Ubc ubiquitin C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ubcprovided by MGI
Official Full Name: ubiquitin Cprovided by MGI
Primary source: MGI:MGI:98889
See related: Ensembl:ENSMUSG00000008348 AllianceGenome:MGI:98889
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ubb; Uba52; Rps27a; TI-225; 2700054O04Rik
Summary: Predicted to enable protease binding activity; protein tag; and ubiquitin protein ligase binding activity. Predicted to be involved in modification-dependent protein catabolic process and protein ubiquitination. Located in myelin sheath. Is expressed in inner ear; oocyte; telencephalon; and trunk unsegmented mesenchyme. Orthologous to human UBC (ubiquitin C). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in subcutaneous fat pad adult (RPKM 4219.9), ovary adult (RPKM 3990.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G1.1; 5 64.18 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (125463029..125467081, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (125385965..125390017, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ubiquitin links smoothened to intraflagellar transport to regulate Hedgehog signaling.
Title: Ubiquitin links smoothened to intraflagellar transport to regulate Hedgehog signaling.
Ubc-/- mouse embryonic fibroblasts (MEFs) exhibited reduced viability under As(III) exposure, although the Nrf2-Keap1 pathway was activated as a cytoprotective response.
Title: Disruption of polyubiquitin gene Ubc leads to attenuated resistance against arsenite-induced toxicity in mouse embryonic fibroblasts.
phosphorylation of Parkin at Ser-65 following dissipation of DeltaPsim triggers ubiquitin-ester transfer by the RING2 domain of Parkin to Cys-431.
Title: Parkin-catalyzed ubiquitin-ester transfer is triggered by PINK1-dependent phosphorylation.
Defective proliferation of fetal liver cells contributes to severe reduction of fetal liver size and potentially mid-gestation lethality of Ubc-deficient embryos
Title: Disruption of polyubiquitin gene Ubc leads to defective proliferation of hepatocytes and bipotent fetal liver epithelial progenitor cells.
Data indicate that Ubc and Ywhaz were best correlated for B cells and lymphocytes, whereas Ubc and Gapdh were the best combination for non-B cells, and Actb and Hprt1 were the least stably expressed genes for B cells and non-B cell.
Title: Evaluation of reference genes for quantitative PCR analysis of mouse lymphocytes.
the lethality of Ubc(-/-) embryos is not the result of intrinsic HSC failure
Title: Perturbation of the hematopoietic system during embryonic liver development due to disruption of polyubiquitin gene Ubc in mice.
reduction of Ubc expression in R6/2; Ubc+/- mice largely prevented this increase in uH2A levels
Title: The polyubiquitin Ubc gene modulates histone H2A monoubiquitylation in the R6/2 mouse model of Huntington's disease.
The mouse polyubiquitin gene UbC is essential for fetal liver development, cell-cycle progression and stress tolerance.
Title: The mouse polyubiquitin gene UbC is essential for fetal liver development, cell-cycle progression and stress tolerance.
regulation of ubiquitin C expression contributes to attenuation of skin carcinogenesis
Title: Peroxisome proliferator-activated receptor beta (delta)-dependent regulation of ubiquitin C expression contributes to attenuation of skin carcinogenesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI194771 (e-PCR)
- UniSTS:179273

Ubc (e-PCR), detects polymorphism
- UniSTS:532466

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tag activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in modification-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in myelin sheath	HDA more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: polyubiquitin-C

Names: polyubiquitin C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.