Tshr thyroid stimulating hormone receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tshrprovided by MGI
Official Full Name: thyroid stimulating hormone receptorprovided by MGI
Primary source: MGI:MGI:98849
See related: Ensembl:ENSMUSG00000020963 AllianceGenome:MGI:98849
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: hyt; pet; hypothroid
Summary: Enables thyroid-stimulating hormone receptor activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including adult locomotory behavior; dopaminergic neuron differentiation; and inner ear development. Located in plasma membrane. Is expressed in bladder; renal vasculature; thyroid gland; and thyroid gland lobe. Used to study congenital hypothyroidism. Human ortholog(s) of this gene implicated in Graves' disease; cardiomyopathy; congenital nongoitrous hypothyroidism 1; and mitral valve prolapse. Orthologous to human TSHR (thyroid stimulating hormone receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in subcutaneous fat pad adult (RPKM 19.7), genital fat pad adult (RPKM 11.8) and 3 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 12 D3; 12 44.51 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (91367767..91507283)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (91400993..91540509)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mechanisms of thyrotropin receptor-mediated phenotype variability deciphered by gene mutations and M453T-knockin model.
Title: Mechanisms of thyrotropin receptor-mediated phenotype variability deciphered by gene mutations and M453T-knockin model.
TSH Pulses Finely Tune Thyroid Hormone Release and TSH Receptor Transduction.
Title: TSH Pulses Finely Tune Thyroid Hormone Release and TSH Receptor Transduction.
Activation of mitogen-activated protein kinase signaling and development of papillary thyroid carcinoma in thyroid-stimulating hormone receptor D633H knockin mice.
Title: Activation of mitogen-activated protein kinase signaling and development of papillary thyroid carcinoma in thyroid-stimulating hormone receptor D633H knockin mice.
Presence of TSHR in NK Cells and Action of TSH on NK Cells.
Title: Presence of TSHR in NK Cells and Action of TSH on NK Cells.
Long Term Rescue of the TSH Receptor Knock-Out Mouse - Thyroid Stem Cell Transplantation Restores Thyroid Function.
Title: Long Term Rescue of the TSH Receptor Knock-Out Mouse - Thyroid Stem Cell Transplantation Restores Thyroid Function.
Adipose-specific inactivation of thyroid stimulating hormone receptors in mice modifies body weight, temperature and gene expression in adipocytes.
Title: Adipose-specific inactivation of thyroid stimulating hormone receptors in mice modifies body weight, temperature and gene expression in adipocytes.
The Amino Acid Transporter Mct10/Tat1 Is Important to Maintain the TSH Receptor at Its Canonical Basolateral Localization and Assures Regular Turnover of Thyroid Follicle Cells in Male Mice.
Title: The Amino Acid Transporter Mct10/Tat1 Is Important to Maintain the TSH Receptor at Its Canonical Basolateral Localization and Assures Regular Turnover of Thyroid Follicle Cells in Male Mice.
A Mouse Thyrotropin Receptor A-Subunit Transgene Expressed in Thyroiditis-Prone Mice May Provide Insight into Why Graves' Disease Only Occurs in Humans.
Title: A Mouse Thyrotropin Receptor A-Subunit Transgene Expressed in Thyroiditis-Prone Mice May Provide Insight into Why Graves' Disease Only Occurs in Humans.
Expression of TSHR and of CART is suppressed in response to lipopolysaccharides within the arcuate nucleus in the hypothalamus of the mouse. The present findings highlight hypothalamic TSH receptor mechanisms and CART as putative adaptive neuroendocrine components in the response to acute inflammation. Findings suggest that central and peripheral CART is affected by acute inflammation.
Title: LPS immune challenge reduces arcuate nucleus TSHR and CART mRNA and elevates plasma CART peptides.
analysis of TSHR expression in mouse pancreatic beta cells
Title: The Adverse Effects of Thyrotropin Absence on Pancreatic β Cell Function in Mice.

Submit: New GeneRIF Correction See all GeneRIFs (42)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (3)
Targeted (3) 1 citation
Chemically induced (ENU) (1)
Endonuclease-mediated (3)

General gene information

Go to the top of the page Help

Markers

PMC137792P2 (e-PCR)
- UniSTS:270856

RH144511 (e-PCR)
- UniSTS:233756

Tshr (e-PCR), detects polymorphism
- UniSTS:516183

AI481368 (e-PCR)
- UniSTS:185944

U02602 (e-PCR)
- UniSTS:125641

D12Mit118 (e-PCR), detects polymorphism
- UniSTS:126669

D12Mit119 (e-PCR), detects polymorphism
- UniSTS:126670

U02601 (e-PCR)
- UniSTS:180441

U02602 (e-PCR)
- UniSTS:160242

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables protein-hormone receptor activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor activity	ISO Inferred from Sequence Orthology more info
enables thyroid-stimulating hormone receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables thyroid-stimulating hormone receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables thyroid-stimulating hormone receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in activation of adenylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adult locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glycoprotein	ISO Inferred from Sequence Orthology more info
involved_in cellular response to thyrotropin-releasing hormone	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cochlea morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dopaminergic neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hormone-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inner ear receptor cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner ear receptor cell stereocilium organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in thyroid-stimulating hormone signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: thyrotropin receptor

Names: TSH-R

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113404.1 → NP_001106875.1 thyrotropin receptor isoform 2 precursor

See identical proteins and their annotated locations for NP_001106875.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate exon in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 2) that has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AK041086, BB645263

Consensus CDS

CCDS49135.1

UniProtKB/TrEMBL

Q78U67

Related

ENSMUSP00000021343.7, ENSMUST00000021343.8

Conserved Domains (2) summary

sd00033
Location:55 → 77

LRR_RI; leucine-rich repeat [structural motif]

pfam13306
Location:65 → 221

LRR_5; Leucine rich repeats (6 copies)
NM_011648.5 → NP_035778.3 thyrotropin receptor isoform 1 precursor

See identical proteins and their annotated locations for NP_035778.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

BB645263, BC086691

Consensus CDS

CCDS26088.1

UniProtKB/Swiss-Prot

P47750, Q562E4, Q9D697

Related

ENSMUSP00000021346.8, ENSMUST00000021346.14

Conserved Domains (4) summary

pfam00001
Location:437 → 678

7tm_1; 7 transmembrane receptor (rhodopsin family)

pfam13855
Location:76 → 138

LRR_8; Leucine rich repeat

cl21587
Location:417 → 527

7tm_2; 7 transmembrane receptor (Secretin family)

sd00033
Location:54 → 77

LRR_RI; leucine-rich repeat [structural motif]