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SLC16A9 solute carrier family 16 member 9 [ Homo sapiens (human) ]

Gene ID: 220963, updated on 5-Mar-2024

Summary

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Official Symbol
SLC16A9provided by HGNC
Official Full Name
solute carrier family 16 member 9provided by HGNC
Primary source
HGNC:HGNC:23520
See related
Ensembl:ENSG00000165449 MIM:614242; AllianceGenome:HGNC:23520
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCT9; C10orf36
Summary
Predicted to enable monocarboxylic acid transmembrane transporter activity. Involved in urate metabolic process. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in adrenal (RPKM 82.1), kidney (RPKM 62.2) and 9 other tissues See more
Orthologs
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Genomic context

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See SLC16A9 in Genome Data Viewer
Location:
10q21.2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (59650764..59710079, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (60504785..60564169, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (61410522..61469837, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378318 Neighboring gene Sharpr-MPRA regulatory region 11473 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3386 Neighboring gene uncharacterized LOC105378319 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3387 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2382 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2383 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2384 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:61521925-61522472 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:61529872-61530061 Neighboring gene myoregulin Neighboring gene NANOG hESC enhancer GRCh37_chr10:61549690-61550191 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:61562933-61563434 Neighboring gene coiled-coil domain containing 6 Neighboring gene Sharpr-MPRA regulatory region 6982 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:61607379-61608319 Neighboring gene Sharpr-MPRA regulatory region 3861 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3388 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3389 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3390 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2385 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3391 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2386 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2387

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Monocarboxylate transporter 9 (MCT9) is down-regulated in renal cell carcinoma. Yoo A, et al. Genes Genomics, 2021 Apr. PMID 33555501
  2. HBsAg loss in patients treated with peginterferon alfa-2a and adefovir is associated with SLC16A9 gene variation and lower plasma carnitine levels. Jansen L, et al. J Hepatol, 2014 Oct. PMID 24824278
  3. Common missense variant of monocarboxylate transporter 9 (MCT9/SLC16A9) gene is associated with renal overload gout, but not with all gout susceptibility. Nakayama A, et al. Hum Cell, 2013 Dec. PMID 23990105, Free PMC Article
  4. The tissue expression of MCT3, MCT8, and MCT9 genes in women with breast cancer. Sohrabi E, et al. Genes Genomics, 2021 Sep. PMID 34097251
  5. SLC1A1, SLC16A9, and CNTN3 Are Potential Biomarkers for the Occurrence of Colorectal Cancer. Zhou J, et al. Biomed Res Int, 2020. PMID 32566650, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Molecular characteristic analysis of single-nucleotide polymorphisms in SLC16A9/hMCT9.
    Title: Molecular characteristic analysis of single-nucleotide polymorphisms in SLC16A9/hMCT9.
  2. The tissue expression of MCT3, MCT8, and MCT9 genes in women with breast cancer.
    Title: The tissue expression of MCT3, MCT8, and MCT9 genes in women with breast cancer.
  3. Monocarboxylate transporter 9 (MCT9) is down-regulated in renal cell carcinoma.
    Title: Monocarboxylate transporter 9 (MCT9) is down-regulated in renal cell carcinoma.
  4. SLC1A1, SLC16A9, and CNTN3 Are Potential Biomarkers for the Occurrence of Colorectal Cancer.
    Title: SLC1A1, SLC16A9, and CNTN3 Are Potential Biomarkers for the Occurrence of Colorectal Cancer.
  5. Molecular characterization of the orphan transporter SLC16A9, an extracellular pH- and Na(+)-sensitive creatine transporter.
    Title: Molecular characterization of the orphan transporter SLC16A9, an extracellular pH- and Na(+)-sensitive creatine transporter.
  6. Strong association of SLC16A9 gene variation with HBsAg loss was identified in Chronic Hepatitis B patients treated with peginterferon and adefovir.
    Title: HBsAg loss in patients treated with peginterferon alfa-2a and adefovir is associated with SLC16A9 gene variation and lower plasma carnitine levels.
  7. it has a possible physiological role in urate excretion from human intestinal epithelial cells.
    Title: Common missense variant of monocarboxylate transporter 9 (MCT9/SLC16A9) gene is associated with renal overload gout, but not with all gout susceptibility.
  8. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
    Title: Predictive value of 8 genetic loci for serum uric acid concentration.
  9. Observational study of gene-disease association. (HuGE Navigator)
    Title: Common variants in SLC17A3 gene affect intra-personal variation in serum uric acid levels in longitudinal time series.
  10. Meta-analysis of gene-disease association. (HuGE Navigator)
    Title: Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
An atlas of genetic influences on human blood metabolites.
EBI GWAS Catalog
Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9.
EBI GWAS Catalog
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
EBI GWAS Catalog
Human metabolic individuality in biomedical and pharmaceutical research.
EBI GWAS Catalog
Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ43803

