid symporter), member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc36a1provided by MGI
Official Full Name: solute carrier family 36 (proton/amino acid symporter), member 1provided by MGI
Primary source: MGI:MGI:2445299
See related: Ensembl:ENSMUSG00000020261 AllianceGenome:MGI:2445299
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pat1; 5830411H19Rik
Summary: Enables amino acid transmembrane transporter activity. Acts upstream of or within neutral amino acid transport and proton transmembrane transport. Predicted to be located in endoplasmic reticulum; lysosome; and plasma membrane. Is expressed in alimentary system; nervous system; rib; and urethra. Orthologous to human SLC36A1 (solute carrier family 36 member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in duodenum adult (RPKM 30.1), colon adult (RPKM 23.2) and 28 other tissues See more
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Genomic context

Location:: 11 B1.3; 11 32.33 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (55095148..55127156)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (55204322..55236330)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Insights into the Interaction of Lysosomal Amino Acid Transporters SLC38A9 and SLC36A1 Involved in mTORC1 Signaling in C2C12 Cells.
Title: Insights into the Interaction of Lysosomal Amino Acid Transporters SLC38A9 and SLC36A1 Involved in mTORC1 Signaling in C2C12 Cells.
Data suggest that a high-fat diet induces expression of two amino acid transporters (Slc36a1, Slc6a20a) in intestinal mucosa pointing to a specific and adaptive absorption of some amino acids in high-fat diet-induced obesity and glucose intolerance.
Title: Disturbed intestinal nitrogen homeostasis in a mouse model of high-fat diet-induced obesity and glucose intolerance.
The essential role of chloride and fructose absorbing Slc36a1 is reported.
Title: Fructose-induced hypertension: essential role of chloride and fructose absorbing transporters PAT1 and Glut5.
detailed analysis of the transport mode of the murine PAT1 in oocytes; PAT1 is an electrogenic H+-coupled amino acid symporter with the capability for bidirectional amino acid transport
Title: Kinetics of bidirectional H+ and substrate transport by the proton-dependent amino acid symporter PAT1.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

General gene information

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Markers

Slc36a1 (e-PCR), detects polymorphism
- UniSTS:547336

AI839897 (e-PCR)
- UniSTS:165753

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-alanine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-alanine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-proline transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-proline transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
NOT enables L-tyrosine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables alanine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables amino acid:proton symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables amino acid:proton symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables amino acid:proton symporter activity	ISO Inferred from Sequence Orthology more info
enables glycine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables neutral L-amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables proline:proton symporter activity	ISO Inferred from Sequence Orthology more info
enables proton transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables symporter activity	IEA Inferred from Electronic Annotation more info
enables taurine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in L-alanine transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within L-alanine transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within L-alpha-amino acid transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in alanine transport	ISO Inferred from Sequence Orthology more info
involved_in amino acid import across plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within amino acid transport	IEA Inferred from Electronic Annotation more info
involved_in glycine transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glycine transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neutral amino acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in neutral amino acid transport	ISO Inferred from Sequence Orthology more info
involved_in proline transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proline transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within proline transport	IDA Inferred from Direct Assay more info	PubMed
involved_in proton transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proton transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in proton transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in taurine transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISO Inferred from Sequence Orthology more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in vacuolar membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: proton-coupled amino acid transporter 1

Names: proton/amino acid transporter 1; solute carrier family 36 member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.