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carnitine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables creatine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monocarboxylic acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carnitine transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in creatine transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in monocarboxylic acid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in urate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
monocarboxylate transporter 9
Names
MCT 9
monocarboxylic acid transporter 9
solute carrier family 16 (monocarboxylic acid transporters), member 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001323977.1 → NP_001310906.1  monocarboxylate transporter 9 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variants 4, 5, and 6, encodes isoform b.
    Source sequence(s)
    AC026391, DA759951

  2. NM_001323978.2 → NP_001310907.1  monocarboxylate transporter 9 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variants 3, 5, and 6, encodes isoform b.
    Source sequence(s)
    AC022027, AC026391

  3. NM_001323979.2 → NP_001310908.1  monocarboxylate transporter 9 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 3, 4, and 6, encodes isoform b.
    Source sequence(s)
    AC022027, AC026391

  4. NM_001323980.2 → NP_001310909.1  monocarboxylate transporter 9 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 3, 4, and 5, encodes isoform b.
    Source sequence(s)
    AC022027, AC026391

  5. NM_001323981.2 → NP_001310910.1  monocarboxylate transporter 9 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), as well as variant 1, encodes isoform a.
    Source sequence(s)
    AC022027, AC026391
    Consensus CDS
    CCDS7256.1
    UniProtKB/Swiss-Prot
    Q6ZMI2, Q7RTY1, Q9UFH8
    Conserved Domains (1) summary
    cl26868
    Location:7 → 481
    2A0111; oxalate/formate antiporter family transporter

  6. NM_194298.3 → NP_919274.1  monocarboxylate transporter 9 isoform a

    See identical proteins and their annotated locations for NP_919274.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1), as well as variant 2, encodes isoform a.
    Source sequence(s)
    AK125791, BC126238, BX092606, CX784319, DA229807
    Consensus CDS
    CCDS7256.1
    UniProtKB/Swiss-Prot
    Q6ZMI2, Q7RTY1, Q9UFH8
    Related
    ENSP00000378757.3, ENST00000395348.8
    Conserved Domains (1) summary
    cl26868
    Location:7 → 481
    2A0111; oxalate/formate antiporter family transporter

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    59650764..59710079 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017015883.2 → XP_016871372.1  monocarboxylate transporter 9 isoform X1

  2. XM_017015884.3 → XP_016871373.1  monocarboxylate transporter 9 isoform X2

    UniProtKB/Swiss-Prot
    Q6ZMI2, Q7RTY1, Q9UFH8
    Conserved Domains (1) summary
    cl26868
    Location:7 → 481
    2A0111; oxalate/formate antiporter family transporter

  3. XM_047424753.1 → XP_047280709.1  monocarboxylate transporter 9 isoform X1

  4. XM_047424754.1 → XP_047280710.1  monocarboxylate transporter 9 isoform X1

  5. XM_047424757.1 → XP_047280713.1  monocarboxylate transporter 9 isoform X2

    UniProtKB/Swiss-Prot
    Q6ZMI2, Q7RTY1, Q9UFH8

  6. XM_047424755.1 → XP_047280711.1  monocarboxylate transporter 9 isoform X1

  7. XM_024447878.2 → XP_024303646.1  monocarboxylate transporter 9 isoform X2

    UniProtKB/Swiss-Prot
    Q6ZMI2, Q7RTY1, Q9UFH8
    Conserved Domains (1) summary
    cl26868
    Location:7 → 481
    2A0111; oxalate/formate antiporter family transporter

  8. XM_047424756.1 → XP_047280712.1  monocarboxylate transporter 9 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    60504785..60564169 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054365082.1 → XP_054221057.1  monocarboxylate transporter 9 isoform X2

  2. XM_054365080.1 → XP_054221055.1  monocarboxylate transporter 9 isoform X1

  3. XM_054365075.1 → XP_054221050.1  monocarboxylate transporter 9 isoform X1

  4. XM_054365081.1 → XP_054221056.1  monocarboxylate transporter 9 isoform X2

  5. XM_054365076.1 → XP_054221051.1  monocarboxylate transporter 9 isoform X1

  6. XM_054365077.1 → XP_054221052.1  monocarboxylate transporter 9 isoform X1

  7. XM_054365083.1 → XP_054221058.1  monocarboxylate transporter 9 isoform X2

  8. XM_054365078.1 → XP_054221053.1  monocarboxylate transporter 9 isoform X1

  9. XM_054365084.1 → XP_054221059.1  monocarboxylate transporter 9 isoform X2

  10. XM_054365079.1 → XP_054221054.1  monocarboxylate transporter 9 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7RTY1.1 GenPept UniProtKB/Swiss-Prot:Q7RTY1

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